|本期目录/Table of Contents|

[1]许卫华 李妮矫 张艳丽 柯美云 姚树坤.不同中医证型功能性消化不良患者核素胃排空 特点的研究[J].环球中医药,2013,6(05):321-324.
　XU Wei hua,LI Ni jiao,ZHANG Yan li,et al.Study of radionuclide gastric emptying on different TCM syndrome types in patients with functional dyspepsia[J].,2013,6(05):321-324.
点击复制

不同中医证型功能性消化不良患者核素胃排空 特点的研究()
     
分享到：

《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第6卷
期数:
2013年05期
页码:
321-324
栏目:
论著
出版日期:
2013-05-06

文章信息/Info

Title:
Study of radionuclide gastric emptying on different TCM syndrome types in patients with functional dyspepsia
作者:
许卫华 李妮矫 张艳丽 柯美云 姚树坤
作者单位：100029北京中医药大学［许卫华（博士研究生）］；中日友好医院消化内科（姚树坤、张艳丽），中医消化科（李妮矫）；北京协和医院消化内科（柯美云）
Author(s):
XU Weihua; LI Nijiao; ZHANG Yanli; et al.
Beijing University of TCM，Beijing 100029，China
Corresponding auther：YAO Shukun，Email：yaoshukun6 @yahoo.com.cn
关键词:
功能性消化不良; 湿热壅滞证; 脾虚气滞证; 肝胃气滞证; 肝胃郁热证; 核素胃排空试验
Keywords:
Functional dyspepsia; Stagnation of dampheat type; Spleen deficiency and Qi stagnation type; Liver and stomach Qi stagnation type; Stagnation of heat in liver and stomach type; Radionuclide gastric emptying test
分类号:
R573
DOI:
-
文献标志码:
-
摘要:
目的探讨不同中医证型功能性消化不良（functional dyspepsia，FD）患者核素胃排空的特点。方法将多中心的84例FD患者分为湿热壅滞证、脾虚气滞证、肝胃气滞证和肝胃郁热证四组，并进行核素胃排空检查，分析比较不同中医证型的胃半排空时间、胃排空速率、2小时存留率。结果（1）84例FD患者中，胃排空延迟者46例（548%），胃排空正常者38例（452%）；（2）胃半排空时间肝胃气滞型最长（1407±553）分钟，其次为脾虚气滞型(1343±646)分钟，肝胃郁热证（1187±274）分钟，湿热壅滞型最短(1008±267)分钟，经方差分析各证型之间差异有统计学意义（P＜005）；湿热壅滞证与肝胃气滞证、脾虚气滞证两两比较差异有统计学意义（P＜005）。（3）胃排空速率经方差分析比较发现，不同中医证型之间差异有统计学意义(P＜005)；湿热壅滞型最高（053±012）与其它三个证型两两比较均差异有统计学意义(P＜005)；（4）2小时存留率经方差分析比较发现，不同证型之间差异有统计学意义（P＜005）；湿热壅滞证（372%±128%）与肝胃气滞证（510%±147%）、肝胃郁热证（469%±116%）两两比较差异有统计学意义（P＜005），湿热壅滞证与脾虚气滞证两两比较无显著性差异。结论不同中医证型功能性消化不良具有不同的核素胃排空特点，湿热壅滞证呈胃排空加速表现，肝胃气滞证、脾虚气滞证呈胃排空延迟表现。
Abstract:
ObjectiveTo explore the characteristic of radionuclide gastric emptying on different TCM syndrome types in patients with functional dyspepsia. MethodsWe recruited 84 cases of muticenter with FD and divided into 4 groups: the stagnation of dampheat type, spleen deficiency and Qi stagnation type , Liver and stomach Qi stagnation type, and stagnated heat in liver and stomach type. All cases were conducted radionuclide gastric emptying test to collected gastric halfemptying time, emptying rate and 2 hour residual rate. Results (1) Gastric emptying time was delayed in 46 cases (54.8%) and normal in 38 cases (45.2%). (2) Gastric halfemptying time analysis: Liver Qi stagnation type (140.7 ± 55.3)min was longest, spleen deficiency and Qi stagnation type (134.3 ± 64.6)min and stagnation of dampheat type (118.7 ± 27.4)min. Stagnation of dampheat type (100.8 ± 26.7)min was shortest ,the analysis of variance test found that there:was significant difference among different types. (3) Gastric emptying rate was significant difference among different types through the analysis of variance test: stagnation of dampheat type (0.53 ± 0.12) was significantly faster than other types(P＜0.05), and there was no significant difference between the other types (P＞0.05). (4) 2 hour retention rate was significant difference among different types through the analysis of variance test: Stagnation of dampheat type (37.2% ± 12.8%)was significant lower than Liver and stomach Qi stagnation type (51% ± 14.7%) and stagnation of liver and stomach heat type (46.9% ± 11.6%), and there was no significant difference between stagnation of dampheat type and spleen deficiency and Qi stagnation type (P＞0.05) . ConclusionsDifferent TCM syndrome types had different characteristics of gastric emptying function in FD patients. Gastric emptying function was accelerated in stagnation of dampheat type , delayed in spleen deficiency and Qi stagnation type and Liver and stomach Qi stagnation type.

