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[1]张杰,张颖,孟惠彦,等.西黄胶囊辅助乳腺癌患者全程化疗的临床研究[J].环球中医药,2015,8(01):9-12.[doi:10.3969/j.issn.1674-1749.2015.01.003]
　ZHANG Jie,ZHANG Ying,MENG Hui-yan,et al.Clinical study of Xihuang Capsules as an adjuvant therapy for breast-cancer patients undergoing chemotherapy[J].,2015,8(01):9-12.[doi:10.3969/j.issn.1674-1749.2015.01.003]
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西黄胶囊辅助乳腺癌患者全程化疗的临床研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年01期
页码:
9-12
栏目:
论著
出版日期:
2015-01-06

文章信息/Info

Title:
Clinical study of Xihuang Capsules as an adjuvant therapy for breast-cancer patients undergoing chemotherapy
作者:
张杰; 张颖; 孟惠彦; 李航; 杨帅; 姚天; 张风华
050051 石家庄,河北省人民医院普外一科[张杰(硕士研究生)、张颖、孟惠彦、李航(硕士研究生)、杨帅(硕士研究生)、姚天(硕士研究生)、张风华]; 河北医科大学研究生学院[张杰(硕士研究生)、李航(硕士研究生)、杨帅(硕士研究生)、姚天(硕士研究生)]
Author(s):
ZHANG Jie; ZHANG Ying; MENG Hui-yan; et al.
First Department of Gerenal Surgery,Hebei General Hospital,Shijiazhuang 050051, China Corresponding author:ZHANG Feng-hua,E-mail:z139338@126.com
关键词:
乳腺癌;  西黄胶囊;  化疗副反应;  生活质量
Keywords:
Breast cancer;  Xihuang Capsule;  Adverse reaction of chemotherapy;  Quality of life
分类号:
R737.9
DOI:
10.3969/j.issn.1674-1749.2015.01.003
文献标志码:
A
摘要:
目的 观察西黄胶囊对于乳腺癌患者全程化疗毒副反应的影响及化疗后生活质量、体力状况的临床前瞻性研究。方法 按随机数字表法随机抽取河北省人民医院普外一科2012年9月至2014年8月乳腺癌患者90例,完全随机分为治疗组与对照组,治疗组45例,空白对照组45例,均采用Anthracycline and Cyclophosphamide(AC)×4→Taxol(T)×4方案化疗,治疗组加用口服西黄胶囊,8粒/次,2次/天辅助全程化疗。化疗结束后,对近期疗效进行评估,评估指标包括两组患者的体力状况、生活质量以及化疗毒副反应。结果 研究发现应用西黄胶囊治疗组体力状况稳定及提高率明显高于对照组,具有统计学差异(P<0.05); 生活质量评价中,治疗组各项指标均优于对照组,具有统计学差异(P<0.05); 对两组患者毒副反应发生情况分别进行统计学分析,治疗组较对照组部分化疗毒副反应明显减轻(P<0.05)。结论 全程化疗中应用西黄胶囊可以降低乳腺癌患者部分化疗药物的毒副作用,改善患者的体力状况及生活质量。
Abstract:
Objective This prospective study aimed to examine the effect of Xihuang Capsules on the adverse reactions of chemotherapy in breast-cancer patients and on their quality of life and physical conditions..Methods According to the random number table method, 90 cases with breast cancer were selected among the patients from those who received treatment in Hebei general hospital from September 2012 to August 2014, and were randomly assigned to the treatment group and control group, with 45 cases in each group. Both groups underwent Anthracycline(Pirarubicin)and Cyclophosphamide(AC)×4→Taxol(Docetaxel, T)×4 chemotherapy protocol. In addition, the treatment group received Xihuang Capsules, 8 capsules a time, 2 times a day for the whole-course chemotherapy treatment. Short-term efficacy was assessed during the whole follow-up process. End points were patients' physical condition, quality of life and chemotherapy-induced toxic effects. Results The stability in physical conditions and improvement rate were significantly higher in the treatment group than in the control group(P< 0.05). Quality of life in various aspects was significantly improved in the treatment group as compared with the control group(P<0.05). Some chemotherapy-induced toxic effects were markedly alleviated in the treatment group as compared with the control group(P<0.05).Conclusions The addition of Xihuang Capsules as an adjuvant therapy for chemotherapy reduces drug-induced toxic effects, improves the physical conditions and quality of life for patients with breast cancer.

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备注/Memo

备注/Memo:
作者简介:张杰(1986- ),女,2013级在读硕士研究生。研究方向:腺体外科。 E-mail:smartgirl0312@163.com 通讯作者:张风华(1970- ),女,博士,副主任医师,副教授。研究方向:腺体外科。E-mail:z139338@126.com
更新日期/Last Update: 2015-01-05