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[1]高玉峰,吴剑聪,耿楠,等.推拿对坐骨神经损伤大鼠运动功能和神经丝蛋白-M的影响[J].环球中医药,2013,6(12):894-0.
　GAO Yu feng,WU Jian cong,GENG Nan,et al.Effect of Tuina therapy on motor function and scaffolding proteins NFM in neurons of sciatic nerve injury rat models[J].,2013,6(12):894-0.
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推拿对坐骨神经损伤大鼠运动功能和神经丝蛋白-M的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第6卷
期数:
2013年12期
页码:
894-0
栏目:
论著
出版日期:
2013-12-06

文章信息/Info

Title:
Effect of Tuina therapy on motor function and scaffolding proteins NFM in neurons of sciatic nerve injury rat models
作者:
高玉峰;吴剑聪;耿楠;于天源;
Author(s):
GAO Yufeng; WU Jiancong; GENG Nan; et al
School of Acupuncturemoxibustion and Tuina, Beijing University of Chinese Medicine,Beijing 100029,China
关键词:
推拿; 坐骨神经损伤; 斜板实验; 神经丝蛋白-M
Keywords:
Tuina; Sciatic nerve injury; Oblique board test; NeurofilamentM
分类号:
R2441
DOI:
-
文献标志码:
A
摘要:
目的从坐骨神经损伤大鼠行为学和神经丝蛋白M(NF-M)的角度,探讨推拿治疗坐骨神经损伤的起效机制。方法采用夹持法建立坐骨神经损伤模型,将大鼠随机分为正常组、假手术组、模型组、模型对照组、推拿组,以按摩推拿手法模拟仪进行干预,通过斜板实验观察各组大鼠行为学变化;通过免疫组织化学染色观察各组大鼠L3
Abstract:
ObjectiveTo discuss the principal mechanisms for tuina therapy on Sciatic Nerve Injury from the viewpoint of behavioristics and scaffolding proteins NFM in neurons of Sciatic Nerve Injury rat models MethodsUse the clamping method to induce the sciatic nerve injury model And then to observe the behavioral changes by oblique board test and the expression of scaffolding proteins NFM in L3L5 spinal cord by immunohistochemical staining in normal group, shamoperated group, model group, model control group and Tuina group rats intervened with massage simulator ResultsInclined plate test scores of model group, model control group rats compared with that of the normal group were significantly lowerAfter being treated for 20 days (P＞005 ),compared with normal group there is no significant differences Model group, model control group and the massage groups immunohistochemical expressions of NFM compared with that of the normal group were significantly increased,and there is statistically significant difference between massage group and model group (P＜005 )ConclusionThe massage therapy promote the axoplasmic transport function, accelerate neuronal survival and ultimately improve the motor function of sciatic nerve injury model rats by the expression of scaffolding proteins NFM in spinal cord

参考文献/References:

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［3］Tom VJ,SandrowFeinberg HR,Miller K,et alCombining peripheral nerve grafts and chondroitinase promotes functional axonal regeneration in the chronically injured spinal cord［J］J Neurosis,2009,29(47):1488114890
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［5］赵秀兰,于丽华,谢克勤甲胺磷对母鸡坐骨神经中神经丝蛋白的影响［J］中华预防医学杂志,2005,39(3):171174
［6］王频，谢克勤2,5HD对大鼠DRG神经元神经丝蛋白表达的影响［J］病理学杂志，2008,22(4):275279.
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备注/Memo

备注/Memo:
基金项目：北京中医药大学自主课题（532/0100604213）
作者单位：100029北京中医药大学针灸推拿学院［高玉峰(博士研究生)、吴剑聪（博士研究生）、耿楠（硕士研究生）、于天源］
作者简介：高玉峰（1979- ），2011级在读博士研究生。研究方向：针灸推拿治疗周围神经损伤机理研究。Email：nmgaoyufeng@163com
通讯作者：于天源（1966- ），教授，主任医师，博士生导师，研究方向：针灸推拿治疗周围神经损伤机理研究。Email：yutianyuan@sinacom
更新日期/Last Update: 1900-01-01