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[1]刘丛丛,王扬,莫倩,等.电针次髎/中髎穴抑制膀胱过度活动的穴位特异性研究[J].环球中医药,2013,6(12):885-0.
　LIU Cong cong,WANG Yang,MO Qian,et al.Electroacupuncture at BL32/BL33 in the inhibition of overactive bladder and its acupoints specificity[J].,2013,6(12):885-0.
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电针次髎/中髎穴抑制膀胱过度活动的穴位特异性研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第6卷
期数:
2013年12期
页码:
885-0
栏目:
论著
出版日期:
2013-12-06

文章信息/Info

Title:
Electroacupuncture at BL32/BL33 in the inhibition of overactive bladder and its acupoints specificity
作者:
刘丛丛;王扬;莫倩;王伟明;刘志顺;
Author(s):
LIU Congcong;  WANG Yang;  MO Qian; et al.
Acupuncture Department, Guanganmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
关键词:
次髎; 中髎; 膀胱过度活动症; 穴位特异性
Keywords:
Ciliao (BL32); Zhongliao (BL33); Overactive bladder; Acupoints specificity
分类号:
R2242
DOI:
-
文献标志码:
A
摘要:
目的探讨次髎和中髎穴抑制膀胱过度活动的穴位特异性。方法60只SD大鼠随机分为模型组和5个电针组:次髎/中髎组、委中组、三阴交组、通天组、合谷组,每组10只。各组大鼠均先采用生理盐水进行膀胱灌注(基线Ⅰ),继以0.25%乙酸膀胱灌注建立大鼠膀胱过度活动模型(基线Ⅱ)。造模成功后,5个电针组进行电针治疗5分钟,模型组不予电针治疗。电针后再次以生理盐水进行膀胱灌注。观察灌注期间大鼠排尿间隔时间、膀胱排尿压力、膀胱基础压力和平均排尿压力的改变。结果与基线Ⅰ相比,基线Ⅱ时各组排尿间隔时间显著缩短(P<0.01)、膀胱排尿压力和平均排尿压力显著下降(P<0.01)。电针干预后,各组排尿间隔时间较基线Ⅱ均显著延长,仅次髎/中髎组与基线Ⅰ比较差异不显著,并且其增加值显著大于模型组(P<0.001)和其他电针组(P<0.01,或P<0.05)。次髎/中髎组电针后膀胱排尿压力较基线Ⅱ显著升高(P<0.05)、与基线Ⅰ差异不显著,并显著高于模型组(P<0.001)和其他电针组(P<0.05)。结论次髎、中髎可有效抑制膀胱过度活动,此抑制效应具有穴位特异性。
Abstract:
ObjectiveTo investigate the acupoints specificity of Ciliao (BL32) and Zhongliao (BL33) on inhibiting overactive activity of bladder. Methods60 SD rats were randomly divided into 1 model group and 5 electroacupuncture groups: Ciliao/Zhongliao (BL32/BL33) group, Weizhong (BL40) group, Hegu (LI4) group, Tongtian (BL7) group and Sanyinjiao (SP6) group. Rats in each group were performed with bladder perfusion with normal saline (basalⅠ, to get the normal data of rats) and 025% Acetic acid (basalⅡ, to make rat model of overactive bladder ), respectively. Rats in 5 electroacupuncture groups received elecltroacupuncture treatment 5 minutes, while rats in model group received no intervention. Rats in each group were performed with bladder perfusion with normal saline again. Changes of intercontraction interval (ICI), vesical micturition pressure (VMP), basal pressure and average voiding pressure in all groups were observed. ResultsCompared with basalⅠ, the ICI of each group was significantly shortened (P＜001) and the VMP significantly decreased (P＜001) at basalⅡ. After electroacupuncture treatment, the ICI were prolonged in all groups but also shorter than basalⅠexcept Ciliao/Zhongliao group, while the increased value of Ciliao/Zhongliao group significantly greater than model group (P＜0001) and other electroacupuncture groups(P＜001 or P＜005).The VMP of Ciliao/Zhongliao group was significantly increased (P＜005) compared with the model group (P＜0001) and other electroacupuncture groups (P＜005). ConclusionElectroacupuncture at Ciliao/Zhongliao point can inhibit bladder hyperactivity, which shows an effect of acupoints specificity.

