|本期目录/Table of Contents|

[1]王景,田国庆,梁晓春,等.糖尿病前期患者101例中医证候特点及相关指标分析[J].环球中医药,2012,5(11):808-0.
　WANG Jing,TIAN Guo qing,LIANG Xiao chun,et al.Analysis on TCM syndrome and related data in 101 cases of prediabetes[J].,2012,5(11):808-0.
点击复制

糖尿病前期患者101例中医证候特点及相关指标分析()
     
分享到：

《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第5卷
期数:
2012年11期
页码:
808-0
栏目:
论著
出版日期:
2012-11-06

文章信息/Info

Title:
Analysis on TCM syndrome and related data in 101 cases of prediabetes
作者:
王景; 田国庆; 梁晓春; 张孟仁; 尹德海; 朴元林; 潘明政; 李化萍;
Author(s):
WANG Jing; TIAN Guoqing; LIANG Xiaochun; et al.
Ｄepartment of TCM, Peking Union Medical College Hospital，Peking Union Medical College，Chinese Academy of Medical Sciences，Beijing 100730，China
关键词:
糖尿病前期;  中医证候;  证候特点;  指标分析;  临床研究
Keywords:
Prediabetes; TCM syndromes; Syndrome characteristics; Data analysis; Clinical study
分类号:
R587.1
DOI:
-
文献标志码:
A
摘要:
目的分析糖尿病前期患者的中医临床证候分布特点,初步探索不同证候组患者体重指数、腰臀比、胰岛素抵抗指数、β细胞胰岛素分泌指数等指标的变化规律。方法中医临床症状采用5级记分法,结合舌脉进行中医辨证,检测不同证候组患者的口服葡萄糖耐量试验(OGTT)血糖及血真胰岛素水平、糖化血红蛋白、血脂等,计算体重指数、腰臀比、早期胰岛素分泌指数、胰岛素抵抗指数、β细胞胰岛素分泌指数,采用统计学方法对上述数据进行分析处理。结果在101例糖尿病前期患者中,证候分为气阴两虚血瘀证、气虚痰湿证、阴虚证、气滞证,以气阴两虚血瘀证最多见。其中气虚痰湿证组的体重指数、腰围、腰臀比均高于其他三组,经统计学处理有显著性差异(P<0.05)。四个证候组OGTT、血糖水平、胰岛素抵抗指数、β细胞胰岛素分泌指数、血脂等指标存在一些变化,OGTT血真胰岛素水平差异不大,早期胰岛素分泌指数、糖化血红蛋白水平比较均无差异(P>0.05)。结论糖尿病前期患者的中医临床证候以气阴两虚血瘀证多见,气虚痰湿证组患者的胰岛素抵抗更为严重,上述不同证候的糖尿病前期患者第一时相胰岛素分泌功能基本相似。
Abstract:
ObjectiveTo observe the distribution characteristics of TCM clinical syndromes in 101 cases of prediabetes and explore the variation of the data such as body mass index（BMI），waisthip ratio（WHR），homeostatic model assessment of insulin resistance index（HOMAIR）and βcell insulin secretion index（MBCI） in patients with different syndromes. MethodsThe syndrome differentiation and classification of TCM were made in the cases according to TCM clinical symptoms，tongues and pulses. The data of each syndrome patient such as OGTT blood glucose，OGTT blood insulin，glycosylated hemoglobin（HbA1c），blood fat（TC，TG，LDLC，HDLC）were detected.The BMI，WHR，earlyphase insulin secretion index（△I30/△G30），HOMAIR and MBCI of each patient were calculated. And all above data were analyzed by using statistical methods. ResultsIn 101 patients with prediabetes，the syndromes were deficiency of both qi and yin blood stasis syndrome，qi deficiency and phlegmdamp syndrome，yin deficiency syndrome，qi stagnancy syndrome，and the deficiency of both qi and yin blood stasis syndrome was the most common syndrome. Compared with the other three groups，the BMI，waistline，WHR of qi deficiency and phlegmdamp syndrome increased significantly (P<0.05).Among the four syndrome groups，there is some difference in the OGTT blood glucose，HOMAIR，MBCI and blood fat level，and there is little difference in the OGTT blood insulin， and there is no difference in the levels of △I30/△G30 and HbA1c (P>0.05). ConclusionsIn the prediabetes，the most common TCM clinical syndrome is deficiency of both qi and yin blood stasis syndrome. The insulin resistance of qi deficiency and phlegmdamp syndrome group is more severe than the others. Among the different syndrome groups，the first phase insulin secretions in patients with prediabetes are similar.

