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[1]安静,杨晋翔,来要良,等.辛开苦降法治疗慢性萎缩性胃炎临床疗效的荟萃分析[J].环球中医药,2013,6(07):505-0.
　AN Jing,YANG Jin xiang,LAI Yao liang,et al.Metaanalysis on effect of chronic atrophic gastritis treated with Chinese herbal medicine based on the method of acrid opening and bitter descending[J].,2013,6(07):505-0.
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辛开苦降法治疗慢性萎缩性胃炎临床疗效的荟萃分析()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第6卷
期数:
2013年07期
页码:
505-0
栏目:
论著
出版日期:
2013-07-06

文章信息/Info

Title:
Metaanalysis on effect of chronic atrophic gastritis treated with Chinese herbal medicine based on the method of acrid opening and bitter descending
作者:
安静;杨晋翔;来要良;刘永;
Author(s):
AN Jing; YANG Jinxiang; LAI Yaoliang; et al.
the Third Affiliated Hospital of Beijing University of Chinese Medicine，Beijing 100050，China
关键词:
中药治疗; 慢性萎缩性胃炎; 辛开苦降法; Meta分析; 循证医学
Keywords:
Treatment with Chinese herbal medicine; Chronic atrophic gastritis; Acid opening and bitter descending; Metaanalysis; Evidencebased medicine
分类号:
R5733+2
DOI:
-
文献标志码:
A
摘要:
目的比较以辛开苦降立法之中药组方与单纯西药治疗慢性萎缩性胃炎的临床疗效。方法通过制定随机对照高敏感性检索策略和对国内主要数据库检索(不考虑盲法,语言为中文和英文),两名评价人员分别根据纳入标准和剔除排除标准对检索的随机对照试验进行3次独立筛选和对所纳入研究进行有效的数据提取,并分别对文献质量进行科学评价,最终经核对一致的数据进行统计合并,根据异质性分析选用固定效应模式或随机效应模式进行系统分析。结果共4篇267例随机对照实验纳入研究,辛开苦降法的总有效[RR=1.31,95%CI(1.08,1.59),P=0.006],愈显率[RR=3.13,95%CI(1.78,5.50),P=0.096],其中3项研究数据纳入幽门螺旋杆菌(Hp)根除情况[RR=2.07,95%CI(0.74,5.83),P=0.17]。结论Meta分析显示符合辛开苦降立法的中药组方在临床疗效上优于单纯西药治疗,而Hp根除状况上尚不能认为优于单纯西药治疗;由于所纳入研究较少且部分研究为低质量偏倚风险不确定的随机对照研究,需高质量和低偏倚风险的研究进一步证实。
Abstract:
ObjectiveTo explore the effect of Chronic Atrophic Gastritis (CAG) treated between Chinese Herbal Medicine based on the method of acrid opening and bitter descending and purely western medicine. MethodsAfter searching only randomized clinical trials comparing the purely Western Medicine between Chinese Herbal Medicine based on acrid opening and bitter descending with using hypersensibility specific strategy (irrespective of blinding, searching with English and Chinese), two authors independently identified the trials for exclusion and inclusion criterion after screening duplicate and irrelevant copies and reading article title and abstract and full text, and extracted the data and assessed the methodological quality of the trials and risk of bias. After calculating the Relative Risk (RR) and 95% confidence intervals（CI）, Metaanalysis was performed by RevMan 50 with fixed effects models or random effects models. Results4 RCTs with 267 patients were included this review. There was statistically significant between two groups on overall effect ［RR=131，95% CI（112, 154）］ and curative effect［RR=217，95％CI（149，314）,P=00001］.There was no significant difference between two groups in eradicating HP［RR=153，95％CI（088，265）,P=013］. Conclusion The therapeutic effect of Chinese Herbal Medicine intervention of PLGC was thought to be significant over using the purely Western Medicine, but further randomized trials with highquality and lowrisked bias is needed.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81173293）；国家中医药管理局重点研究室第一批建设项目
作者单位：100029 北京中医药大学第三附属医院［安静（博士研究生）］，消化科(杨晋翔)；北京宣武中医医院消化科（来要良、刘永）
作者简介：安静（1982- ），女，2011级在读博士研究生。研究方向：脾胃病的中医药防治研究。Email： anjing1618@sina.com
通讯作者：杨晋翔（1957- ），硕士，主任医师，教授。研究方向：脾胃肝胆病的中医临床及实验研究。Email：yjx571102@163.com
更新日期/Last Update: 1900-01-01