|本期目录/Table of Contents|

[1]林驰,王寅,叶永铭,等.电针治疗阻塞性睡眠呼吸暂停低通气综合征的P300临床研究[J].环球中医药,2012,5(02):108-0.
　LIN Chi,WANG Yin,YE Yong-ming..Observation on the electroacupuncture in treating obstructive sleep apnea hypoventilation syndrome and its impact on the P300 test[J].,2012,5(02):108-0.
点击复制

电针治疗阻塞性睡眠呼吸暂停低通气综合征的P300临床研究()
     
分享到：

《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第5卷
期数:
2012年02期
页码:
108-0
栏目:
论著
出版日期:
2012-02-06

文章信息/Info

Title:
Observation on the electroacupuncture in treating obstructive sleep apnea hypoventilation syndrome and its impact on the P300 test
作者:
林驰; 王寅; 叶永铭;
Author(s):
LIN Chi;  WANG Yin;  YE Yong-ming.
Acupuncture Department of Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053,China
关键词:
电针;  阻塞性睡眠呼吸暂停低通气综合征;  P300;  认知损害
Keywords:
Electroacupuncture;  Obstructive sleep apnea hypoventilation syndrome;  P300;  Cognitive impairment
分类号:
R246.1
DOI:
-
文献标志码:
A
摘要:
目的观察电针对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的临床疗效及其对患者认知功能的影响。方法本研究采用前瞻性、非对比性病例系列设计,利用多导睡眠监测评价疗效,利用观察病人认知变化。电针治疗22例OSAHS的连续病例,并于治疗前及治疗6周后进行多导睡眠监测和P300检测。同期对11例健康成人进行P300检测,观察P300指标稳定性。结果 22例OSAHS患者电针治疗后睡眠呼吸暂停低通气指数明显下降(P<0.05),最低血氧饱和度值明显上升(P<0.05),P300潜伏期及反应时间均明显缩短(P<0.01)。11例健康成人6周前后P300潜伏期及反应时间均无明显差异(P>0.05)。结论电针治疗OSAHS可减少睡眠时呼吸暂停和低通气次数,提高最低血氧饱和度,缩短P300潜伏期和反应时间,改善患者认知功能,对特殊职业的OS-AHS患者更有意义。
Abstract:
Objective To observe the clinical effects of electroacupuncture in treating obstructive sleep apnea hypoventilation syndrome(OSAHS)and the impact on the patients'cognitive function. Methods 22 patients with OSAHS were treated by electroacupuncture for six weeks as a course, and accepted two polysomnographies and two P300 tests prior to treatment and after 6-week treatment.At the same time, 11 healthy adults accepted no treatments but two P300 tests together with the patients. Result After the course of treatment, patients'Cz, Fz, Pz latency and P300 reaction time shortened(P<0.01). And the apnea hypopnea index reduced.(P<0.05)The lowest oxygen saturation increased.(P<0.05)The 11 healthy adults' P300 test results had no significant changes(P>0.05). Conclusion Electroacupuncture can reduce the apnea hypopnea index, increase the oxygen saturation, shorten P300 latency and reaction time of patients with OSAHS, and improve cognitive function. This therapy is more meaningful in treating patients with OSAHS of special occupations.

参考文献/References:

[1] 中华医学会呼吸病学分会睡眠呼吸疾病学组.阻塞性睡眠呼吸暂停低通气综合征诊治指南(草案)[J].中华结核和呼吸杂志,2002,25(4):195-198.
[2] Beebe D W,Groeaz L, Wells C,et al.The neuropsychological effects of obstructive sleep apnea:a meta-analysis of norm-referenced and case-controlled data[J].Sleep,2003,26(3):298-307.
[3] Findley I.J,Barth J T,Powers D C,et al.Cognitive impairment in patients with obstructive sleep apnea and associated hypoxemia[J].Chest,1986,90(5):686-690.
[4] Ansenne M.The P300 cognitive event-related potential: in the overical and psychobiogic perspective[J].Neurophysiol Clin,2000,30(1):191-192.
[5] Frodl T, Meisenzahl EM, Muller D, et al. P300 subcomponents and clinical symptoms in schizophrenia[J].Int J Psychophysiol,2002,43(3):237-246.
[6] 周立春.事件相关电位(P300)及其在癫痫中的应用[J].北京医学,1997,19(5):296-298.