参考文献/References:

［1］刘志顺,王扬,徐海蓉,等.电针治疗中风后急迫性尿失禁疗效观察［J］.新中医,2010,42(2):7375.
［2］邓春雷.调整膀胱机能的穴位特异性及其实质的探讨［J］.上海针灸杂志,1987,(3):17.
［3］Kokoro Hino, Hisashi Honjo, Masahiro Nakao, et al. The Effects of Sacral Acupuncture on Acetic Acidinduced Bladder Irritation in Conscious Rats［J］. Urology, 2010, 75(3): 730734.
［4］于金娜,刘志顺,马晓晶,等.大鼠“次髎/中髎”穴的定位和解剖结构［J］.针刺研究,2007,32(5):334.
［5］王金武,侯春林,卢宁,等.骶神经根对膀胱功能的选择性支配［J］.中国临床康复,2005,9(17):2279.
［6］李忠仁.实验针灸学［M］.北京:中国中医药出版社,2003:314330.
［7］Tetsuya Imamura, Osamu Ishizuka, Naoki Aizawa, et al. Goshajinkigan Reduces Transmitter Proteins and Sensory Receptors Associated with C Fiber Activation Induced by Acetic Acid in Rat Urinary Bladder［J］. Neurourology and Urodynamics. 2008,27(8):832837.
［8］De Wachter S, Wyndaele JJ. Intravesical oxybutynin: a local anesthetic effect on bladder C afferents［J］. J Urol. 2003,169(5):18921895.
［9］Mitobe M, Inoue H, Westfall TD, et a1. A new method for producing urinary bladder hyperactivity using a noninvasive transient intravesical infusion of acetic acid in conscious rats［J］. J Pharmacol Toxicol Methods, 2008, 57(3): 188193.
［1０］Mitsui T, Kakizaki H, Matsuura S, et al. Afferent fibers of the hypogastric nerves are involved in the facilitating effects of chemical bladder irritation in rats［J］. J Neurophysiol. 2001,86(5):22762284.
［1１］Herrera GM, Meredith AL. Diurnal variation in urodynamics of rat［J］. PLoS One. 2010,5(8):e12298.
［1２］Lee WC, Chiang PH, Tain YL, et al. Sensory Dysfunction of Bladder Mucosa and Bladder Oversensitivity in a Rat Model of Metabolic Syndrome［J］. PLoS One. 2012，7(9):e45578.
［1３］Zhang X, Igawa Y, Ishizuka O, et al. Effects of resiniferatoxin desensitization of capsaicinsensitive afferents on detrusor overactivity induced by intravesical capsaicin, acetic acid or ATP in conscious rats［J］. Naunyn Schmiedebergs Arch Pharmacol，2003,367(5):473479.
［1４］孙卫兵,杨帆,齐清会.电针次髎穴对膀胱过度活动症大鼠尿动力穴的影响［J］.大连医科大学学报,2012,34(2):115119.
［1５］Abrams P, Blaivas JG, Fowler CJ, et al. The role of neuromodulation in the management of urinary urge incontinence［J］. BJU Int, 2003,91(4):355359.
［1６］侯春林, 陈爱民, 张世民,等. 骶神经前根电刺激恢复脊髓损伤后的排尿功能［J］. 中华骨科杂志, 2003, 23(5): 313314.
［1７］Shaker H, Wang Y, Loung D, et al. Roel of Cafferent fibres in the mechanism of action of sacral nerve root neuromodulation in chronic spinal cord injury［J］. BJU Int, 2000,85(7): 905910.
［1８］Yu JN, Ma XJ, Liu ZS, et a1. Effect of electroacupuncture at “Ciliao”(BL 32) on cfos expression in the sacral segment of spinal cord in rats with detrusor hyperreflexia［J］. Zhen Ci Yan Jiu, 2010, 35(3): 204207.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金(81173353)
作者单位：100053 北京，中国中医研究院广安门医院针灸科［刘丛丛(博士研究生)、莫倩(博士研究生)、王伟明(博士研究生)、刘志顺］
作者简介：刘丛丛(1985 )，女，2011级在读博士研究生。研究方向：针灸治疗下泌尿道功能障碍和女性内分泌病变临床和基础。Email: xiongxiong106@126.com
通讯作者：刘志顺(1963 )，博士，博士生导师，主任医师。研究方向：针灸治疗下泌尿道功能障碍和女性内分泌病变临床和基础。Email: liuzhishun@aliyun.com
更新日期/Last Update: 1900-01-01