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[1]郭云霞 李绍旦 杨明会.补肾活血颗粒治疗帕金森病抑郁临床研究[J].环球中医药,2014,7(04):275-0.
　GUO Yun xia,LI Shao dan,YANG Ming hui,et al.Bushen Huoxue Granule(BSHXG) for clinical studies of Parkinsons disease with depression[J].,2014,7(04):275-0.
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补肾活血颗粒治疗帕金森病抑郁临床研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第7卷
期数:
2014年04期
页码:
275-0
栏目:
论著
出版日期:
2014-04-06

文章信息/Info

Title:
Bushen Huoxue Granule(BSHXG) for clinical studies of Parkinsons disease with depression
作者:
郭云霞 李绍旦 杨明会
Author(s):
GUO Yunxia;  LI Shaodan;  YANG Minghui;  et al.
Department of Taditional Chinese Medicine , PLA General Hospital, Beijing 100853, China
关键词:
补肾活血:6616; 帕金森病:5629; 临床研究:3671; 颗粒:2127; 治疗:1830; 抑郁:1777
Keywords:
Parkinsons disease with depression PDD; Bushen Huoxue Granule; Hamilton depression scale (HAMD ); Unified Parkinsons disease rating scale( UPDRS )
分类号:
R2777
DOI:
-
文献标志码:
A
摘要:
目的观察补肾活血颗粒治疗帕金森病抑郁的临床疗效。方法采用随机、双盲、对照试验方案，将65例帕金森病抑郁患者随机分为治疗组（补肾活血颗粒组）35例和对照组30例，治疗组服用补肾活血颗粒加西药多巴丝肼片，对照组服用中药安慰剂加西药多巴丝肼片。疗程为6个月。观察治疗第3、6月时2两组汉密顿抑郁量表（HAMD）及帕金森病评定量表 ( UPDRS )积分变化。结果两组HAMD评分在治疗3个月时与治疗前比均无统计学意义(P>005)、治疗组（1422±451）与对照组（1420±426）之间评分无统计学意义(P>005)；6个月时治疗组HAMD评分（817±424）与治疗前（1471±447）比明显下降有统计学意义 (P<001)，而对照组(1513±439)与治疗前(1453±431)比无统计学意义异(P>005)，两组间比较有统计学意义(P<001)。两组UPDRS评分在治疗3个月、6个月与治疗前UPDRS评分比较均下降，有统计学意义(P<001)、但在3个月时两组之间评分比较无统计学意义(P>005)，但在6个月时两组之间评分比较有统计学意义(P<005)。结论补肾活血颗粒可改善帕金森病抑郁状态。
Abstract:
ObjectiveTo evaluate the clinical efficacy of Bushen Huoxue Granule(BSHXG) in treating Parkinsons disease with depression (PDD)． MethodsA randomized ，doubleblind ， controlled trial program was conducted．65 patients of PDD were randomly divided into treatment group( BSHX particle group, n=35) and control group (n=30)．The control group was treated with western medicine and placebo, while the BSHXG group was treated with BSHXG and western medicine. All patients were treated for 6 months ．Hamilton depression scale (HAMD ) and Unified Parkinsons Disease Rating Scale(UPDRS) for all patients were measured in the 3rd and 6th months posttreatment. ResultsHAMD scores in the two groups before treatment and 3 months of treatment showed no significant difference (P> 005), no significant difference in the treatment group（1422±451）and control group（1420±426）(P>005)；in the 6th month, the HAMD score of treatment group （817±424）decreased significantly compared with pretreatment（1471±447）, there was statistical significance(P<001), while there was no significant difference between the control group (1513±439) and pretreatment (1453±431) (P>005), the comparison between the two groups was statistically significant (P<001). UPDRS scores decreased in two groups after three months, and six months compared with pretreatment, there was statistically significant (P<001), while in the 3rd month ratings showed no significant difference between the two groups (P>005), but in the 6th month when the score between the two groups were significantly different (P<005).ConclusionsBushen Huoxue Granule(BSHXG) can effectively improve Parkinsons disease with depression (PDD).

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备注/Memo

备注/Memo:

作者单位：100853 北京，解放军医学院\[郭云霞（博士研究生）\]；解放军总医院中医科（郭云霞、李绍旦、杨明会）
作者简介：郭云霞（1976 ），女，2011级在读博士研究生。研究方向：中西医结合老年病。Email: guoyx1999@sina.com
通讯作者：杨明会（1962 ），教授，主任医师，博士生导师。中华中医药学会副会长，中国人民解放军中医药学会会长。研究方向：老年病中医研究。Email: ymh9651@yahoo.com.cn
更新日期/Last Update: 1900-01-01