|本期目录/Table of Contents|

[1]安艳辉,商建伟,闫博,等.补中益气汤对精索静脉曲张大鼠睾丸生精功能和一氧化氮的影响[J].环球中医药,2013,6(08):566-0.
 AN Yan hui,SHANG Jian wei,YAN Bo,et al.Effects of Buzhong Yiqi Decoction on experimental varicocele testicular sperm production function and abdominal aorta of rats serum NO content[J].,2013,6(08):566-0.
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补中益气汤对精索静脉曲张大鼠睾丸生精功能和一氧化氮的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第6卷
期数:
2013年08期
页码:
566-0
栏目:
论著
出版日期:
2013-08-06

文章信息/Info

Title:
Effects of Buzhong Yiqi Decoction on experimental varicocele testicular sperm production function and abdominal aorta of rats serum NO content
作者:
安艳辉;商建伟;闫博;王旭昀;李铁;张耀圣;
Author(s):
AN Yanhui SHANG Jianwei YAN Boet al.
Department of andrology,Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine,Beijing 100700,China
关键词:
精索静脉曲张一氧化氮生精功能睾丸补中益气汤
Keywords:
VaricoceleNitric oxideSperm production functionTestesBuzhong Yiqi Decoction
分类号:
R2855
DOI:
-
文献标志码:
A
摘要:
目的探讨补中益气汤对精索静脉曲张大鼠睾丸生精功能和腹主动脉血中一氧化氮(nitricoxide,NO)的影响。方法将30只SD成年雄性大鼠,按随机数字表法分为正常组、模型组和治疗组,共3组,每组10只。各组均在建立实验性精索静脉曲张大鼠模型7天后开始治疗,连续用药45天。实验结束后,抽取腹主动脉血,分离血清,检测血清NO;获取睾丸组织,做病理切片;处死大鼠。结果与正常组相比,模型组和组治疗组中左右两侧睾丸组织均出现病理性改变;与正常组相比,模型组和治疗组中NO含量显著升高(P<0.05),但模型组与治疗组相比NO含量无显著性差异(P>0.05)。结论补中益气汤颗粒剂能够能够减轻精索静脉曲张大鼠睾丸生精功能的损害,但不能降低腹主动脉血中NO的含量。
Abstract:
ObjectiveTo investigate the effect of Buzhong Yiqi Decoction on experimental varicocele testicular sperm production function and abdominal aorta of rats serum NO content. Methods30 SD adult male rates, were randomly divided into normal group, model group, treatment group, with 10 rats in each group, a total of three groups, all the rats in the days after of treatment,45 days of continuous. After the end of the experiment, extraction of abdominal aorta blood, separation of serum, obtaining testicular tissue, put to death in the rat, testicular pathological slices, detection of serum NO. Results Compared with normal group, model group and treatment group in the left and right sides of the testicular tissue in pathological change; Compared with normal group, model group and the NO content in the treatment group was significantly increased (P<005), but in model group and treatment group compared with NO content there was NO significant difference (P>005). ConclusionBuzhong Yiqi Decoction can reduce varicocele rat testicular sperm production function damage, but cannot reduce abdominal aorta content of NO in blood.

参考文献/References:

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[8]刘蕾,王淑秋,赵玉珍,等.实验性精索静脉曲张大鼠睾丸组织TNFα和NO含量的变化[J].中国病理生理杂志,2005,21(10):20542056.
[9]孙自学,蒋平,王春霞.益肾通络颗粒对实验性精索静脉曲张大鼠睾丸组织SOD、MDA、NO、ATP的影响[J].中国中医基础医学杂志,2008,14(9):661.

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备注/Memo

备注/Memo:
基金项目:北京中医药大学校级课题(2011JYB22XS001)
作者单位:100029 北京中医药大学东直门医院男科[安艳辉(硕士研究生)、商建伟、闫博(硕士研究生)、张耀圣];北京潞河医院中医科(王旭昀);北京房山良乡第一医院急诊科(李铁)
作者简介:安艳辉(1985- ),2010级在读硕士研究生。研究方向:中医男科疾病治疗。Email:anyanhui2008_@126.com
通讯作者: 张耀圣(1965- ),博士,主任医师,硕士生导师。中华中医药学会外科分会副秘书长,北京中西医结合学会青年委员,中华创伤学会组织修复专业委员,中华中医药学会亚健康分会委员。研究方向:中医男科疾病治疗。Email:ysz3129@163.com
更新日期/Last Update: 1900-01-01