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[1]聂莉媛,鄢泽然,张青,等.柴贝止痫汤添加治疗难治性癫痫复杂部分性发作的临床研究[J].环球中医药,2015,8(01):13-18.[doi:10.3969/j.issn.1674-1749.2015.01.004]
　NIE Li-yuan,YAN Ze-ran,ZHANG Qing,et al.Clinical study of the combination of Chaibei Zhixian Decoction with anti-epilepsy drugs in the treatment of intractable epilepsy complex partial seizures[J].,2015,8(01):13-18.[doi:10.3969/j.issn.1674-1749.2015.01.004]
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柴贝止痫汤添加治疗难治性癫痫复杂部分性发作的临床研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年01期
页码:
13-18
栏目:
论著
出版日期:
2015-01-06

文章信息/Info

Title:
Clinical study of the combination of Chaibei Zhixian Decoction with anti-epilepsy drugs in the treatment of intractable epilepsy complex partial seizures
作者:
聂莉媛; 鄢泽然; 张青; 王潇慧; 王越; 孙金; 张媛; 刘金民
100078 北京中医药大学东方医院脑病科[聂莉媛(博士研究生)、张青(博士研究生)、王潇慧(硕士研究生)、张媛(硕士研究生)]; 北京中医药大学第三附属医院[刘金民、孙金(博士研究生)]; 中日友好医院中医风湿科(鄢泽然); 天津中医药大学第二附属医院急诊科(王越)
Author(s):
NIE Li-yuan;  YAN Ze-ran;  ZHANG Qing;  et al.
Department of Encephalopathy, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China Corresponding author: LIU Jin-min, E-mail: jmvip@vip.163.com
关键词:
柴贝止痫汤;  难治性癫痫;  复杂部分性发作
Keywords:
Chaibei Zhixian Decoction;  Intractable epilepsy;  Complex partial seizures
分类号:
R742.1
DOI:
10.3969/j.issn.1674-1749.2015.01.004
文献标志码:
A
摘要:
目的 观察评价刘金民教授治疗难治性癫痫经验用方柴贝止痫汤联合抗癫痫药物(anti-epileptic drugs, AEDs)治疗难治性癫痫复杂部分性发作的临床疗效和安全性。方法 选择符合诊断和纳入标准的病例60例,随机分为治疗组和对照组,分别给予AEDs添加柴贝止痫汤及单纯的AEDs治疗。定期随诊并记录治疗后患者的痫性发作频率、中医症状积分及不良反应等。以痫性发作频率、中医症状积分及脑电图异常程度的改善程度作为疗效判定标准。结果 在改善患者的痫性发作频率方面,经Wilcoxon秩和检验,治疗12周后,治疗组疗效优于对照组(P<0.05); 经χ2检验,治疗8周、12周后,治疗组疗效优于对照组(P<0.05)。在改善患者的中医症状积分方面,经Repested Measures检验(Greenhouse-Geisser法校正),治疗4周、8周、12周的不同观测时点、观测时点与组别的交互作用及组别之间的差异均具有统计学意义(P<0.05); 经χ2检验,治疗8周、12周后,治疗组疗效优于对照组(P<0.05); 经秩和检验,治疗4周后,在失眠症状积分上,治疗组疗效优于对照组(P<0.05),治疗8周、12周后,在胸闷、痰多、疲乏、失眠四个症状积分上,治疗组疗效优于对照组(P<0.05)。结论 柴贝止痫汤添加用药治疗难治性癫痫复杂部分性发作,在改善患者的痫性发作频率及中医症状积分上均有明显的优势,且随着疗程的延长,疗效逐渐显著,未发现任何不良反应。柴贝止痫汤添加治疗难治性癫痫复杂部分性发作安全、有效。
Abstract:
Objective To observe and assess the clinical efficacy and safety of Prof. LIU Jin-min's Chaibei Zhixian Decoction in combination with AEDs in the treatment of intractable epilepsy complex partial seizures.Methods A total of 60 eligible patients who met the diagnostic criteria and enrollment requirements were randomly divided into treatment group which was assigned to receive AEDs in combination with Chaibei Zhixian Decoction and control group which was assigned to receive AEDs alone. After treatment, all patients were regularly followed up, and their seizure frequency, traditional Chinese medicine(TCM)symptom scores and adverse reactions were recorded. The coprimary efficacy end points were seizure frequency, TCM symptom scores and the improvement of abnormality of EEG.Results In seizure frequency, after 12-week treatment, Wilcoxon rank sum test revealed a better therapeutic benefit in the treatment group than in the control group(P<0.05); Chi-square test showed a better therapeutic efficacy in the treatment group than in the control group after 8 and 12 weeks' treatment(P<0.05). In TCM symptom scores, repetitive measure analysis of variance(ANOVA)showed statistically significant differences at time point, groups and the interaction of time point by groups after 4, 8 and 12 weeks' treatment(P<0.05); Chi-square test showed a better therapeutic efficacy in the treatment group than in the control group after 8 and 12 weeks' treatment(P<0.05). As for insomnia score, rank test revealed a better therapeutic efficacy with the treatment group as compared with the control group after 4-week treatment(P<0.05). After 8 and 12 weeks' treatment, therapeutic efficacies in chest tightness, phlegm, fatigue, insomnia scores were better in the treatment group than in the control group(P<0.05).Conclusion In the treatment of intractable epilepsy complex partial seizures, the combination of Chaibei Zhixian Decoction with AEDs has remarkable benefits in improving seizure frequency and TCM symptom scores. Moreover, the efficacy is more prominent as the treatment course is prolonged, without any obvious adverse reactions. The combination of Chaibei Zhixian Decoction with AEDs is safe and effective for intractable epilepsy complex partial seizures.

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备注/Memo

备注/Memo:
基金项目:北京市教育委员会共建项目建设计划; 北京中医药大学科研创新团队资助项目(2011-CXTD-23) 作者简介:聂莉媛(1987- ),2013级在读博士研究生。研究方向:中医药防治脑病临床及基础研究。E-mail: nlydoctor@163.com 通讯作者:刘金民(1965- ),博士,教授,主任医师。研究方向:中医内科急症及发作性脑病的中医药治疗。E-mail: jmvip@vip.163.com
更新日期/Last Update: 2015-01-05