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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:

第8卷

期数:

2015年01期

页码:

1-5

栏目:

论著

出版日期:

2015-01-06

文章信息/Info

Title:

Lung distension water diffusion due to deficiency of Yang syndrome channel protein correlation research

作者:

韦衮政; 潘承政; 钱锐; 陈必勤; 张馨予; 祁向荣; 欧阳丽; 林云; 邹映东

650031 昆明,云南省中医医院肺病科(韦衮政、钱锐、陈必勤、张馨予、祁向荣、欧阳丽),检验科(林云、邹映东); 云南中医学院临床医学院[潘承政(硕士研究生)]

Author(s):

WEI Gun-zheng; PAN Cheng-zheng; QIAN Rui; et al.

Yunnan province hospital of traditional Chinese medicine lung disease,Kunming 650031,China

关键词:

肺胀;  阳虚水泛;  水通道蛋白-2;  脑钠素;  钠钾三磷酸腺苷酶

Keywords:

Lung distension;  Water diffusion due to deficiency of Yang;  Aquaporin-2;  Brain natriuretic peptide;  Potassium sodium atpase

分类号:

R256.14

DOI:

10.3969/j.issn.1674-1749.2015.01.001

文献标志码:

A

摘要:

目的 寻找肺胀阳虚水泛证的关联性因素,探讨肺胀阳虚水泛证的病理机制。方法 对符合诊断标准的临床收治肺胀阳虚水泛证、肺肾气虚证、痰热郁肺证患者分别采用双抗体夹心酶联免疫法检测尿水通道蛋白-2(aquaporin-2,AQP₂)、放射免疫法检测血浆精氨酸加压素(arginine vasopressin,AVP)、酶联免疫吸附法检测血浆脑钠素(brain natriuretic peptide,BNP)、钠钾三磷酸腺苷酶(Na⁺-K⁺-ATPase)水平,对阳虚水泛证、肺肾气虚证、痰热郁肺证三证之间相同项目指标分别采用秩和检验法比较相互之间的差异性,用相关分析法比较证型内指标之间的相关性。结果 肺胀阳虚水泛证与痰热郁肺证的BNP水平有差异性(P<0.05),阳虚水泛证、肺肾气虚证、痰热郁肺证患者尿AQP₂以及血浆钠钾ATP酶、AVP之间无统计学差异(P>0.05),三组钠钾ATP酶与BNP之间有正相关性(P<0.05),阳虚水泛证组及肺肾气虚证组的钠钾ATP酶与AVP之间有显著正相关性(P<0.01); BNP与AVP之间有显著正相关性(P<0.01),阳虚水泛证AQP₂与AVP之间有显著正相关性(P<0.01)。结论 BNP可能是肺胀阳虚水泛证的关键因素之一,需住院的肺胀阳虚水泛证、肺肾气虚证、痰热郁肺证患者均有阳虚因素的存在,尿AQP₂以及血浆钠钾ATP酶、AVP可能是肺胀阳虚水泛证的内在因素之一。

Abstract:

Objective Looking for lung distension water diffusion due to deficiency of Yang the correlation factors of the card, explore the pathogenesis of lung distension water diffusion due to deficiency of Yang the card. Methods To conform to the diagnostic standard of clinical treated lung distension water diffusion due to deficiency of Yang syndrome, lung and kidney deficiency syndrome, phlegm yu lung heat syndrome patients, respectively, with double antibody sandwich enzyme-linked immunoassay detection of urine aquaporin-2(AQP₂), ria method to detect the plasma arginine vasopressin(AVP), enzyme-linked immunosorbent method to detect the plasma Brain natriuretic peptide(BNP), potassium sodium atpase enzyme levels.To water diffusion due to deficiency of Yang syndrome, lung and kidney deficiency syndrome, phlegm heat yu lung between the three certificates same project indicators Rank and inspection were used respectively to compare the differences between each other.Compared with the method of correlation analysis of the correlation between card type in the index. Results Lung distension water diffusion due to deficiency of Yang syndrome and phlegm heat yu lung of BNP level was Statistically significant(P<0.05), water diffusion due to deficiency of Yang syndrome, lung and kidney deficiency syndrome, phlegm heat yu lung syndrome in patients with no statistical difference between of urinary AQP₂ and plasma potassium sodium atpase with AVP(P>0.05).Three groups of has a positive correlation between potassium sodium atpase and BNP(P<0.05),Y water diffusion due to deficiency of Yang syndrome and lung and kidney deficiency syndrome group have significant positive correlation between potassium sodium atpase and AVP(P<0.01); significant positive correlation between the BNP and AVP(P<0.01), water diffusion due to deficiency of Yang card have significant positive correlation between AQP₂ and AVP(P<0.01). Conclusion The BNP may be lung distension water diffusion due to deficiency of Yang one of the key factors of the card.To be in hospital Lung distension of Water diffusion due to deficiency of yang syndrome, lung and kidney deficiency syndrome, phlegm heat yu lung syndrome patients have the existence of Yang deficiency factor,Urinary AQP₂ and plasma potassium sodium atpase, AVP may be lung distension water diffusion due to deficiency of Yang one of the internal factors of the card.

