[1]蔡乐,古今,项菲菲,等.正交试验法优选茜草配方颗粒的提取工艺[J].环球中医药,2012,5(04):269-0.
CAI Le,GU Jin,XIANG Fei fei,et al.Optimization of extraction technology of Rubia cordifolia L. for preparing formula granule by othogonal experiment[J].,2012,5(04):269-0.
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正交试验法优选茜草配方颗粒的提取工艺(
)
CAI Le,GU Jin,XIANG Fei fei,et al.Optimization of extraction technology of Rubia cordifolia L. for preparing formula granule by othogonal experiment[J].,2012,5(04):269-0.
)《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]
- 卷:
- 第5卷
- 期数:
- 2012年04期
- 页码:
- 269-0
- 栏目:
- 论著
- 出版日期:
- 2012-04-06
文章信息/Info
- Title:
- Optimization of extraction technology of Rubia cordifolia L. for preparing formula granule by othogonal experiment
- 作者:
- 蔡乐; 古今; 项菲菲; 刘萍;
- Author(s):
- CAI Le; GU Jin; XIANG Feifei; et al.
- TCM Department，PLA General Hospital，Beijing 100853，China
- Keywords:
- Rubia cordifolia L.; Formula granule; Extraction process; Orthogonal design; Rubimaillin; Purpurin
- 分类号:
- R284.2
- DOI:
- -
- 文献标志码:
- A
- 摘要:
- 目的 优选茜草配方颗粒的提取工艺。方法 以干浸膏得率、大叶茜草素和羟基茜草素提取量为评价指标,采用正交试验设计法考察加水倍量、提取次数和提取时间3个因素对提取效果的影响,通过综合评分筛选出茜草的最佳提取工艺。结果 提取次数对试验结果有极显著影响,加水倍量对提取工艺的影响有显著意义,而提取时间对结果无显著影响。综合考虑各因素的影响及生产实际需要,确定的最佳提取工艺为:茜草饮片加入10倍量水,煎煮提取3次,每次1小时。结论 该工艺条件提取充分,稳定可行,对茜草配方颗粒的生产具有一定的指导和参考意义。
- Abstract:
- ObjectiveTo optimize the extraction process of Rubia cordifolia L. formula granule. MethodsExtraction yields of solid drug, rubimaillin and purpurin were regarded as investigation index，and the amount of water, extraction times and duration on extraction were evaluated by orthogonal experimental design，and the best extraction process was statistically analyzed and screened by multiindex comprehensive evaluation method. ResultsExtraction times had the most notable effect on experimental results，and the amount of water was the secondary notable effect on the results，while the duration of extraction had no notable effects. Considering the effects of three factors and actual production process synthetically，the optimum condition of extraction process was that the decoction pieces were decocted three times in 10 folds water，one hour each time. ConclusionThe optimum extraction process was simple，reasonable and stable，which will have some instruction meaning and reference value to the production of Rubia cordifolia L. formula granule.
参考文献/References:
[1]高学敏.中药学［M］.北京：中国中医药出版社，2006：298.
[2］李云雁，胡传荣.实验设计与数据处理［M］.2版.北京：化学工业出版社，2008：134136.
[3］贾晓斌，黄丽霞，陈彦，等.中药配方颗粒标准化是临床疗效的基础［J］.中华中医药学刊，2008，26(6):12001202.
[4］蔡乐，刘萍，郭桂明，等.不同厂家茜草配方颗粒中大叶茜草素含量的比较［J］.北京中医药，2011，30(11):856858.
[5］谭朝阳，尤昭玲.茜草提取工艺的研究［J］.中草药，2004，35(4):339401.
[6］闫小平，郭宇洁，郑蕊，等.多指标综合评分法考察肠安Ⅰ号方醇提工艺［J］.中国实验方剂学杂志，2011，17(4):1215.
[7］张彤，徐莲英，陶建生，等.多指标综合评分法优选葛根提取工艺［J］.中草药，2004，35(1):3840
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备注/Memo
- 备注/Memo:
-
基金项目：四川新绿色药业合作课题
作者单位：100853北京，中国人民解放军总医院药品保障中心中药房
作者简介：蔡乐（1983- ），主管药师。研究方向：药剂学、医院药学。Email:caile15009@163.com
通讯作者：刘萍（1953- ），女，主任药师。研究方向：药剂学、临床药学。Email:liuping0707@yahoo.com.cn
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