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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:

第5卷

期数:

2012年08期

页码:

573-0

栏目:

论著

出版日期:

2012-08-06

文章信息/Info

Title:

Influence of Qingre Jiedu Decoction on TNF-α,IL-1,IL-6 in type 2 diabetic rats

作者:

冯建华; 李洁; 王殿云; 张萌; 刘媛; 李国霞;

Author(s):

FENG Jian-hua;  LI Jie;  WANG Dian-yun;  et al.

Department of Endocrinology,the Second Affiliated Hospital of Shandong University of Chinese Medicine, Jinan 250001,China

关键词:

清热解毒方;  2型糖尿病;  炎症因子;  大鼠

Keywords:

Qingre Jiedu Decoction;  Type 2 diabetes;  Inflammatory factors;  Rat

分类号:

R285.5

DOI:

-

文献标志码:

A

摘要:

目的观察清热解毒方对2型糖尿病大鼠血清肿瘤坏死因子-α(TNF-α)、白介素-1(IL-1)、白介素-6(IL-6)水平的影响。方法采用小剂量链脲佐菌素(STZ)加高脂饮食饲养的方法建立2型糖尿病(DM)肥胖大鼠模型,随机分为正常对照组,模型组,中药高剂量组,中药低剂量组,二甲双胍组。给药4周后观察大鼠血清TNF-α、IL-1、IL-6水平的变化。结果与模型组相比,中药组血糖、血清TNF-α、IL-1、IL-6水平明显下降(P<0.05),中药高低剂量组之间无明显差异,中药组与二甲双胍组相比有显著差异(P<0.05)。结论清热解毒方可明显降低2型糖尿病模型大鼠血清中的炎症因子水平。

Abstract:

Objective To study the influence of Qingre Jiedu Decoction on type 2 diabetic rat serum tumor necrosis factor-α and interleukin-6 levels. Methods To establish type 2 diabetic obese rat model by injecting with low dose of STZ and high-fat diet feeding. Then the rats were randomly divided into model group, high dose of Chinese medicine, low dose of Chinese medicine and metformin group. After 4 weeks drug delivery, the levels of tumor necrosis factor-α and interleukin-6 in the rat serum were measured. Results Compared with the model group, the serum tumor necrosis factor-α and interleukin-6 levels of Chinese medicines groups were decreased significantly. There is no significantly difference between the two groups of traditional Chinese medicine group. There is a significant difference between the metformin group and the TCM group. Conclusion Qingrejiedu Decoction can significantly reduce the levels of tumor necrosis factor-α and interleukin-6 in the serum of T2DM rat.

参考文献/References:

[1] Schmidt MI,Duncan BB,Scharret AR. et al.Markers of inflammation and prediction of diabetes mellitus in adults(Atherosclerosis Risk in Communities study):a cohort study[J].Lancet,1999,353(9165):1649-1652.
[2] Barzilay JI,Abraham L,Heckbert SR,et al.The relation of markers of inflammation to the development of glucose disorders in the elderly:the Cardiovascular Health Study[J].Diabetes,2001,50(10):2384-2389.
[3] Pradhan AD,Manson JE, Rifai N,et a1.C-reactive protein. interleukin 6,and risk of developing type 2 diabetes mellitus[J].Jama,2001,286(3):327-334.
[4] Srinivasan K, Viswanad B, Asrat L, et al. Combination of high-fat diet-fed and low-dose strep tozotocin-treated rat: a model for type 2 diabetes and pharmacological screening[J]. Pharmacol Res, 2005,52(4): 313-320.
[5] 周迎生,高妍,李斌,等.高脂喂养联合链脲佐菌素注射的糖尿病大鼠模型特征[J].中国实验动物学报,2005,13(3):154-158.
[6] O'Doherty R, Stein D, Foley J. Insulin resistance[J].Diabetologia, 1997,40(suppl3):B10-5.
[7] 张萌,冯建华,张昭.清解合剂对2型糖尿病炎症因子水平的影响[J].山东中医药大学学报,2009,33(6):486-488.

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备注/Memo

备注/Memo:

基金项目:国家自然科学基金(30772799)
作者单位：250001 济南,山东中医药大学第二附属医院内分泌科(冯建华、刘媛、李国霞); 山东中医药大学基础实验室(李洁、张萌); 山东中医药大学[王殿云(硕士研究生)]
作者简介：冯建华(1950- ),教授,主任医师,博士生导师。研究方向:中医药防治内分泌代谢性疾病临床研究。E-mail:jhfeng@126.com

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