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[1]陈宁 叶丽红.芹菜素抑制肿瘤细胞增殖机制研究进展[J].环球中医药,2014,7(02):151-0.
　CHEN Ning,YE Li hong..Mechanism of apigenins inhibition of cancer cell proliferation : Review of Progress[J].,2014,7(02):151-0.
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芹菜素抑制肿瘤细胞增殖机制研究进展()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第7卷
期数:
2014年02期
页码:
151-0
栏目:
综述
出版日期:
2014-02-06

文章信息/Info

Title:
Mechanism of apigenins inhibition of cancer cell proliferation : Review of Progress
作者:
陈宁 叶丽红
Author(s):
CHEN Ning; YE Lihong.
Nanjing university of traditional Chinese medicine， Nanjing 210046, China
关键词:
芹菜素; 癌细胞; 抑制增殖; 机制
Keywords:
Apigenin; Cancer cells;  Inhibition of proliferation;  Mechanism
分类号:
R2855
DOI:
-
文献标志码:
A
摘要:
本文通过参考近年来对芹菜素抑制肿瘤细胞增殖作用的研究的相关文献，于芹菜素对肿瘤细胞的增殖抑制作用机制做了归纳和探讨。研究发现，芹菜素对多种癌细胞都有抑制其生长和促使其凋亡的作用，其对各种癌细胞作用的机理研究已经深入到细胞和分子水平，包括对细胞凋亡和周期相关基因的调控，对细胞周期G0/G1,S及G2/M期的阻滞，对与凋亡相关的线粒体途径和非线粒体途径的各种酶和蛋白表达的影响，抑制肿瘤细胞血管生成以及增强肿瘤细胞对化疗药物的敏感性等。芹菜素抑制肿瘤细胞增殖机理值得我们深入探索，其作为一种自然界广泛存在的抗癌症化合物具有广阔的应用前景。
Abstract:
In this paper, the mechanism of apigenins inhibition of cancer cell proliferation was summarized and discussed with the reference of relevant literatures of inhibition in recent years. The research showed that apigenin had the effects of inhibition of proliferation and cell apotosis induction on various kinds of cancer cells and the mechanism was further concentrated on the cellular and molecular levels such as regulating cell gene related to cell cycle and apotosis，blocking cell cycle of G0/G1,S and G2/M stage，influencing the expression of protein and kidney related to mitochondrial or nonmitochondrial control of apotosis, inhibiting tumor angiogenesis and increasing the sensitivity of tumor cells to chemotherapy drugs. The mechanism of apigenins inhibition of cancer cell proliferation is worth our further exploration. Apigenin has broad application prospects as an anticancer compound widely distributed in nature.

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备注/Memo

备注/Memo:
基金项目：科技部“十一五”国家科技支撑计划( 2006BAI11B0801)；江苏省高校优势学科建设工程资助项目(PAPD)
作者单位：210046 ，南京中医药大学第一临床医学院［陈宁（硕士研究生）、叶丽红］作者简介：陈宁（1989-），女，2007级七年制在读硕士研究生。研究方向：中医学（中西医结合肿瘤内科）。Email：835569624@qq.com通讯作者：叶丽红(1967-)，女，博士，教授，主任医师，硕士研究生导师。研究方向：内科杂病及肿瘤的中医药防治。Email: cocolihongye@126.com
更新日期/Last Update: 1900-01-01