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[1]秦灵灵 王磊 李娟娥 刘铜华.仙鹤草对2型糖尿病大鼠胰岛素抵抗及炎性因子 的干预作用[J].环球中医药,2013,6(05):333-336.
　QIN Ling ling,WANG Lei,LI Juan e,et al.Effects of Herba Agrimoniae on insulin resisitance and inflammatory factors in T2DM rats[J].,2013,6(05):333-336.
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仙鹤草对2型糖尿病大鼠胰岛素抵抗及炎性因子 的干预作用()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第6卷
期数:
2013年05期
页码:
333-336
栏目:
论著
出版日期:
2013-05-06

文章信息/Info

Title:
Effects of Herba Agrimoniae on insulin resisitance and inflammatory factors in T2DM rats
作者:
秦灵灵 王磊 李娟娥 刘铜华
作者单位：100078北京中医药大学东方医院内分泌科［秦灵灵（博士研究生）、李娟娥］，科技处(刘铜华)；北京中医药大学第三附属医院内分泌科(王磊)
Author(s):
QIN Lingling;  WANG Lei;  LI Juane;  et al.
Department of endocrinology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
Corresponding author: LIU Tonghua, Email: thliu@vip.163.com
关键词:
仙鹤草提取物; 2型糖尿病; 血糖; 血脂; 胰岛素抵抗; 炎性因子
Keywords:
Herba Agrimoniae; Type 2 diabetes; Glucose; Blood lipid; Insulin resistance; Inflammatory factors
分类号:
R5871
DOI:
-
文献标志码:
-
摘要:
目的观察仙鹤草提取物对2型糖尿病大鼠血糖、血脂、胰岛素抵抗及血清中炎性因子的影响。方法采用高脂饲料喂养加腹腔注射小剂量链脲佐菌素STZ的方法制备2型糖尿病动物模型，随机分为4组(n=9)：模型组、吡格列酮组、仙鹤草高剂量组、仙鹤草低剂量组。灌胃给药4周后取血检测各组大鼠空腹血糖(FBG)、甘油三酯（TG）、总胆固醇(CHOL)、高密度脂蛋白(HDLC)、低密度脂蛋白(LDLC)，采用放射免疫法测定空腹血清胰岛素(Fins)、肿瘤坏死因子α(TNFα)、C反应蛋白(CRP)，并根据Fins,FBG计算胰岛素抵抗指数(HOMAIR)。结果仙鹤草高剂量可显著降低大鼠FBG,FINS,HOMAIR；可降低甘油三酯，升高高密度脂蛋白；降低血清中炎性因子TNFα和CRP含量。结论仙鹤草提取物对2型糖尿病大鼠具有降糖调脂的治疗作用，可缓解2型糖尿病胰岛素抵抗，并推测可能与降低血清炎性因子含量有关。
Abstract:
ObjectiveTo investigate the effects of Herba Agrimoniae on glucose and blood lipid, insulin resistance and the levels of inflammatory factors in T2DM Rats. MethodsThe T2DM rats induced by high lipid diet and small dosage intraperitonealinjection of STZ, were randomly divided into four groups(n=9 in each). Model, Herba Agrimoniae (high dose and low dose) and Pioglitazone were administered respectively by gavage. Four weeks later, the levels of FBG and blood lipid were detected. Fins were measured by radioactive immunoassay and accordingly insulin resistance indexes(HOMAIR) were figured out. TNFα and CRP in the serum were detected by the method of radioactive immunoassay too. ResultsCompared with model group, the levels of FBG, Fins, HOMAIR ,TG, were decreased, HDL was increased. The levels of TNFα, CRP in the serum were downregulated in high dose Herba Agrimoniae group. ConclusionsHerba Agrimoniae can decrease glucose,blood lipid and improve insulin resistance in type 2 diabetic mellitus rats by decreasing the the levels of inflammatory factors of TNFα and CRP.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：国家国际科技合作项目(2010DFB33260)
作者简介：秦灵灵(1984- )，女，2010级在读博士研究生。研究方向：中医药防治糖尿病作用机制研究。Email:15201484725@126.com
通讯作者：刘铜华(1963- )，医学博士，教授。研究方向：中医药防治糖尿病及其并发症临床及作用机制研究。Email:thliu@vip.163.com
更新日期/Last Update: 2013-05-31