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[1]王苏,樊永平,杨涛,等.肝肾阴虚型视神经脊髓炎和多发性硬化患者血清补体及免疫球蛋白水平比较[J].环球中医药,2015,8(01):22-25.[doi:10.3969/j.issn.1674-1749.2015.01.006]
　WANG Su,FAN Yong-ping,YANG Tao,et al.Comparison of serum complement and Immunoglobulin levels of neuromyelitis optica and multiple sclerosis patients with deficiency of kidney-liver Yin syndrome[J].,2015,8(01):22-25.[doi:10.3969/j.issn.1674-1749.2015.01.006]
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肝肾阴虚型视神经脊髓炎和多发性硬化患者血清补体及免疫球蛋白水平比较()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年01期
页码:
22-25
栏目:
论著
出版日期:
2015-01-06

文章信息/Info

Title:
Comparison of serum complement and Immunoglobulin levels of neuromyelitis optica and multiple sclerosis patients with deficiency of kidney-liver Yin syndrome
作者:
王苏; 樊永平; 杨涛; 万江龙
100070 北京中医药大学第一临床医学院[王苏(博士研究生)]; 首都医科大学附属北京天坛医院(樊永平、杨涛、万江龙)
Author(s):
WANG Su; FAN Yong-ping; YANG Tao; et al.
The Firsth Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100700,China Corresponding author:FAN Yong-ping,E-mail:yongpingf@hotmail.com
关键词:
视神经脊髓炎;  多发性硬化;  肝肾阴虚;  补体;  免疫球蛋白
Keywords:
Neuromyelitis Optica;  Multiple Sclerosis;  Deficiency of kidney-liveryin;  Complement;  Immunoglobulin
分类号:
R744.5+2
DOI:
10.3969/j.issn.1674-1749.2015.01.006
文献标志码:
A
摘要:
目的 观察肝肾阴虚型视神经脊髓炎(neuromyelitis optica,NMO)与多发性硬化(multiple sclerosis,MS)患者血清免疫球蛋白和补体的表达水平。方法 观察2012年10月至2014年6月就诊于首都医科大学附属北京天坛医院中医科门诊的NMO患者20例,作为NMO组,MS患者10例,作为MS组; 11例健康志愿者作为对照组。记录NMO组及MS组患者发病年龄、病程及复发次数,并进行扩展残疾量表评分(Expanded Disability Status Scale,EDSS)。采用免疫比浊法定量 测定三组血清中补体成分3(C3)、补体成分4(C4)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)及免疫球蛋白M(IgM)水平。结果 与MS组比较,NMO组患者的病程长、复发次数多(P<0.05),其EDSS评分较高、发病年龄较早,但差异无统计学意义(P>0.05)。NMO组患者补体C3水平与对照组比较显著降低(P<0.05),亦低于MS组(P<0.01),而MS组与对照组间无显著差异(P>0.05)。NMO患者补体C3水平与发病年龄、病程、复发次数及EDSS评分均无显著相关性(P>0.05)。NMO组血清补体C4水平略低于对照组,差异无统计学意义(P>0.05),但显著低于MS组(P<0.01),MS组与对照组间无显著差异(P>0.05)。NMO组、MS组患者的IgG、IgA、IgM水平与对照组比较均无显著差异(P>0.05),两组间差异亦无统计学意义(P>0.05)。结论 NMO的发病过程中补体C3激活起到了重要作用,在缓解期部分患者仍存在补体水平降低,这对于鉴别NMO与MS具有一定意义。
Abstract:
Objective To observe the levels of complement and immunoglobulin in serum of neuromyelitis optica and multiple sclerosis patients with deficiency of kidney-liver yin syndrome. Methods 20 patients with NMO visiting at traditional medicine Department of Beijing Tiantan hospital affiliated capital medical university during 10,2012 to 06,2014 were divided into NMO group, and 10 patients with MS were divided into MS group,11 healthy volunteer were in control group. The age of onset, duration, frequency of recurrence and Expanded Disability Scale score(EDSS score)of NMO and MS patients were recorded.The levels of complement component 3(C3), complement component 4(C4), immunoglobulin G(IgG), immunoglobulin A(IgA)and immunoglobulin M(IgM)in serum were detected by Immunoturbidimetry.Results NMO patients had longer duration, more recurrence compared with the MS group(P<0.05), and their EDSS score was higher, age of onset was earlier, but the difference was not statistically significant(P>0.05).Complement 3 levels in serum of patients with NMO group were significantly lower than control group(P<0.05), and also lower than MS group(P<0.01), but there was no significant difference between the MS group and the control group(P>0.05). The complement 3 levels of NMO patients and the age of onset, duration, recurrence, EDSS scores were not significantly correlated(P>0.05). The serum complement 4 levels in NMO group were slightly lower than the control group(P>0.05), but significantly lower than MS group(P<0.01), there was no significant difference between the MS group and the control group(P>0.05). The IgG, IgA, IgM levels between three groups were not significantly different(P>0.05).Conclusion Complement 3 activation plays an important role in the pathogenesis of NMO. The complement levels of some patients are still reduced even during remission, which has some significance for the identification of NMO and MS.

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相似文献/References:

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　WANG Su,FAN Yong-ping,ZHANG Yong-chao,et al.Comparison of clinical features of Neuromyelitis Optica patients with different TCM syndrome types[J].,2014,7(01):833.

备注/Memo

备注/Memo:
基金项目:北京市卫生系统高层次卫生技术人才培养计划(2011-2- 09); 国家自然科学基金(81173237); 北京市自然科学基金(7142053) 作者简介:王苏(1986- ),女,2012年在读博士研究生,研究方向:中医脑病学研究。E-mail:wangsu.1986@163.com 通讯作者:樊永平(1965- ),博士,教授,博士生导师。研究方向:中西医结合神经系统疾病临床和研究。E-mail:yongpingf@hotmail.com
更新日期/Last Update: 2015-01-05