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[1]李鳌,陆文秀,赵璐,等.晚期胃肠道肿瘤正虚程度与外周血肿瘤缺氧相关蛋白关系[J].环球中医药,2015,8(03):295-298.[doi:10.3969/j.issn.1674-1749.2015.03.008]
　LI Ao,LU Wen-xiu,ZHAO Lu,et al.Relationship of healthy Qi deficiency and serum hypoxia-related proteins in patients with advanced gastrointestinal cancer[J].,2015,8(03):295-298.[doi:10.3969/j.issn.1674-1749.2015.03.008]
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晚期胃肠道肿瘤正虚程度与外周血肿瘤缺氧相关蛋白关系()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年03期
页码:
295-298
栏目:
论著
出版日期:
2015-03-06

文章信息/Info

Title:
Relationship of healthy Qi deficiency and serum hypoxia-related proteins in patients with advanced gastrointestinal cancer
作者:
李鳌; 陆文秀; 赵璐; 袁旭; 张勇; 张强; 朱晏伟; 孙珏; 范忠泽; 许建华
200062上海中医药大学附属普陀医院肿瘤科 上海中医药大学中西医结合肿瘤介入研究所[李鳌、赵璐(博士研究生)、陆文秀(硕士研究生)、袁旭、张勇、张强、朱晏伟、孙珏、范忠泽、许建华]
Author(s):
LI Ao;  LU Wen-xiu;  ZHAO Lu;  et al.
Oncology Department Putuo Hospital& Interventional Oncology Institute of Integrative Medicine, Shanghai University of TCM, Shanghai 200062,China Corresponding author: XU Jian-hua, E-mail: xujianhua50@126.com
关键词:
胃肠道肿瘤;  正虚;  缺氧相关蛋白;  血管内皮生长因子;  骨桥蛋白;  碳酸酐酶IX
Keywords:
Gastrointestinal cancer;  Healthy Qi deficiency;  Hypoxia-related proteins;  Vascular endothelial growth factor;  Osteopontin;  Carbonic anhydrase IX
分类号:
R735.2
DOI:
10.3969/j.issn.1674-1749.2015.03.008
文献标志码:
A
摘要:
目的 探讨晚期胃肠道肿瘤正虚程度与外周血肿瘤缺氧相关蛋白之间的关系。方法 普陀医院肿瘤科2012年4月1日到2013年4月10日IV期胃肠道肿瘤患者46例,以卡氏(Karnofsky Performance Status, KPS)评分、中医症候(气短、纳差、爪甲不荣)作为评价患者正虚指标,并根据正虚指标分别分组,采用酶联免疫吸附法检测患者血清中血管内皮生长因子(vascular endothelial growth factor, VEGF)、骨桥蛋白(osteopontin, OPN)、碳酸酐酶IX(carbonic anhydrase IX, CAIX)水平。 结果 经成组t检验,晚期胃肠道肿瘤患者KPS≤60分组与KPS>60分组比较,前者VEGF、OPN、CAIX水平分别是后者的1.75倍(P<0.05)、1.10倍(P>0.05)、1.68倍(P<0.05)。晚期胃肠道肿瘤具有气短、纳差、爪甲不荣症状患者外周血VEGF、OPN、CAIX水平均明显高于无上述症状患者(爪甲不荣组CAIX除外),其中以VEGF指标均有统计学意义(P<0.05)。结论 晚期胃肠道肿瘤正虚程度与外周血缺氧相关蛋白VEGF、OPN、CAIX相关。
Abstract:
Objective To investigate the relationship between the extent of healthy Qi deficiency and hypoxia-related proteins in the advanced gastrointestinal cancer patients.Methods We recruited 46 patients with stage IV advanced gastrointestinal cancer between April 1, 2012 and April 10, 2013. The KPS score and TCM symptoms(shortness of breath, poor appetite, matt fingernail)for evaluating patients were determined for evaluatingpatients with healthy Qi deficiency and setting groups ELISA test were performed to examine the expression level of vascular endothelial growth factor(VEGF), osteopontin(OPN)and carbonic anhydrase IX(CAIX). Results After a group t test, compared advanced gastrointestinal cancer patients KPS≤60 group with KPS>60 group, the former of VEGF, OPN, CAIX respectively was 1.75 times(P<0.05),1.10 times(P>0.05),1.68(P<0.05)that of the latter. Advanced gastrointestinal cancer have the symptoms of shortness of breath, poor appetite, matt fingernail in patients with VEGF, OPN, CAIX levels were significantly higher than those without these symptoms(except CAIX in matt fingernail group), which VEGF were statistically significant(P<0.05). Conclusion The expression of hypoxia-related proteins increased gradually with the healthy Qi deficiency degree in the advanced gastrointestinal cancer patients.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金面上项目(81073105,81273733); 上海市普陀区自主创新项目 作者简介:李鳌(1984- ),2012级在读博士研究生。研究方向:中医药治疗胃肠道肿瘤临床与实验研究。E-mail:wo-shi-li-ao@126.com 通讯作者:许建华(1962- ),博士,主任医师,博士生导师。研究方向:中医药治疗胃肠道肿瘤临床与实验研究。E-mail:xujianhua50@126.com
更新日期/Last Update: 2015-03-20