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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:

第5卷

期数:

2012年12期

页码:

896-0

栏目:

中医心脑血管疾病研究

出版日期:

2012-12-06

文章信息/Info

Title:

Clinical research of Xinshuai No.1 Granule in treating chronic systolic heart failure

作者:

赵惠; 李七一;

Author(s):

ZHAO Hui;  LI Qi-yi.

Department of Cardiology,Jiangsu Province Hospital of TCM, Nanjing 210029, China

关键词:

心衰Ⅰ号;  益气养阴;  活血化痰;  慢性收缩性心力衰竭;  疗效

Keywords:

Xinshuai No.1 Granule;  Tonifying Qi and nourishing Yin;  Activating blood and resolving phlegm;  Chronic systolic heart failure;  Effective rate

分类号:

R541.6+1

DOI:

-

文献标志码:

A

摘要:

目的观察心衰Ⅰ号配方颗粒对慢性收缩性心力衰竭临床疗效。方法将120例慢性收缩性心力衰竭患者随机分为治疗组与对照组,每组60例,两组均应用血管紧张素转化酶抑制剂,可与利尿剂、β受体阻滞剂和(或)地高辛合用,血管紧张素Ⅱ受体阻滞剂可用于不能耐受血管紧张素转化酶抑制剂的患者,近期或目前为NYHAⅣ级患者可考虑应用小剂量螺内酯20mg/天。在此基础上治疗组口服心衰Ⅰ号,每日60.5g,分2次服,对照组口服心衰Ⅰ号安慰剂,每日60.5g,分2次服。观察时间为24周。比较两组治疗后症状体征、生活质量评分、脑钠肽、左室射血分数、6分钟步行试验的变化和综合疗效。结果综合疗效治疗组总有效率为67.24%,对照组总有效率为45.61%,经χ2检验治疗组优于对照组(P<0.05); 两组治疗前症状体征积分为治疗组(16.10±3.70)分、对照组(15.53±3.28)分,治疗后治疗组(7.76±4.95)分、对照组(10.16±4.38)分,经t检验治疗组优于对照组(P<0.01); 治疗前脑钠肽为治疗组(664.30±610.0)ng/dl、对照组(640.09±263.60)ng/dl,治疗后治疗组(271.97±180.20)ng/dl、对照组(458.15±640.84)ng/dl,经t检验治疗组优于对照组(P<0.05)、治疗前左室射血分数为治疗组(38.75±5.90)%、对照组(37.18±6.59)%,治疗后治疗组(46.01±7.36)%、对照组(42.06±8.11)%,经t检验治疗组优于对照组(P<0.05); 治疗前6分钟步行试验为治疗组(434.86±170.65)米、对照组(475.53±132.10)米,治疗后治疗组(700.85±154.44)米、对照组(593.25±130.99)米,经t检验治疗组优于对照组(P<0.05); 治疗前生活质量积分为治疗组(53.95±10.32)分、对照组(51.25±13.30)分,治疗后治疗组(43.61±9.36)分、对照组(42.29±10.81)分,经t检验治疗组与对照组无差异(P>0.05),治疗期间两组均无不良反应发生。结论心衰Ⅰ号长期治疗慢性收缩性心力衰竭患者安全有效。

Abstract:

Objective To evaluate therapeutic effect of Xinshuai No.1 Granule in treating chronic systolic heart failure(CHF). Methods 120 patients with the CHF were randomly divided into treatment group and control group, 60 cases for each group. Both groups used the standard treatment by using the ACE which can be used with the hydragogue,the beta-blocker, and the digoxin. The ARB could be used if the patients were not able to endure the ACE and the spirolactone could be considered to use 20 mg per day if the patients are NYHA Ⅳ recently.Treatment group was treated with Xinshuai No.1 granule at same time, twice a day for 1 bag. The control group was treated with placebo, twice a day for 1 bag. Four weeks was one course of treatment and 6 courses were observed.The changeeof signs and symptoms, quality of life score, brain natriuretic peptide, left ventricular ejection fraction, the 6-minute walk test and comprehensive efficacy were compared between two groups.Results The total effective rate of treatment group wase(P<0.05), with 67.24%, 45.61% respectively.The signs and symptoms, comprehensive efficacy, brain natriuretic peptide, left ventricular ejection fraction, the 6-minute walk test and comprehensive fficacy and other indexes of two groups had significantly improved after treatment(P<0.05). There were no adverse events during treatment in two groups. Conclusion Xinshuai No.1 Granule is safe and effectiveeNo.1 granule to teat CHF patients in long term.

参考文献/References:

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相似文献/References:

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备注/Memo

备注/Memo:

基金项目:国家中医药管理局中医药科技项目(04-05LP025)
作者单位：210029 南京,江苏省中医院心内科
作者简介：赵惠(1968- ),女,中医博士,副主任中医师。研究方向:中医心血管疾病。E-mail:say3637@163.com
通讯作者：李七一(1951- ),教授,主任医师,博士生导师。研究方向:中医心血管疾病,疑难杂症。E-mail:liqiyi0701@yahoo.cn

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