参考文献/References:

[1]King H，Rewers M. Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults[J]．Diabete Care，1993，16（1）：157177.
[2]陈家伦．循证医学对糖尿病诊断的贡献及其目前存在的分歧[J]．中华内分泌代谢杂志，2003，19(1)：14．
[3]Yang W, Lu J, Weng J, et al. Prevalence of Diabetes among Men and Women in China[J]. N Engl J Med，2010，362（12）：10901101.
[4]郑筱萸．中药新药临床研究指导原则[S].北京：中国医药科技出版社，2002：233 237.
[5]黎明，吴从愿，宋爱玲，等．人血清真胰岛素酶联免疫法的建立及初步应用[J]．中华内分泌代谢杂志，1997，13(3)：214217.
[6]Pratey RE，Weyer C.Theroleofim therole of impaired early insulin secretion in the pathogenesis of type2 diabetes mellitus[J].Diabeto1ogia，2001，44 (8)：929945.
[7]Matthews DR，Hosker JP．Rudenski AS，et al.Homeostasis model assessment：insulin resistance and β cell function from fasting plasma glucose and insulin concentrations in man[J].Diabetologia，1985，28：412419．
[8]李光伟.对胰岛β细胞功能评估的再认识[J].国外医学内分泌分册，2005，25(3)：164166.
[9]李学军，吴洁，郭灵祥，等.159例糖调节受损患者中医证候研究[J]．中医杂志，2008，49 (12)：11061108.
[10]王琳，朱德增，张杰，等．上海市延吉社区糖调节受损人群的中医证候调查[J].河北中医，2011，33(6):819821.
[11]林兰.内分泌代谢病中西医结合研究临床与基础[M]．北京：军事医学科学出版社， 2010：8592.
[12]谭震华，李学军，吴杰，等.糖调节受损者之中医痰湿证研究[J].光明中医，2008，23（7）：893895.
[13]赵永莉，叶山东，陈燕，等.正常糖耐量、糖耐量受损及新诊断2型糖尿病人群胰岛β细胞功能的变化[J].中华糖尿病杂志，2005，13（1）：1718.

相似文献/References:

