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[1]袁名泽,刘桂芳,张家成,等.黄连素降糖量效关系实验研究概述[J].环球中医药,2012,5(06):469-0.
　YUAN Ming ze,LIU Gui fang,ZHANG Jia cheng,et al.Review about doseeffect relationship of berberine’s hypoglycemicexperiments[J].,2012,5(06):469-0.
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黄连素降糖量效关系实验研究概述()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第5卷
期数:
2012年06期
页码:
469-0
栏目:
综述
出版日期:
2012-06-06

文章信息/Info

Title:
Review about doseeffect relationship of berberine’s hypoglycemicexperiments
作者:
袁名泽; 刘桂芳; 张家成; 姬航宇; 赵林华; 周强; 仝小林; 李敏;
Author(s):
YUAN Mingze; LIU Guifang;  ZHANG Jiacheng;  et al.
Department of Endocrinology，Guang′anmen Hospital of China Academy of Chinese Medical Sciences,Beijing 100053, China
关键词:
黄连素;  量效关系;  中药;  综述;  实验
Keywords:
Berberine; Doseeffect relationship; Traditional Chinese medicine; Review; Experiment
分类号:
R285.5
DOI:
-
文献标志码:
A
摘要:
黄连素具有确切的降糖作用,而其降糖作用的量效研究集中于动物及细胞实验。本文通过系统回顾国内外关于黄连素在整体动物实验及细胞实验的降糖作用的量效研究。得出以下结论 :(1)动物实验中,剂量在40～200mg/kg之间,黄连素降糖作用具有量效关系; (2)细胞研究示,黄连素具有潜在肝毒性(浓度≥3μmol/L); (3)肠道可能是黄连素发挥作用的重要部位,可能导致细胞实验与动物实验剂量范围的差异。
Abstract:
Berberine has the exact hypoglycemic effect, and its hypoglycemic doseeffect studies have focused on animal and cell experiments. In this paper, a systematic review on a dose of the hypoglycemic effect of berberine in the animal and cellular experiments. In conclusion: animal experiments show that the hypoglycemic effect of berberine has doseeffect relationship between 40 mg/kg and 200 mg/kg; and cell researches show that berberine has the potential liver toxicity (≥3 μmol / L) ;intestine may be an important part of the berberine play a role, and may lead to the differences of the dose range between cell experiments and animal studies.

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相似文献/References:

[1]左茹 曹雪滨 张文生.黄连素药理作用研究进展[J].环球中医药,2014,7(07):568.
　ZUO Ru,CAO Xue-bin,ZHANG Wen-sheng.The progress of berberine's pharmacological effects[J].,2014,7(06):568.

备注/Memo

备注/Memo:
基金项目：国家重点基础研究发展计划(973计划）（2010CB530601）
作者单位：100053 北京，中国中医科学院广安门医院内分泌科[袁名泽(硕士研究生)、刘桂芳、张家成(硕士研究生)、姬航宇（博士研究生）、赵林华、周强（博士研究生）、仝小林、李敏]；北京中医药大学针灸推拿学院[袁名泽(硕士研究生)、张家成(硕士研究生)]
作者简介：袁名泽（1985- ），在读硕士研究生。研究方向：中西医结合糖尿病的基础与临床。Email：644064737@qq.com
通讯作者：李敏(1972- )，女，博士，研究员。研究方向：中西医结合糖尿病。Email：limin72114@163.com
更新日期/Last Update: 1900-01-01