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[1]孙雅姝,张璐,潘婷,等.基于药物体系质量评价模式的白芷质量表征关联分析研究[J].环球中医药,2015,8(03):266-273.[doi:10.3969/j.issn.1674-1749.2015.03.003]
　SUN Ya-shu,ZHANG Lu,PAN Ting,et al.Quality characterization and correlation analysis of Baizhi(Angelica Dahurica)based on a new quality evaluation model of drug system[J].,2015,8(03):266-273.[doi:10.3969/j.issn.1674-1749.2015.03.003]
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基于药物体系质量评价模式的白芷质量表征关联分析研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年03期
页码:
266-273
栏目:
述评
出版日期:
2015-03-06

文章信息/Info

Title:
Quality characterization and correlation analysis of Baizhi(Angelica Dahurica)based on a new quality evaluation model of drug system
作者:
孙雅姝; 张璐; 潘婷; 温静; 迟蕾; 黄亚婷; 李焕娟; 孙道涵; 姜艳艳; 石任兵
100102北京中医药大学中药学院 国家中医药管理局中药经典名方有效物质发现重点实验室[(孙雅姝(硕士研究生)、张璐(硕士研究生)、潘婷(硕士研究生)、李焕娟(硕士研究生)、迟蕾(硕士研究生)、黄亚婷(硕士研究生)、孙道涵(硕士研究生)、姜艳艳、石任兵]; 首都医科大学中医药学院[温静(硕士研究生)]; 北京市教委中药质量控制技术工程中心(姜艳艳、石任兵)
Author(s):
SUN Ya-shu; ZHANG Lu; PAN Ting; et al.
Key Unit of Exploring Effective Substances of Classical and Famous Formulas of State Administration of Traditional Chinese Medicine,School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 100102,China Corresponding author:SHI Ren-bing,E-
关键词:
白芷;  绿原酸;  花椒毒酚;  佛手柑内酯;  欧前胡素;  异欧前胡素;  质量评价;  关联分析
Keywords:
Angelica dahurica;  Chlorogenic acid;  Xanthotol;  Bergapten;  Imperatorin;  Isoimperatorin;  quality evaluation;  correlation analysis
分类号:
R284.1
DOI:
10.3969/j.issn.1674-1749.2015.03.003
文献标志码:
A
摘要:
目的 应用药物体系质量评价模式,对基于药物体系的白芷中各有效指标性成分进行含量测定并进行关联分析,全面表征与评价白芷质量。方法 采用HPLC-PDA法对白芷中绿原酸、花椒毒酚、佛手柑内酯、欧前胡素、异欧前胡素等5种有效指标性成分的含量进行同时测定。结果 基于药物体系质量评价模式,对白芷中有效指标性成分含量及其相对比值进行质量表征,同时将不同批次饮片与经过药效验证的基准批次饮片进行关联度分析。结果表明,批次2、3、13、17、21中有效指标性成分含量总体高于基准批次饮片20,批次1、5、9、11、22、24中有效指标性成分含量与批次20接近,批次5、11、1、24、9、3、13、19与批次20质量关联度较高。综合质量表征及关联分析结果,批次3、13、2、17、21、1、5、9、11、22、24质量优良度位于前列。结论 基于药物体系质量评价模式,以具有确切药效的白芷饮片为基准,对白芷质量进行关联分析研究,可全面地评价白芷饮片质量,优选白芷资源。
Abstract:
Objective Based on quality evaluation model of drug system, to determine the content and analyze correlation of effective index components in drug system of Baizhi(Angelica dahurica), for the comprehensive quality of characterization and evaluation of angelica dahurica. Methods Use HPLC-PDA method for simultaneous determination of 5 effective index components in twenty-four numbers of Baizhi(Angelica dahurica), including Chlorogenic acid, Xanthotol, Bergapten, Imperatorin and Isoimperatorin. Results Based on quality characterization model of drug system, to represent quality based on the content and the content relative ratio of effective index components and analyze correlation between the reference which its therapeutic effect has been identified and other samples. The result shows the total content of effective index components in No.2, No.3, No.13, No.17 and No.21 are higher than No.20, and No.1, No.5, No.9, No.11, No.22 and No.24 are closer to No.20. Compared with No.20, the correlation degree of quality representation of No.5, No.11, No.1, No.24, No.9, No.3, No.13, No.19 is higher. Consolidated quality characterization and correlation analysis, the quality of No.3, No.13, No.2, No.17, No.21, No.1, No.5, No.9, No.11, No.22 and No.24 are excellent. Conclusion Using quality evaluation model based on drug system, and with the exact therapeutic effect Angelica dahurica slices as a benchmark, for correlation analysis of quality research of Angelica dahurica which can comprehensively evaluate the quality of Angelica dahurica yinpian, providing the basis for looking for resources of Angelica dahurica.

参考文献/References:

[1] 国家药典委员会.中华人民共和国药典(一部)[M].北京:中国医药科技出版社,2010:357.
[2] 万焱,马国柱,冯素香.白芷中欧前胡素和异欧前胡素的含量测定[J].中医学报,2013,28(8):1178-1179.
[3] 毛志青,孟祥乐,李亚利,等.HPLC法测定白芷中4个香豆素类成分含量[J].中国药师,2011,14(2):205-207.
[4] 左胜.基于抗偏头痛药物体系的白芷方药物制备工艺与质量控制方法研究[D].北京:北京中医药大学,2014.
[5] 石任兵,王永炎.自然药学观的相关性思考[J].北京中医药大学学报,2012,35(4):221-225.
[6] 石任兵,王永炎,姜艳艳,等.论中药化学发展近况[J].北京中医药大学报,2012,35(3):153-159.
[7] 左胜,孙雅姝,石任兵,等.基于药物体系的藁本质量评价研究[J].北京中医药大学学报,2014,37(7):481- 485.
[8] 梅莹莹,许舒娅,左胜,等.基于药物体系的连翘饮药物制备物质量表征分析研究[J].北京中医药大学学报,2014,37(5):338-343.
[9] 安琪,唐雪阳,卢广英,等.紫苏方药物制备物的质量表征及其关联分析[J].北京中医药大学学报,2014,37(6):337-343.

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备注/Memo

备注/Memo:
基金项目:国家“十二五”科技支撑计划(2012BAI29B06); 北京中医药大学科研创新团队资助项目(2011-CXTD-12); 北京中医药大学重点学科开放课题(2013-2DXKKF-23) 作者简介:孙雅姝(1989- ),女,2012级在读硕士研究生。研究方向:中药(复方)有效物质基础研究与药物创新。E-mail:syscool0526@126.com 通讯作者:石任兵(1957- ),博士,教授,博士生导师。研究方向:中药(复方)有效物质基础研究与药物创新。E-mail:shirb@126.c
更新日期/Last Update: 2015-03-20