|本期目录/Table of Contents|

[1]黄臻,温姗,颜芳,等.破格救心汤治疗严重心力衰竭安全性研究[J].环球中医药,2012,5(07):509-0.
　HUANG Zhen,WEN Shan,YAN Fang,et al.Clinical study on security effects of Poge Jiuxin Decoction treating patients with congestive heart failure[J].,2012,5(07):509-0.
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破格救心汤治疗严重心力衰竭安全性研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第5卷
期数:
2012年07期
页码:
509-0
栏目:
论著
出版日期:
2012-07-06

文章信息/Info

Title:
Clinical study on security effects of Poge Jiuxin Decoction treating patients with congestive heart failure
作者:
黄臻; 温姗; 颜芳; 梁伟雄; 徐国峰; 陈党红; 孙良生; 张锦祥; 邓贤斌; 曾祥珲; 罗士针; 原嘉民;
Author(s):
HUANG Zhen;  WEN Shan;  YAN Fang;  et al.
Guangdong Provincial Hospital of Traditional Chinese Medicine Classic Clinical Application of Base, Guangzhou 510370, China
关键词:
破格救心汤;  心力衰竭;  安全性
Keywords:
Poge Jiuxin Decoction;  Congestive heart failure;  Security
分类号:
R541.6
DOI:
-
文献标志码:
A
摘要:
目的破格救心汤中破格重用超常规剂量的附子以治疗严重心力衰竭,本研究通过临床观察探讨其用药安全性。方法采用前瞻性、同期、开放、对照试验设计,选择54例符合入选标准的严重心力衰竭患者分别进入常规治疗组和破格救心汤组,常规治疗组给予抗心衰标准治疗,破格救心汤组在此基础上加用破格救心汤,疗程2～3周。观察两组患者用药前后的生命体征、全血细胞分析、肝功能(谷丙转氨酶、谷草转氨酶)、肾功能(尿蛋白、尿素、肌酐),持续心电监测,判断不良事件,采集安全性数据。结果破格救心汤组治疗过程中未出现附子中毒症状,治疗后复查血常规、肝肾功能无异常,治疗全程无异常心电波动,未出现严重不良反应。结论破格救心汤治疗严重心力衰竭具有良好的安全性。
Abstract:
Objective Observation of clinical safety in patients with chronic cardiac insufficiency(heart function grade Ⅲ-Ⅳ)patients for heart failure treatment with the additional treatment of taking Poge Jiuxin Decoction.Methods This is a pioneering study. Over the same time period, using an open, non-randomized controlled trial design, 54 subjects who met the inclusion criteria were selected who were experiencing an acute exacerbation of their chronic heart failure condition. They were divided into the treatment group or the control group. The control group was given standard conventional therapy for 2-3weeks; the treatment group was given Poge Jiuxin Decoction in addition to standard conventional therapy. Safety information data were taken.Results Our clinical research shows that blood cell analysis and the liver and kidney function are normal, no abnormal ECG fluctuations, no significant adverse events in the 34 cases taking Poge Jiuxin Decoction.Conclusion In congestive heart failure, Poge Jiuxin Decoction is safe.

参考文献/References:

[1] 余武强.中西医结合治疗慢性肺心病心衰疗效观察[J].中国当代医药,2011,18(8):93-94.
[2] 肖艳.破格救心汤治疗急性心肌梗死临床观察[J].山西中医,2010,26(9):12-13.
[3] 余武强.中西医结合治疗急性心肌梗死并心源性休克1OO例[J].中国医药指南,2011:9(5):145-146.
[4] 中华心血管病杂志编辑委员会.全国心力衰竭诊断与治疗专题研讨会纪要[J].中华心血管病杂志,1995,23(2):95-100.
[5] 中华医学会心血管病学分会、中华心血管病杂志编辑委员会.慢性收缩性心力衰竭治疗建议[J].中华心血管病杂志,2002,30(1):7-23.
[6] 郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:77-85. (收稿日期: 2012-04-23)

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备注/Memo

备注/Memo:
基金项目:广东省中医药局2010年建设中医药强省科研课题(2010383)
作者单位：510370 广州,广东省中医院中医经典临床应用研究基地[黄臻(博士研究生)、温姗、颜芳、徐国峰、陈党红、孙良生、张锦祥、邓贤斌、曾祥珲、罗士针];.广东省中医院GCP办公室(梁伟雄); 广州中医药大学[原嘉民(硕士研究生)]
作者简介：黄臻(1977- ),女,2008级在读博士研究生,主治医师。研究方向:中医药综合疗法治疗急危重症及疑难杂症。E-mail:13610140005@139.com
更新日期/Last Update: 1900-01-01