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[1]李贞玉,杨惠民,郭杨志,等.血脂异常患者中医证型及血清sICAM-1、sVCAM-1水平与幽门螺旋杆菌感染的相关性研究[J].环球中医药,2015,8(02):137-140.[doi:10.3969/j.issn.1674-1749.2015.02.003]
　LI Zhen-yu,YANG Hui-min,GUO Yang-zhi,et al.Correlation study between the TCM syndromes of dyslipidemia, the level of serum sICAM-1,sVCAM-1 and helicobacter pylori infection[J].,2015,8(02):137-140.[doi:10.3969/j.issn.1674-1749.2015.02.003]
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血脂异常患者中医证型及血清sICAM-1、sVCAM-1水平与幽门螺旋杆菌感染的相关性研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年02期
页码:
137-140
栏目:
论著
出版日期:
2015-02-06

文章信息/Info

Title:
Correlation study between the TCM syndromes of dyslipidemia, the level of serum sICAM-1,sVCAM-1 and helicobacter pylori infection
作者:
李贞玉; 杨惠民; 郭杨志; 王林; 李璐
100700北京中医药大学第一临床医学院[李贞玉(博士研究生)]; 北京中医药大学东直门医院老年病科(杨惠民、郭杨志、王林、李璐)
Author(s):
LI Zhen-yu;  YANG Hui-min;  GUO Yang-zhi; et al.
The first clinical medical college, Beijing University of Chinese Medicine, Beijing 100700, China Corresponding author:YANG Hui-min, yanghuimin012005@163.com
关键词:
血脂异常;  动脉粥样硬化;  中医证型;  幽门螺旋杆菌;  炎性因子
Keywords:
Dyslipidemia;  Atherosclerosis;  The TCM syndromes;  Helicobacter pylori;  Inflammatory factors
分类号:
R259
DOI:
10.3969/j.issn.1674-1749.2015.02.003
文献标志码:
A
摘要:
目的 研究不同中医证型的血脂异常患者与幽门螺旋杆菌(helicobacter pylori,Hp)感染的关系,以及Hp感染对血脂异常患者血清炎症因子的影响。方法 对120例血脂异常患者及20例健康对照者的流行病学信息、中医证型、血脂、血清Hp特异性抗体(helicobacter pylori immunoglobulin G,HpIgG)、细胞间黏附分子-1(soluble intercellular adhesion molecule-1,sICAM-1)、血管细胞黏附分子-1(soluble vascular cell adhesion molecule-1,sVCAM-1)水平进行检测,并采用非参数检验及一元线性回归的方法进行分析。结果 血清HpIgG表达水平从高到低为肝肾阴虚组>脾肾阳虚组>阴虚阳亢组>气滞血瘀组>痰浊阻滞组>健康对照组(P<0.01)。血脂异常组各中医证型患者血清HpIgG表达水平均显著高于对照组(P<0.01),肝肾阴虚组患者血清HpIgG表达水平与痰浊阻滞组间差异具有显著统计学意义(P<0.01)。血脂异常患者血清HpIgG水平与sICAM-1(r=0.236,P<0.01)、sVCAM-1(r=0.253,P<0.01)表达水平均成正相关关系。结论 血脂异常患者血清HpIgG水平明显高于健康对照组,且不同中医证型的血脂异常患者血清HpIgG水平具有差异性,Hp感染可能通过参与炎性因子的激活,从而促使动脉粥样硬化的发生发展。
Abstract:
Objective The study aims to research the relationship between the traditional Chinese medical(TCM)syndromes of dyslipidemia patients and helicobacter pylori(Hp)infection, and the effects of Hp infection on serum inflammatory factors of patients with dyslipidemia. Methods Detect and analyzethe epidemiological information, TCM syndromes, level of serum helicobacter pylori immunoglobulin G(HpIgG),soluble intercellular adhesion molecule-1(sICAM-1)and soluble vascular cell adhesion molecule-1(sIVCAM-1)of 120 patients with dyslipidemia and 20 healthy controls according with conditions. Use nonparametric test and unary linear regression method to analyze. Results The expression level of serum HpIgG in descending order is: deficiency of liver-kidney yin group>deficiency of spleen-kidney yang group>yin deficiency and yang excess group>qi stagnation and blood stasis group>turbid-phlegm obstructing group>healthy controls group(P<0.01).Level of serum HpIgG in the patients of all groups with dyslipidemia is significantly higher than healthy controls group(P<0.01).What's more, level of serum HpIgG in patients of deficiency of liver-kidney yin group has a significant difference compared with turbid-phlegm obstructing group(P<0.01). The serum HpIgG level of dyslipidemia patients is positive correlation to the level of serum sICAM-1(r=0.236,P<0.01),sVCAM-1(r=0.252,P<0.01).Conclusion Level of serum HpIgG in the patients with dyslipidemia is significantly higher than healthy controls group. There is statistically difference among levels of serum HpIgG in different TCM syndrome groups. Helicobacter pylori infection may drive AS by participating in activation of serum inflammatory factors.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:北京中医药大学自主选题(2014-JYBZZ-XS-189) 作者简介:李贞玉(1987-),女,2012级在读博士研究生。研究方向:中医药防治老年病。E-mail:lizy0124@163.com 通讯作者:杨惠民(1957-),硕士,教授,主任医师,博士生导师。研究方向:中医药防治老年病。E-mail:yanghuimin012005@163.com
更新日期/Last Update: 2015-02-20