相似文献/References:

[1]李小琴,高玉峰,于跃,等.电针对大鼠脊髓中抑制性生长因子的影响[J].环球中医药,2013,6(09):653.
　LI Xiao qin,GAO Yu feng,YU Yue,et al.Investigation of electro acupuncture therapy on inhibitory growth factor in rat spinal cord[J].,2013,6(02):653.
[2]武燕,李瑞,田环环,等.电针胃脘下俞对2型糖尿病模型大鼠血糖及血脂影响的实验研究[J].环球中医药,2013,6(10):737.
　WU Yan,LI Rui,TIAN Huan huan,et al.Experiment research on electroacupuncture of “Weiwanxiashu” affecting the content of blood sugar and Bloodlipoids in Type 2 Diabetes Rats[J].,2013,6(02):737.
[3]王天怡,李佳楠,宋坪,等.电针配合穴位注射治疗带状疱疹后遗神经痛30例[J].环球中医药,2013,6(11):865.
[4]李胜杰 李志同 杨伟宁等.电针上巨虚穴、尺泽穴对溃疡性结肠炎大鼠肺、肠肿瘤坏死因子 α 及结肠病理的比较研究[J].环球中医药,2014,7(06):415.
　LI Sheng jie,LI Zhi tong,YANG Wei ning,et al.Comparative study of electroacupuncture at Shangjuxu (ST 37) and Chize (LU 5) on TNFalpha content in the lung and colon and morphology of colonic mucosa in rats with ulcerative colitis[J].,2014,7(02):415.
[5]姚海江 莫雨平 宋洪涛等.电针对慢性应激抑郁模型大鼠松果体AANAT mRNA、HIOMT mRNA表达的影响[J].环球中医药,2014,7(07):511.
　YAO Hai-jiang,MO Yu-ping,SONG Hong-tao,et al.The effect of electro-acupuncture on the expression of AANAT mRNA and HIOMT mRNA in pineal of chronic stress depression model rats[J].,2014,7(02):511.
[6]彭园园,张莉,刘通等.电针“委中”穴对大鼠腰多裂肌损伤后的再生促进 作用及对IGF1表达的影响[J].环球中医药,2015,8(05):513.[doi:10.3969/j.issn.16741749.2015.05.001]
　PENG Yuan yuan,ZHANG Li,LIU Tong,et al.Effect of electroacupuncture at BL40 on morphology repairment and IGF1 expression in rats with multifidus muscle injury[J].,2015,8(02):513.[doi:10.3969/j.issn.16741749.2015.05.001]
[7]加吾拉·阿不力孜,王鑫,李芙等.观察电针“百会”、“涌泉”两穴对不同月龄APP/PS1 双转基因小鼠海马Aβ淀粉样沉淀及超微结构的 影响[J].环球中医药,2015,8(05):518.[doi:10.3969/j.issn.16741749.2015.05.002]
　Jiawula·Abulizi,WANG Xin,LI Fu,et al.Effect of electroacupuncture intervention on hippocampus Aβ stain and ultrastructure in APP/PS1 double transgenic rats[J].,2015,8(02):518.[doi:10.3969/j.issn.16741749.2015.05.002]
[8]于淼 张丹妹 邬继红 图娅 史榕荇 许明敏 郭郁 张旭辉 王瑜 张春涛 赵冰骢.电针对慢性应激抑郁模型大鼠海马神经血管生成相关蛋白的表达影响[J].环球中医药,2016,9(04):385.[doi:10.3969/j.issn.1674-1749.2016.04.001]
　YU Miao,ZHANG Dan-mei,WU Ji-hong,et al.Influence of electroacupuncture on the expression of related proteins in the hippocampus of rats with chronic stress induced depression[J].,2016,9(02):385.[doi:10.3969/j.issn.1674-1749.2016.04.001]
[9]白志冬,孟宪栋,魏千程,等.阻塞性睡眠呼吸暂停低通气综合征辨证治疗研究概述[J].环球中医药,2016,9(05):641.[doi:10.3969/j.issn.1674-1749.2016.05.034]
　BAI Zhi-dong,MENG Xian-dong,WEI Qian-cheng,et al.Research review of differential treatment in obstructive sleep apnea hypopnea syndrome[J].,2016,9(02):641.[doi:10.3969/j.issn.1674-1749.2016.05.034]
[10]赵正芳 唐纯志.电针关元、三阴交对痛经模型大鼠血清IL-2、5-HT及P物质的影响[J].环球中医药,2017,10(05):541.[doi:10.3969/j.issn.1674-1749.2017.05.007]
　ZHAO Zhengfang,TANG Chunzhi..Effect of electroacupuncture at Guanyuan(CV4)and Sanyinjiao(SP6)on serum IL-2, 5-HT and substance P in dysmenorrhea model rats[J].,2017,10(02):541.[doi:10.3969/j.issn.1674-1749.2017.05.007]

备注/Memo

备注/Memo:

作者单位：100053 北京市中国中医科学院广安门医院针灸科[林驰(硕士研究生)、叶永铭]; 北京中医药大学针灸推拿学院[林驰(硕士研究生)]; 广东省中山市中医院康复科(王寅)
作者简介：林驰(1986- ),女,2005级七年制在读硕士研究生。研究方向:针灸临床。E-mail:linchi86@yahoo.com.cn 通信作者:叶永铭(1970- ),女,硕士,副主任医师。研究方向:周围神经系统疾病和睡眠障碍针灸治疗。E-mail:huany_ym@yahoo.com.cn
更新日期/Last Update: 1900-01-01