|本期目录/Table of Contents|

[1]孙海林 朱培芳 李文军等.云厚朴醇提物中厚朴酚与和厚朴酚降解动力学研究[J].环球中医药,2014,7(10):761-0.
　SUN Hai-lin,ZHU Pei-fang,LI Wei-jun,et al.Study on degradation kinetics of magnolol and honokiol in the ethanol extraction of magnolia rostrata[J].,2014,7(10):761-0.
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云厚朴醇提物中厚朴酚与和厚朴酚降解动力学研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第7卷
期数:
2014年10期
页码:
761-0
栏目:
论著
出版日期:
2014-10-06

文章信息/Info

Title:
Study on degradation kinetics of magnolol and honokiol in the ethanol extraction of magnolia rostrata
作者:
孙海林 朱培芳 李文军等
Author(s):
SUN Hai-lin; ZHU Pei-fang; LI Wei-jun; et al.
Pharmacy School,Yunnan University of Traditional Chinese Medicine,Kunming 650500,China
关键词:
云厚朴;  厚朴酚;  和厚朴酚;  动力学;  高效液相色谱
Keywords:
Magnolia rostrata;  Magnolol;  Honokiol;  Kinetics;  High performance liquid chromatography
分类号:
R284
DOI:
-
文献标志码:
A
摘要:
目的研究云厚朴醇提物中厚朴酚、和厚朴酚在贮放、浓缩、干燥工序中的降解规律。方法 通过高效液相色谱法测定云厚朴醇提物中厚朴酚与和厚朴酚在不同贮放、浓缩、干燥条件下的含量变化,得出降解规律。结果 云厚朴醇提液在室内常温下贮放20天,和厚朴酚、厚朴酚含量基本不变; 云厚朴醇提液在60℃浓缩和干燥,厚朴酚及和厚朴酚的降解动力学符合零级反应,在100℃降解较快。结论 云厚朴醇提液在室温下贮放20天基本稳定,但是不能长时间在高温条件下浓缩、干燥,以免有效成分损失,在100℃干燥时降解较快,制剂生产中应避免醇提液长时间高温干燥、浓缩。
Abstract:
Objective To study degradation law of magnolol and honokiol in the ethanol extraction of magnolia rostrata during storage, concentrating and drying.Methods To find the law of degradation, the contents of magnolol and honokiol were tested by high performance liquid chromatography under storage, concentrating and drying conditions.Results The content of magnolol and honokiol in the ethanol extraction remained almost the same within 20 days when kept indoors. The degradation reactions of magnolol and honokiol were zero-order when concentrating at 60℃ and drying. When drying at 100℃, the rate of degradation was faster.Conclusion Magnolol and honokiol in the ethanol extraction are almost stable within 20 days when kept indoors, but can not be dried and concentrated longer under higher temperature. The rate of degradation is faster when drying at 100℃. In order to ensure the preparation quality, higher temperature and longer time should be avoided during drying and concentrating for the ethanol extraction of magnolia rostrata.

参考文献/References:

[1] 国家药典委员会. 中华人民共和国药典(一部)[M].北京:中国医药科技出版社,2010:235.
[2]李平,何文妮,孙博航,等.厚朴的提取方法及质量分析考察[J].沈阳药科大学学报,2009,26(9):736-739.
[3]朱培芳,孙海林,李文军,等.HPLC测定云厚朴中厚朴酚及和厚朴酚含量[J].光谱实验室,2013,30(5):2155-2159.
[4]Su ZR,Dong TX,Lo CK,et al. Heat-induced Degradation of Magnolol and Honokiol in Supercritical Fluid CO2 Extraction of Cortex Magnolia Officinalis(Houpo)[J]. Acta Pharmaceutica Sinica,2002,37(11):870-875.

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备注/Memo

备注/Memo:
基金项目:云南省教育厅科学研究基金理工类重点项目(2012Z128C)
作者单位:650500 昆明,云南中医学院药学院
作者简介:孙海林(1977- ),硕士,讲师。研究方向:有机化学和药物稳定性。E-mail: sunhailin123456@sina.com 通讯作者:魏泽英(1964- ),硕士,副教授。研究方向:物理化学和药物稳定性。E-mail: janewei7@hotmail.com
更新日期/Last Update: 1900-01-01