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[1]周次利 赵继梦 吴璐一等.艾灸生成物对大鼠肺形态与脏器系数的影响[J].环球中医药,2014,7(06):406-0.
　ZHOU Ci li,ZHAO Ji meng,WU Lu yi,et al.Effect of moxibustion products on morphology and organ coefficients of lungs in rats[J].,2014,7(06):406-0.
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艾灸生成物对大鼠肺形态与脏器系数的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第7卷
期数:
2014年06期
页码:
406-0
栏目:
论著
出版日期:
2014-06-06

文章信息/Info

Title:
Effect of moxibustion products on morphology and organ coefficients of lungs in rats
作者:
周次利 赵继梦 吴璐一等
Author(s):
ZHOU Cili;  ZHAO Jimeng;  WU Luyi;  et al.
Shanghai Research Institute of Acupucture and Meridian, Shanghai 200030, China
关键词:
艾灸生成物; 安全性; 肺; 形态学; 脏器系数; 大鼠
Keywords:
Moxibustion products; Safety; Lungs; Morphology; Organ Coefficients; Rats
分类号:
R2458
DOI:
-
文献标志码:
A
摘要:
目的观察不同浓度艾灸生成物对SD大鼠肺的影响。方法40只大鼠随机分正常对照组、低剂量艾灸生成物组、中剂量艾灸生成物组、高剂量艾灸生成物组，高剂量艾灸生成物恢复组，每天在相应浓度艾灸生成物中暴露4小时，每周5天，持续2个月；高剂量艾灸生成物恢复组经2个月高剂量艾灸生成物刺激后，在空气中自然暴露21天作为恢复期。正常对照组大鼠不进行任何艾灸生成物干预，常规饲养2个月。肉眼、光学显微镜下观察各组大鼠肺的病理形态，比较各组大鼠肺脏器系数。结果肉眼下，除中、高剂量艾灸生成物组分别有1只大鼠肺部表面可见小的灰色或黑色斑点外，余各组别大鼠肺部均未见异常。光镜下，低、中、高剂量艾灸生成物组部分大鼠支气管及肺泡可见不同程度炎性细胞侵润，肺泡隔增厚，其中，高剂量艾灸生成物组较为明显。高剂量艾灸生成物恢复组大鼠支气管及肺泡炎性细胞侵润现象与肺泡隔增厚现象较高剂量艾灸生成物组大鼠明显减少。各组别大鼠肺脏器系数无统计学差异。结论艾灸生成物对大鼠肺形态的影响与艾灸生成物的浓度有一定相关性，艾灸生成物对大鼠肺形态的影响具有可逆性。
Abstract:
ObjectiveTo investigate the effect of different concentrations of moxibustion products on lungs of SD rats. MethodsForty rats were randomly divided into normal control group, lowdose moxibustion products group and middledose moxibustion products group and highdose moxibustion products group and highdose moxibustion products recovery group. Each group of rats were exposed 4h daily, 5d weekly, for 2 months. After highdose moxibustion products stimulation, rats in highdose moxibustion products recovery group were raised in normal air for 21d. Rats in normal control group were raised in normal air for without any moxibustion products stimulation. The morphology of lungs in each group rats were observed under naked eyes and optical microscope, and the organ coefficients of lungs were compared. ResultsUnder the naked eyes, except one rats lungs showed small gray or black spots respectively in middledose moxibustion products group and highdose moxibustion products group, the remaining rats lungs in each group were normal. Under optical microscope, different degrees of inflammatory cell infiltration in bronchi and alveoli and alveolar septa thickening showed in some rats in lowdose moxibustion products group, middledose moxibustion products group and highdose moxibustion products group, and obviously in highdose moxibustion products group. Inflammatory cell infiltration in bronchi and alveoli and alveolar septa thickening improved in in highdose moxibustion products recovery group. The organ coefficients of lungs were no significant difference in each group. ConclusionThere is relevance between the concentration of moxibustion product and its effect on morphology of rat lungs, and the effect can be reversible.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81102637）；上海高校青年教师培养资助计划（szy11067）；国家重点基础研究发展计划（2009CB522900）
作者单位：200030 上海中医药大学针灸经络研究所［周次利、赵继梦（博士研究生）、施茵、王晓梅、洪珏、刘世敏、吴焕淦］，上海市气功研究所［吴璐一（在职博士研究生）］，中医方证与系统生物学研究中心［廖文（博士研究生）］
作者简介：周次利（1980- ），女，博士。研究方向：艾及艾灸生成物安全性评价与针灸治疗胃肠疾病研究。Email: zhoucili2010@126.com
通讯作者：吴焕淦（1956- ），博士，教授。研究方向：针灸作用原理与应用规律研究。Email: wuhuangan@126.com
更新日期/Last Update: 1900-01-01