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[1]张永超,黄世敬.芍药抗抑郁作用机制探析[J].环球中医药,2013,6(10):795-0.
　ZHANG Yong chao,HUANG Shi jing..Mechanism analysis for the antidepressant effect of Peony[J].,2013,6(10):795-0.
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芍药抗抑郁作用机制探析()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第6卷
期数:
2013年10期
页码:
795-0
栏目:
综述
出版日期:
2013-10-06

文章信息/Info

Title:
Mechanism analysis for the antidepressant effect of Peony
作者:
张永超;黄世敬;
Author(s):
ZHANG Yongchao;  HUANG Shijing.
Traditional Chinese medicine R & D Center，Guanganmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053，China
关键词:
芍药; 白芍总苷; 赤芍总苷; 抗抑郁作用
Keywords:
Peony; Total glucosides of paeony; Total saponins of paeonia; Antidepression effect
分类号:
R2777
DOI:
-
文献标志码:
A
摘要:
本文旨在探讨芍药抗抑郁作用的可能机制。通过检索近十年来相关文献研究发现,白芍的有效成分白芍总苷及赤芍的有效成分赤芍总苷对于抑郁症的治疗有一定疗效,其可能机制包括提高单胺类神经递质含量、调节下丘脑—垂体—肾上腺轴的功能异常、修复受损神经元、抑制单胺氧化酶表达、增强神经保护作用等多个方面。白芍—柴胡、赤芍—淫羊藿、赤芍—石菖蒲等药对配伍方法能够促进芍药的抗抑郁作用,但针对芍药其他组成成分和赤白芍作用差别的研究尚匮乏。因此,芍药作为临床常用抗抑郁治疗药物,具备一定的科学依据,但还需要进一步探索。
Abstract:
This paper aims to explore possible mechanisms of antidepressant effect of peony. By searching literatures in last decade, the authors found that the possible mechanisms of peony include several aspects such as improving the single amine neurotransmitter content, adjusting HPA axis dysfunction, repairing damaged neurons, restraining the expression of monoamine oxidase and enhancing nerve protective effect. The coupled drug combination of paeonia radix alba and bupleuriradix, paeoniae radix rubra and epimedii folium, paeoniae radix rubra and acori tatarinowii rhizoma could promote the antidepressant effects. However, the research about other components of peony and the difference between paeonia radix alba and radix paeoniae rubra are scarce. Therefore, it has a certain scientific basis to use peony as the clinical commonly used antidepressant medicine, but it still needs further exploration.

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相似文献/References:

备注/Memo

备注/Memo:

作者单位：100053 北京，中国中医科学院广安门医院中药研发中心［张永超（硕士研究生）、黄世敬］
作者简介：张永超(1988- )，2011级在读硕士研究生。研究方向：中医内科学。Email:zyc9958@163.com
通讯作者：黄世敬（1964- ），博士，研究员。研究方向：中医脑病临床与基础。Email:gamhsj@126.com
更新日期/Last Update: 1900-01-01