«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:

第8卷

期数:

2015年01期

页码:

42-45

栏目:

论著

出版日期:

2015-01-06

文章信息/Info

Title:

Experimental research of balance acupuncture on rabbit's periarthritis of shoulder model for the influence of transforming growth factor beta 1, prostaglandin E-2 and hydroxyproline

作者:

袁红; 陈榕; 黄大鹏; 武燕; 王颖; 王文远; 陈锋

100029 北京中医药大学针灸推拿学院

Author(s):

YUAN Hong; CHEN Rong; HUANG Da-peng; et al.

College of Acumox and Tuina,Beijing university of Chinese medecine,Beijing 100029,China Corresponding author:YUAN Hong,E-mail:yuanhong1109@sina.com

关键词:

平衡针;  肩关节周围炎;  转化生长因子-β1;  前列腺素-E2;  羟脯氨酸

Keywords:

Balance Acupuncture;  Scapulohumeral Periarthritis;  Transformating growth factor-β1;  Prostaglandin E-2;  Hydroxyproline

分类号:

R245.3

DOI:

10.3969/j.issn.1674-1749.2015.01.011

文献标志码:

A

摘要:

目的 探讨平衡针对家兔肩关节周围炎症治疗的作用及机制。方法 家兔随机分为空白组、模型组和平衡针治疗组。采用持续机械劳损加冰敷造成肩周炎家兔模型,观察模型兔关节运动及患侧关节周围组织的病理变化并检测血浆和患侧局部组织中的转化生长因子-β1(transformating growth factor-β1,TGF-β1)和前列腺素-E2(prostaglandin E-2,PGE-2)及羟脯氨酸(hydroxyproline,HYP)的含量。结果 采用单因素ANOVA,统计结果用LSD进行分析,得出平衡针组家兔肱二头肌中转化生长因子-β1(transformating growth factor-β1,TGF-β1)及冈上肌中前列腺素-E2(prostaglandin E-2,PGE-2)含量均较模型组明显降低,统计学差异极显著(P<0.01)。结论 平衡针通过降低模型兔肩关节周围组织中转化生长因子-β1(transformating growth factor-β1,TGF-β1)、前列腺素-E2(prostaglandin E-2,PGE-2)及炎性组织中羟脯氨酸(hydroxyproline,HYP)的含量,实现消除水肿、镇痛、抗炎作用,值得在临床推广和应用。

Abstract:

Objective Explore the effects and mechanism of rabbit scapulohumeral periarthritis(SP )model treated by balanced acupuncture. Methods Rabbits were divided into a blank group, a model group and a balanced acupuncture group. Establish the rabbit SP model by using persistent mechanical strain and ice compress. Observing the activities of rabbit sp model and the pathological change of tendon of the tissue around the shoulder joint.Test the content of transforming growth factor-β1、prostaglandin E2 and hydroxyproline in plasma and local tissue.Results Use Single factor ANOVA to analyse the experimental data,the results showed that compared with model group,rabbit in the balanced acupuncture group presented both TGF-β1 in biceps and PGE-2 in supraspinatus muscle significantly lower, the difference was statistically significant(P<0.01).Conclusion Balanced acupuncture by reducing the content of interleukin-1β, transforming growth factor-β1and prostaglandin E2 in the tissue around the shoulder joint of rabbit SP model and hydroxyproline in the inflammatory tissue to make the effects of eliminating edema,analgesia and anti-inflammatory. Balanced acupuncture by reducing the content of anti-pain factors and inflammatory factors to improve the organization and adhesion of the local pathological tissue of rabbit SP model, then effectively treat the local and systemic syndromes. So it is valuable for widespread applying in clinic treatment.

参考文献/References:

[1] 刘立艳,徐静.针灸推拿治疗肩周炎的研究进展[J].哈尔滨医药,2008,28(6):50-52.
[2] 齐秋俊,秦华.针灸推拿治疗肩周炎研究进展(综述)[J].中医中药,2009,8(4):109-111.
[3] 刘圣,王保卫,杨洪,等.针刺肩痛穴治疗肩周炎临床疗效观察[J].中华中医药学刊,2007,25(2):282.
[4] 杨仲岐.针刺肩痛穴治疗肩周炎50例[J].湖南中医学院学报,2000,20(2):66.
[5] 王文远,张利芳.针刺肩痛穴治疗外伤性肩周炎3850例[J].中医外治杂志,2008,17(3):48- 49.
[6] 王文远,孙永慧,齐迎春,等.肩痛穴平衡针灸治疗偏瘫性肩关节周围炎168例[J].中国临床康复,2005,(41):67,72.
[7] 王飞,王翔,魏素英.平衡针刺肩痛穴治疗肩周炎60例疗效分析[J].中国民间疗法,1995,(5):10.
[8] 王文远.针刺肩痛穴治疗肩周炎技术[J].中国社区医师,2007,23(3):33.
[9] 熊昌源,毕学薇,沈林,等.兔肩周炎的模型复制及相关生化指标测定[J].中国骨伤,1995,9(4):11-14.
[10] 王晨遥,方剑桥,邵晓梅,等.肩髃穴电针对肩关节周围炎家兔模型的干预作用[J].浙江中医药大学学报,2007,31(4):478- 482.
[11] 熊昌源,毕学薇,刘松林,等.持续机械劳损加冰敷复制实验性兔肩关节周围炎的病理学观察[J].中医药研究,1995,(5):52-54.
[12] 王俊生,卫文婷,王颖.平衡针治疗肩周炎的回顾性研究[J].中华中医药杂志,2010,25(9):1451-1455.
[13] 刘纯杰,张兆山.转化生长因子β的生物学特性、功能及其临床应用前景[J].生物技术通讯,2001,12(4):42- 44.
[14] 王春阳.细胞因子在软组织损伤修复中的作用[J].广州体育学院,2005,25(3):81- 82.
[15] 鄢飞,鲍同柱.转化生长因子-β与软组织创伤愈合的研究进展[J].中国民康医学,2008,20(8):77-79.

相似文献/References:

备注/Memo

备注/Memo:

基金项目:国家重点基础研究发展计划(973计划)(2007CB512700) 作者简介:袁红(1962- ),女,硕士,教授。研究方向:针刺作用机理研究。E-mail:yuanhong1109@sina.com

常用功能

更新日期/Last Update: 2015-01-05