参考文献/References:

[1] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组.COPD诊治指南(2007年修订版)[J].继续医学教育,2007,21(2):31- 42.
[2] 周仲瑛.中医内科学[M].北京:中国中医药出版社,2003:120-122.
[3] 灵枢经[M].田代华,刘更生,整理.北京:人民卫生出版社,2005:80.
[4] 汉·张仲景.金匮要略[M].何任,何若苹,整理.北京:人民卫生出版社,2005:53.
[5] 中华中医药学会内科分会肺系病专业委员会.慢性阻塞性肺疾病中医诊疗指南(2011版)[J].中医杂志,2012,53(1):80- 84.
[6] 田代华.皇帝内经素问[M].北京:人民卫生出版社,2005:45-114.
[7] 韦衮政.肺胀阳虚水泛证型的特点[J].光明中医,2008,23(3):322.
[8] 唐庆娟,刘声远.水通道蛋白家族成员AQP₂的研究进展[J].国外医学·生理、病理科学与临床分册,2001,21(3):238.
[9] RoxasB,FarjahM,DanzigerRS.Aquaporin-2 transcript is differentially regu lated by dietary salt in Sprague-Daw ley and DahlSS/Jr rats[J].Biochem Biophys Res Commun,2002,296(3):755-758.
[10] 许顶立,殷晓燕,邓英姿,等.充血性心力衰竭患者尿液水通道蛋白-2的改变[J].中华内科杂志,2000,39(7):471.
[11] 卢武生,许顶立,孟素荣,等.充血性心力衰竭患者尿液水通道蛋白-2的临床检测[J].心脏杂志,2003,15(3):239.
[12] 王哲,刘春英,高原,等.肺气肿模型大鼠肾组织水通道蛋白2的表达及机制研究[J].中国病理生理杂志,2010,26(2):318-321.
[13] 余保军,张文武.慢性阻塞性肺疾病急性发作期血浆VP、尿液中AQP₂浓度变化研究[J].中国当代医药,2012,19(17):33-34.
[14] 侯宇虹,唐显春,潘金兵,等.慢性肺原性心脏病患者血浆精氨酸加压素、心钠素及肺动脉压测定[J].郑州大学学报(医学版),2008,43(5):974- 976.
[15] 王伟,赵洪,黄鹤,等.AECOPD心衰患者BNP、cTnI的变化及与心功能关系[J].临床肺科杂志,2010,15(12):1732-1733.
[16] 吴波,陈思怡,周明浩.慢性肺心病急性期患者的血浆BNP变化分析[J].医学信息,2010,23(12):4532- 4533.
[17] 冼绍祥,欧明.慢性充血性心力衰竭肾阳虚证与血管紧张素、脑钠素的关系研究[J].浙江中医杂志,2007,42(1):26-27.
[18] 曾雪山,李芳,李颖,等.肺心病心衰的中医证型与BNP浓度相关性研究[J].中国中医药现代远程教育,2012,10(22):90- 91.
[19] 潘承政,韦衮政.Na⁺-K⁺-ATP酶活性与阳虚证的内在联系探讨[J].环球中医药,2013,6(11):851- 853.
[20] 朱珍道,林求诚.心肾阳虚型充血性心力衰竭患者红细胞内ATP酶、SOD、钠钾钙镁及血清LPO的变化及其相互关系[J].实用中西医结合杂志,1998:11(2):131-132.
[21] 王敏,金润铭.Na⁺,K⁺-ATP酶信号转导功能的分子机制[J].国际病理科学与临床杂志,2006,26(3):228-231.
[22] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版)[J].全科医学临床与教育,2013,11(5):484- 491.

相似文献/References:

[1]韦衮政,韦莽,韦碧沙,等.肺胀阳虚水泛证的标本治则探讨[J].环球中医药,2013,6(02):117.
[2]赵艳,符兰英.自拟附苈强心汤治疗阳虚水泛型慢性心衰35 例[J].环球中医药,2015,8(09):1127.[doi:10.3969/j.issn.1674-1749.2015.09.029]
[3]徐未方,王冰,张琼.浅谈应用二陈汤合方从“痰”论治肺胀[J].环球中医药,2016,9(02):237.[doi:10.3969/j.issn.1674-1749.2016.02.041]
[4]韦衮政 潘承政 钱锐等.肺胀常见证候心肺功能特点[J].环球中医药,2014,7(07):515.
　WEI Gun-zheng,PAN Cheng-zheng,QIAN Rui,et al.The characteristics of cardiopulmonary function in common syndrome types of traditional Chinese medicine lung distension disease[J].,2014,7(01):515.

备注/Memo

备注/Memo:

基金项目:云南省科技厅科研基金(2009ZC154M) 作者简介:韦衮政(1964- ),博士,副主任医师。研究方向:肺系疾病临床研究。E-mail: weigunzheng@qq.com

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更新日期/Last Update: 2015-01-05