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[1]汤久慧 张丽萍 吴沛然 颜红.加味温胆汤与氟西汀治疗抑郁症的临床对照 研究[J].环球中医药,2013,6(04):253-257.
　TANG Jiu hui,ZHANG Li ping,WU Pei ran,et al.Controlled clinical studies of treating depression between Jiawei Wendan Decoction and Fluoxetine[J].,2013,6(04):253-257.
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加味温胆汤与氟西汀治疗抑郁症的临床对照 研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第6卷
期数:
2013年04期
页码:
253-257
栏目:
论著
出版日期:
2013-04-06

文章信息/Info

Title:
Controlled clinical studies of treating depression between Jiawei Wendan Decoction and Fluoxetine
作者:
汤久慧 张丽萍 吴沛然 颜红
作者单位：300073 天津中医药大学人文管理学院［汤久慧(硕士研究生)、张丽萍、吴沛然(硕士研究生)］；天津中医药大学附属第一医院心身科（颜红）
Author(s):
TANG Jiuhui;  ZHANG Liping;  WU Peiran;  et al.
Humanistic Management Institute of Tianjin University of Traditional Chinese Medicine, Tianjin 300073, China
Corresponding author: TANG Jiuhui, Email: xiaozhanbb@163.com
关键词:
抑郁症;  加味温胆汤;  氟西汀;  临床观察
Keywords:
Depression; Jiawei Wendan Decoction; Fluoxetine; Clinical observation
分类号:
R749.4
DOI:
-
文献标志码:
-
摘要:
目的对比观察加味温胆汤与氟西汀治疗抑郁症的临床疗效。方法将60例抑郁症患者随机分为中药组和对照组，对照组30例给予盐酸氟西汀胶囊，中药组30例给予加味温胆汤，疗程均为6周。治疗前及治疗2周后、4周后、6周后采用汉密尔顿抑郁量表（Hamilton depression scale, HAMD）、中医症候量表进行评分；治疗前后采用神经心理学测验评价执行功能变化以及6周末采用抗抑郁药副反应评定量表（rating scale for side effects, SERS）评价不良情况。结果治疗6周后，两组患者临床疗效相当，可明显改善治疗前HAMD评分，两组未显示统计学差异（P＞0.05）；中药组从治疗4周后开始对中医证候具有明显改善作用，与对照组有明显差异，有统计学意义（P＜0.05）；6周末两组的基本执行功能总分值存在差异（P＜0.05），有统计学意义，主要表现在威斯康星卡片分类测验（Wisconsin card sorting test, WCST）总正确数、汉诺塔测验（tower of Hanoi, TOH）平均计划时间、连线测试（trail making testB, TMTB）错误数方面中药组得分高于对照组；6周末中药组的（SERS量表评分）不良反应发生率（13.4%）明显低于对照组（30.4%）。结论加味温胆汤对抑郁症具有良好的临床治疗效果。
Abstract:
ObjectiveTo investigate curative effect of treating depression with Jiawei Wendan Decoction and fluoxetine respectively. Methods60 depression patients were randomly divided into traditional Chinese medicine group and control group. 30 patients of control group were treated with Fluoxetine; 30 patients of traditional Chinese medicine group were treated with Jiawei Wendan Decoction. Both groups were treating 6 weeks as a course of treatment. To evaluate curative effect and side effect, Hamilton depression (HAMD) scale score and traditional Chinese medicine (TCM) syndromes were measured in both groups at the end of the 0th, the 2nd, 4th, 6th week; neuropsychological tests were measured in both groups before and after treatment; rating scale for side effects (SERS) was checked in both groups at the end of 6th week. ResultsAt the end of the 6th week, we found that there were no significant differences between the two groups (P＞0.05) in the curative effect and the scores of HAMD; and, the changes differences of TCM symptoms between two groups were significant (P＜0.05) from the 4th week; and in the traditional Chinese medicine group the scores of basic neurocognitive functioning, such as the continue errors of Wisconsin card sorting test (WCST), total scores of tower of Hanoi (TOH), errors of trail making testB(TMTB), were obviously higher than the control group (P＜0.05). However, at the end of 6th week, the extent of adverse reaction (rating scale for side effects, SERS) in the traditional Chinese medicine group (13.4%) was lower than that in the control group (30.4%). ConclusionJiawei Wendan Decoction has a good curative effect in treating depression.

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备注/Memo

备注/Memo:
作者简介：汤久慧（1986- ），女，2011级在读硕士研究生。研究方向：情志疾病的中医药防治。Email: xiaozhanbb@163.com
更新日期/Last Update: 2013-04-30