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[1]周鑫,赵进喜,王世东,等.基于广义估计方程的益气通络方治疗早期糖尿病肾脏病临床疗效评价研究[J].环球中医药,2013,6(12):898-0.
　ZHOU Xin,ZHAO Jin xi,WANG Shi dong,et al.Study on clinical efficacy of Yiqi Tongluo Decoction in patients with early diabetic kidney disease based on generalized estimating equations[J].,2013,6(12):898-0.
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基于广义估计方程的益气通络方治疗早期糖尿病肾脏病临床疗效评价研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第6卷
期数:
2013年12期
页码:
898-0
栏目:
论著
出版日期:
2013-12-06

文章信息/Info

Title:
Study on clinical efficacy of Yiqi Tongluo Decoction in patients with early diabetic kidney disease based on generalized estimating equations
作者:
周鑫;赵进喜;王世东;柯雅思;傅强;宫晴;吴圣贤;
Author(s):
ZHOU Xin;  ZHAO Jinxi;  WANG Shidong;  et al.
Department of nephrology & endocrinology, Beijing University of Chinese Medicine, Beijing 100700, China
关键词:
益气通络方; 糖尿病肾脏病; 临床疗效; 广义估计方程
Keywords:
Yiqi Tongluo Decoction; Diabetic kidney disease; Curative effect; Generalized estimating equations
分类号:
R2554
DOI:
-
文献标志码:
A
摘要:
目的运用广义估计方程评价益气通络方对早期糖尿病肾脏病患者的临床疗效。方法采用随机对照的方法将符合纳入标准的57例患者随机分为A组28例、B组29例,两组患者均给予基础治疗,A组给予益气通络方;B组给予厄贝沙坦片,进行12周随访观察,记录患者中医证候评分及24小时尿微量白蛋白排泄率等指标,采用广义估计方程对相关指标进行统计分析。结果与治疗前相比,A组和B组24小时尿微量白蛋白排泄率显著降低(P<0.05);A组中医证候积分较B组显著降低(P<0.05)。结论运用广义估计方程分析重复测量数据可靠、可行,益气通络方可有效降低早期糖尿病肾脏病患者24小时尿微量白蛋白排泄率、证候积分水平,且用药越久疗效越好,对早期糖尿病肾脏病有理想的防治作用。
Abstract:
ObjectiveTo observe the clinical efficacy of Yiqi Tongluo Decoction in patients with early diabetic kidney disease by using generalized estimating equations MethodsRandomizedcontrolled design was carried out The selected 57 DN patients were randomized into group A of 28 cases and group B of 29 cases On the basis of foundation treatment, patients in group A received Yiqi Tongluo Decoction while patients in group B were given Irbersartan oral treatment, with followup observatron for 12 weeks The total score of TCM syndrome and 24hour urinary albumin excretion rate were analyzed with generalized estimating equations methods ResultsComparing with those before treatment, 24hour urinary albumin excretion rate was significantly reduced in both group A and group B(P＜005) The total score of TCM syndrome of group A significantly lower than group B(P＜005) ConclusionGeneralized estimating equations is reliable and feasible analyzing repeated data Yiqi Tongluo Decoction can effectively reduce the 24hour urinary albumin excretion rate and symptom integral level in patients with early diabetic kidney disease, and the longer the prescription is being used the better treatment we can achieve which demonstrate ideal effects on the prevention and treatment of early diabetic kidney disease

参考文献/References:

［1］王海燕肾脏病学［M］3版.北京：人民卫生出版社，2008：14241426
［2］Yang W, Lu J, Weng J, et al Prevalence of diabetes among men and women in China［J］ The New England Journal of Medicine, 2010,362(12):10901101
［3］牟新,姜淼,宋美铃,等 赵进喜教授治疗糖尿病肾病经验介绍［J］新中医,2005,37(11):1718
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［5］夏彦,潘晓平,刘元元,等 广义估计方程在临床试验重复测量资料中的应用［J］现代预防医学,2005,32(5):444445
［6］王永炎,常富业,杨宝琴病络与络病对比研究［J］北京中医药大学学报,2005,28(3):16
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相似文献/References:

[1]吴文静 赵进喜 王世东 韩梅 刘鑫源 张向伟 何沐 李书婕.糖尿病肾脏病气虚血瘀证证候诊断量表的信度和效度分析[J].环球中医药,2016,9(08):936.[doi:10.3969/j.issn.1674-1749.2016.08.008]
　WU Wen-jing,ZHAO Jin-xi,WANG Shi-dong,et al.Analysis of reliability and validity of the diagnostic scale for diabetes kidney disease with qi deficiency and blood stasis syndrome[J].,2016,9(12):936.[doi:10.3969/j.issn.1674-1749.2016.08.008]

备注/Memo

备注/Memo:

作者单位：100700 北京中医药大学东直门医院肾病内分泌科［周鑫（博士研究生）、赵进喜、王世东、傅强、宫晴］，神经内科（吴圣贤）；福建省泉州市中医院肾病科（柯雅思）
作者简介：周鑫（1986 ），女，2011级在读博士研究生。研究方向：中医药防治糖尿病及其并发症。Email：bj977@163com
通讯作者：赵进喜（1965 ），博士，主任医师，博士生导师，教授。国家中医药管理局中医内科内分泌重点学科带头人，世界中医药学会联合会糖尿病专业委员会秘书长及副会长，中华中医药学会糖尿病分会副主委，北京中医药学会糖尿病专业委员会副主委，北京医学会内分泌专业委员会委员。研究方向：中医药防治糖尿病及其并发症。Email：zhaojinximd@126com
更新日期/Last Update: 1900-01-01