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[1]陈梅卿,赖畅钦,李卫华,等.人参皂苷Rb_1对自发性高血压大鼠氧化应激指标的影响[J].环球中医药,2013,6(11):811-0.
　CHEN Mei qing,LAI Chang qin,LI Wei hua,et al.Phamacological effect of ginsenoside Rb1 on oxidative stress indicators of spontaneously hypertensive rats[J].,2013,6(11):811-0.
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人参皂苷Rb_1对自发性高血压大鼠氧化应激指标的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第6卷
期数:
2013年11期
页码:
811-0
栏目:
论著
出版日期:
2013-11-06

文章信息/Info

Title:
Phamacological effect of ginsenoside Rb1 on oxidative stress indicators of spontaneously hypertensive rats
作者:
陈梅卿;赖畅钦;李卫华;石桂秀;李燕;黄峥嵘;
Author(s):
CHEN Meiqing; LAI Changqin; LI Weihua; et al
Department of Rheumatology，the first Hospital Affiliated to Xiamen University,Xiamen 361000，China
关键词:
人参皂苷Rb1; 自发性高血压大鼠; 氧化应激指标
Keywords:
Ginsenoside Rb1; Spontaneously Hypertension Rat; Oxidative stress indicators
分类号:
R2855
DOI:
-
文献标志码:
A
摘要:
目的观察人参皂苷Rb1对自发性高血压大鼠(SHR)血压及氧化应激指标的影响。方法选择12周龄雄性SHR36只,随机分为4组,人参皂苷Rb1大剂量和小剂量组、空白组(生理盐水)、阳性对照组(氨氯地平)。血压正常的京都WistarKyoto(WKY)大鼠9只为正常对照组。于治疗第0周、12周分别用尾袖法测定大鼠动脉收缩压,并分别采血,检测超氧化物歧化酶(SOD)、丙二醛(MDA)及氧化低密度脂蛋白(ox-LDL)等指标。结果人参皂苷Rb1作用12周后,大、小剂量组血压均较治疗前明显下降,但较氨氯地平组差;Rb1高剂量组及氨氯地平组分别与生理盐水对照组比,差别均有统计学意义(P<0.05)。针对氧化应激指标的检测发现,人参皂苷Rb1作用后,MDA,SOD以及ox-LDL水平都有一定程度的改善,尤其以MDA和oxLDL改变最为显著,与生理盐水组比,差别具有统计学意义(P<0.05)。结论人参皂苷Rb1具有较为显著的抗氧化作用,其降血压效应部分与其对抗氧化应激作用有关。
Abstract:
ObjectiveTo observe the pharmacological effect of ginsenoside Rb1 on blood pressure and oxidative stress indicators in spontaneously hypertension rats. Methods36 12weekold male SHRs were randomly divided into four groups:large doses of ginsenoside Rb1 and small dose group and blank group (saline), positive control group (amlodipine) 9 normotensive Wistar Kyoto rats (WKY) only for the normal control group A tail cuff method was carried out to determine the arterial blood pressure at the treatment of 0 week and the end of 12 weeks respectively Blood was also collected to analysis the indicators of oxidative stress such as SOD activity，MDA level and oxLDL at the same time ResultsAfter 12 weeks treatment with ginsenoside Rb1, the blood pressure of large and small dose groups were significantly decreased than pretreatment, but not superior to the amlodipine group；When Rb1 of high dose group and amlodipine group compared with the control group respectively, the difference was statistically significant（P＜005） Detection of oxidative stress index found，after Rb1 treatment, MDA, SOD and oxLDL levels all have a certain degree of improvement, especially for the MDA and oxLDL changed most significantly, compared with the saline group，the difference was statistically significant（P＜005）. ConclusionGinsenoside Rb1 has significant antioxidant activity, the blood pressure lowering effectsassociated with againsting oxidative stress to some extent.

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备注/Memo

备注/Memo:

作者单位：361000厦门大学附属第一医院风湿免疫科（陈梅卿、石桂秀、李燕），中医科（赖畅钦），心内科（李卫华、黄峥嵘）；福建医科大学第一临床医学院［陈梅卿（在职硕士研究生）、李卫华］
作者简介：陈梅卿（1970- ），女，本科，副主任医师。研究方向：高血压病的免疫学发病机制。Email:chenmq6699@163com
通讯作者：李卫华（1962- ），硕士，教授，主任医师，硕士生导师。研究方向：冠脉疾病炎症因子研究。Email: liweihua@medmail.comcn；石桂秀（1963- ），博士，教授，主任医师，博士生导师。研究方向：免疫调控和自身免疫研究。Email:guixiushi@gmailcom。李卫华与石桂秀并列为本文通讯作者
更新日期/Last Update: 1900-01-01