[1]杨晋翔,来要良.酒精性肝纤维化中医证候研究评述[J].环球中医药,2012,5(04):310.
　YANG Jin xiang,LAI Yao liang..Review of TCM syndromes of alcoholic liver fibrosis[J].,2012,5(11):310.
[2]郑洪光,石燕萍,李秀兰,等.糖尿病合并高血压病中医证候分布调查[J].环球中医药,2012,5(09):684.
[3]赵铁牛,杨晓南,王惠君,等.基于结构方程模型的中医证候学研究概述[J].环球中医药,2012,5(11):862.
　ZHAO Tie niu,YANG Xiao nan,WANG Hui jun,et al.Summary on the study of traditional Chinese medicine syndrome based on structural equation model[J].,2012,5(11):862.
[4]齐铮,赵进喜,王硕仁,等.糖尿病肾病中医证候分布规律的文献研究[J].环球中医药,2012,5(12):914.
　QI Zheng,ZHAO Jin-xi,WANG Shuo-ren,et al.Distribution regules on syndrone of diabetic nephropathy[J].,2012,5(11):914.
[5]王志斌 韩海啸 余轶群等.幽门螺杆菌根治率与慢性胃炎中医证型的相关性研究[J].环球中医药,2014,7(07):523.
　WANG Zhi-bin,HAN Hai-xiao,YU Yi-qun,et al.Correlation of TCM syndromes and H.pylori eradication rate of chronic gastritis patients[J].,2014,7(11):523.
[6]吴爱明,赵明镜,张冬梅,等.高血压病患者血清白介素6对缺血性中风诊断和辨证的临床意义探讨[J].环球中医药,2015,8(04):399.[doi:10.3969/j.issn.1674-1749.2015.04.004]
　WU Ai-ming,ZHAO Ming-jing,ZHANG Dong-mei,et al.Discussion on the clinical value of serum interleukin- 6 for the diagnosis and syndrome differentiation of ischemic stroke in patients with hypertension[J].,2015,8(11):399.[doi:10.3969/j.issn.1674-1749.2015.04.004]
[7]王文婷 张厂 王林恒 李军祥 胡立明 孟捷 韩海啸 王志斌 陈润花 余轶群 赵薇巍 彭丹.胃食管反流病中医证候学研究探索[J].环球中医药,2016,9(08):931.[doi:10.3969/j.issn.1674-1749.2016.08.007]
　WANG Wen-ting,ZHANG Chang,WANG Lin-heng,et al.Clinical study on the traditional Chinese medicine syndromes of the gastroesophageal reflux disease[J].,2016,9(11):931.[doi:10.3969/j.issn.1674-1749.2016.08.007]
[8]阮越勇,王蓓蕾,李想,等.慢性阻塞性肺疾病稳定期中医证候与理化检测指标的相关性研究[J].环球中医药,2017,10(04):401.[doi:10.3969/j.issn.1674-1749.2017.04.005]
　RUAN Yueyong,WANG Beilei,LI Xiang,et al.Relevant research of TCM syndrome and physical and chemical detection index of stable COPD[J].,2017,10(11):401.[doi:10.3969/j.issn.1674-1749.2017.04.005]
[9]郭晓媛 王暴魁.肾脏病微观辨证的理论探讨[J].环球中医药,2017,10(09):961.[doi:10.3969/j.issn.1674-1749.2017.09.007]
　GUO Xiaoyuan,WANG Baokui..Theoretical discussion of the micro syndrome differentiation of kidney disease[J].,2017,10(11):961.[doi:10.3969/j.issn.1674-1749.2017.09.007]
[10]李昕原,梁腾霄,王兰.侵袭性肺部真菌感染的中医证素特点研究[J].环球中医药,2017,10(10):1074.[doi:10.3969/j.issn.1674-1749.2017.10.004]
　LI Xinyuan,LIANG Tengxiao,WANG Lan..Study on the characteristics of TCM syndrome factors of invasive pulmonary fungal infection[J].,2017,10(11):1074.[doi:10.3969/j.issn.1674-1749.2017.10.004]
[11]李化萍,梁晓春.糖尿病前期人群中医证候特点及干预的研究概况[J].环球中医药,2012,5(10):785.
　LI Hua ping,LIANG Xiao chun..Prediabetes crowd of TCM syndrome characteristics and the general research situation of intervention[J].,2012,5(11):785.

备注/Memo

备注/Memo:
基金项目：首都医学发展基金（SF2007III29）
作者单位：中国医学科学院 北京协和医学院 北京协和医院中医科
作者简介：王景（1977- ），女，本科，主治医师。研究方向：中西医结合治疗糖尿病及其慢性并发症。Email：wj8039@gmail.com
通讯作者：田国庆（1968- ），博士，主任医师。研究方向：中西医结合治疗糖尿病及其慢性并发症。Email：gqtian@163.com
更新日期/Last Update: 1900-01-01