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[1]彭金玲,边育红,王丽,等.马兜铃酸肾毒性的研究进展[J].环球中医药,2013,6(01):59-0.
　PENG Jin ling,BIAN Yu hong,WANG Li,et al.Research progress of Aristolochic acid renal toxicity[J].,2013,6(01):59-0.
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马兜铃酸肾毒性的研究进展()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第6卷
期数:
2013年01期
页码:
59-0
栏目:
综述
出版日期:
2013-01-06

文章信息/Info

Title:
Research progress of Aristolochic acid renal toxicity
作者:
彭金玲;边育红;王丽;李金奎;
Author(s):
PENG Jinling; BIAN Yuhong; WANG Li; et al.
Immunization Branch, Second People’s Hospital of EPI, Fengrun District, Tangshan City, Hebei Province,Tangshan 063400,China
关键词:
马兜铃酸; 肾毒性; 马兜铃酸肾病; 发病机制
Keywords:
Aristolochic acid; Renal toxicity; Aristolochic acid nephropathy; Pathogenesis　
分类号:
R96
DOI:
-
文献标志码:
A
摘要:
马兜铃酸(AA)为硝基菲类有机酸类化合物,是马兜铃、关木通、细辛、广防己等植物的主要成分。马兜铃酸药理作用广泛,有抗感染、抗癌、增强细胞免疫及终止妊娠等功能。目前,含有马兜铃酸的中药或中成药广泛应用于风湿及泌尿系统等多种疾病,由于服用含有马兜铃酸成分的中药而引起的肾脏损害报道日益增加,马兜铃酸肾毒性作用越来越受到人们的重视。本文总结了近年来马兜铃酸化学结构、毒理作用基础及临床研究,并对其肾毒理作用机制进行综述,使其为临床合理应用含有马兜铃酸的中药或中成药制剂提供参考。通过设计安全有效的药用剂型,严格控制用药剂量和时间,避免长期或大剂量服用,预防并减少毒性作用,将使该药在临床上得到更广泛应用。
Abstract:
Aristolonic acid is a nitro phenanthrene organic acid compound found as a main component of Aristolochia, Guan mutong, Asarum, Aristolochia Fangchi and many other medicinal plants. Aristolochic acid is widely used in the pharmaceutical industry due to its anti infection, anti tumor, abortifacient and cellular immunity enhancing properties. Present uses of Aristolochic acid containing Chinese medicine are for the treatment of rheumatic and urinary system diseases. However, there have been increased reports on kidney damage as a result of using Aristolochic acid containing drugs, which, leads to increased research in the field. It is necessary and crucial to provide proper reference for safer clinical use of Chinese traditional medicines with Aristolochic acid components. This paper therefore focuses on the structure, toxicological effects and clinical applications of Aristolochic acid as well as its renal toxicological mechanisms. We therefore conclude that, due to the beneficial medicinal properties of Aristolochic acid, it is necessary to design a safer and effective pharmaceutical dosage formulation and strictly control drug dose and time as well as duration of drug use in order to reduce its toxic effect, thereby increasing its clinical application.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81072741）
作者单位：063400 河北省唐山市丰润区第二人民医院计划免疫科(彭金玲)；天津中医药大学中医学院免疫教研室(边育红)；天津市传染病医院制剂科（王丽）；新探健康发展研究中心控烟项目办公室（李金奎）
作者简介：彭金玲（1968- ），本科，主治医师。研究方向：流行病学。Email：chaihuogun0423@yahoo.com.cn
通讯作者：边育红（1968- ），博士，硕士生导师，教授。研究方向：干细胞、表观遗传学。Email：bianyuhong_2012@163.com
更新日期/Last Update: 1900-01-01