参考文献/References:

［1］Talley NJ, Verlinden M, Jones M. Can symptoms discriminate among those with delayed or normal gastric emptying indysmotilitylike dyspepsia? ［J］.Am J Gastroenterol, 2001,96: 14221428.
［2］Tack J，Talley N J，Camilleri M，et al．Functional gastroduodenal disorders［J］.Gastroenterology，2006，130(5)：419466.
［3］中华医学会消化病学分会胃肠动力组.中国消化不良的诊治指南（2007大连）［J］.胃肠病学，2008，13(2)：114117.
［4］中国中西医结合学会消化系统疾病专业委员会.功能性消化不良的中西医结合诊疗共识意见（2010）［J］.中国中西医结合杂志，2011，31（11）：15451549.
［5］翟宏丽．胃动力检测方法的研究新进展［J］.胃肠病学和肝病学杂志，2004，13(2)：207208．
［6］Hermansson G. Sivertsson gender related differences in gastric emptying rate of solid meals［J］.Dig Dis Sci,1996,41(10):19941998.
［7］Frederick L, Data, Paul et al, GenderRelated Differences in Gastric Emptying［J］.The Journal of NudearMedicine,1987,28:12041207.
［8］Kusano M，Zai H，shimoyama Y，et al. Rapid gstric emptying,rather than delayed gastric emptying,might provoke functional dyspepsia［J］.J Gastroenterol Hepatol，2011，26(3):7578.
［9］宋志强，柯美云，王智凤，等.不同分型功能性消化不良患者病理生理机制的比较研究［J］.中华消化杂志，2010，30（10）：729732.
［1０］陈鹏，王春松，孔令斌.胃动素与功能性消化不良研究进展［J］.中国实用医药，2008，3(10):187189.
［1１］Fraser RJ，Horowitz M，Maddox AF，et al. Hyperglycaemia slows gastric emptying in type 1 (insulindependent) diabetes mellitus［J］.Diabetologia, 1990，33: 675680.

相似文献/References:

[1]邓娜,蔺晓源,蔡光先,等.功能性消化不良中医证型动物模型的研究概况[J].环球中医药,2013,6(02):140.
　DENG Na,LIN Xiao yuan,CAI Guang xian..Research survey of the functional dyspepsia TCM animal models[J].,2013,6(05):140.
[2]刘晶,李峰,唐旭东,等.功能性消化不良动物模型及其在中医研究中的应用概述[J].环球中医药,2013,6(12):955.
　LIU Jing,LI Feng,TANG Xu dong,et al.Overview of functional dyspepsia animal model and its application in TCM research[J].,2013,6(05):955.
[3]沈淑华,吕宾,王坤根,等.功能性消化不良西医分型与中医证型的相关性研究[J].环球中医药,2012,5(01):33.
[4]郑洪光,石燕萍,李秀兰,等.健脾理气治疗功能性消化不良60例[J].环球中医药,2012,5(08):621.
[5]许卫华 王微 吕冉等.加味三香汤治疗肝郁脾虚型功能性消化不良的临床观察[J].环球中医药,2014,7(06):437.
　XU Wei hua,WANG Wei,LYU Ran,et al.Clinical study of Jiawei Sanxiang decoction treatment on patients with functional dyspepsia of liver stagnancy and spleen deficiency type[J].,2014,7(05):437.
[6]李欣航,陶晓雁,朱光昭,等.针灸功能性消化不良的配穴现状[J].环球中医药,2016,9(05):627.[doi:10.3969/j.issn.1674-1749.2016.05.031]
　LI Xin-hang,TAO Xiao-yan,ZHU Guang-zhao,et al.Acupoint combination status of acupuncture and moxibustion on functional dyspepsia[J].,2016,9(05):627.[doi:10.3969/j.issn.1674-1749.2016.05.031]
[7]石杨 常婧舒.李秋贵运用半夏泻心汤临床经验总结[J].环球中医药,2016,9(07):822.[doi:10.3969/j.issn.1674-1749.2016.07.015]

备注/Memo

备注/Memo:
基金项目：国家“十一五”科技支撑计划（2007BAI20B0901）
作者简介：许卫华（1977- ），女，2010级在读博士研究生，主治医师。研究方向：中西医结合治疗消化系统疾病。Email: xuwihua10@163.com
通讯作者：姚树坤（1957- ），医学博士，主任医师，教授，博士生导师。中国中西医结合学会常务理事，中国中西医结合学会消化病学会常委、肝病学会委员，中国医师协会消化医师分会执行常委、中西医结合医师分会常委，中华中医药学会感染病专业委员会副主任委员，北京市中西医结合学会肝病专业委员会主任委员。研究方向：中西医结合消化内科。Email: yaoshukun6@yahoo.com.cn
更新日期/Last Update: 2013-05-31