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[1]李耿,汪天呈,姚海燕,等.岗梅根水提物在小鼠体内抗H9N2亚型禽流感病毒实验研究[J].环球中医药,2012,5(02):84-0.
　LI Geng,WANG Tian cheng,YAO Hai yan,et al.Experimental　study of antiinfluenza virus H9N2 effects of the water extract of Radix et Caulis Ilicis Asprellae in vivo[J].,2012,5(02):84-0.
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岗梅根水提物在小鼠体内抗H9N2亚型禽流感病毒实验研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第5卷
期数:
2012年02期
页码:
84-0
栏目:
中药抗菌抗病毒研究
出版日期:
2012-02-06

文章信息/Info

Title:
Experimental　study of antiinfluenza virus H9N2 effects of the water extract of Radix et Caulis Ilicis Asprellae in vivo
作者:
李耿; 汪天呈; 姚海燕; 陈建新; 吴依娜; 林吉; 赖小平;
Author(s):
LI Geng;  WANG Tiancheng;  YAO Haiyan ;  et al.
Herbal Medicine Research College in Guangzhou University of TCM, Guangzhou 510405, China
关键词:
岗梅根水提物;  小鼠;  H9N2亚型禽流感病毒;  体内;  肺指数;  死亡保护率
Keywords:
The water extract of Radix et Caulis Ilicis Asprellae; Mice; H9N2 subtype avian influenza virus; In vivo; Lung index; Deathprotection rate
分类号:
R285.5
DOI:
-
文献标志码:
A
摘要:
目的观察岗梅根水提物对滴鼻感染H9N2亚型禽流感病毒小鼠的保护作用。方法以磷酸奥司他韦为阳性药,通过H9N2亚型禽流感病毒滴鼻感染小鼠,分别建立小鼠病毒性肺炎动物模型和病毒感染致小鼠死亡的动物模型,观察小鼠肺部病变和死亡情况,以肺指数及小鼠死亡率作为观测指标,评价岗梅根水提物对感染H9N2亚型禽流感病毒小鼠的保护效果。结果岗梅根水提物中、低剂量组可显著降低禽流感病毒感染小鼠的肺指数(P<0.01); 降低禽流感病毒感染小鼠死亡率,延长其存活时间(P<0.01)。结论岗梅根水提物对滴鼻感染H9N2亚型禽流感病毒小鼠具有良好的保护作用。
Abstract:
ObjectiveTo study the inhibitory effects of the water extract of Radix et Caulis Ilicis Asprellae on aiv influenza virus H9N2 in vivo. MethodsThe model mice were infected by nasal dripping of H9N2 subtype avian influenza virus. Oseltamivir was selcted as the positive control.The inhibitory effects of Radix et Caulis Ilicis Asprellae on influenza viral pneumonia were observed. The lung index and motality rate were selected as indicators of protective effect. ResultsCompared with the viral control group, lowdose and middledose water extract of Radix et Caulis Ilicis Asprellae can obviously ease lung inflammation of mice infected by aiv influenza virus H9N2, reduce the lung index, decrease the motality rate of the mice infected by H9N2 subtype avian influenza virus, and extend the survival time. Conclusion Radix et Caulis Ilicis Asprellae has strong inhibitory effects on aiv influenza virus H9N2

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（U0732004）
作者单位：510405 广州中医药大学中药学院
作者简介：李耿（1983- ），博士，讲师。研究方向：教学及抗病毒研究。Email：lg@gzhtcm.edu.cn
通讯作者：赖小平（1960- ），研究员，博士生导师。研究方向：中药新药研究与开发。Email：lxp88@gzhtcm.edu.cn
更新日期/Last Update: 1900-01-01