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[1]吴爱明,赵明镜,张冬梅,等.高血压病患者血清白介素6对缺血性中风诊断和辨证的临床意义探讨[J].环球中医药,2015,8(04):399-402.[doi:10.3969/j.issn.1674-1749.2015.04.004]
　WU Ai-ming,ZHAO Ming-jing,ZHANG Dong-mei,et al.Discussion on the clinical value of serum interleukin- 6 for the diagnosis and syndrome differentiation of ischemic stroke in patients with hypertension[J].,2015,8(04):399-402.[doi:10.3969/j.issn.1674-1749.2015.04.004]
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高血压病患者血清白介素6对缺血性中风诊断和辨证的临床意义探讨()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年04期
页码:
399-402
栏目:
论著
出版日期:
2015-04-06

文章信息/Info

Title:
Discussion on the clinical value of serum interleukin- 6 for the diagnosis and syndrome differentiation of ischemic stroke in patients with hypertension
作者:
吴爱明; 赵明镜; 张冬梅; 高永红; 孙逸坤; 聂波; 娄利霞; 王硕仁
作者单位:100700 北京中医药大学东直门医院中医内科学教育部和北京市重点实验室[吴爱明(博士研究生)、赵明镜、张冬梅、高永红、孙逸坤、聂波、娄利霞、王硕仁]
Author(s):
WU Ai-ming;  ZHAO Ming-jing;  ZHANG Dong-mei;  et al.
Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China Corresponding author: WANG Shuo-ren, E-mail: doctor_wang@sohu.com
关键词:
高血压病;  白介素6;  缺血性中风;  中医证候
Keywords:
Hypertension;  Interleukin- 6;  Ischemic stroke;  Traditional Chinese Medicine syndromes
分类号:
R259
DOI:
10.3969/j.issn.1674-1749.2015.04.004
文献标志码:
A
摘要:
目的 探讨高血压病患者血清白介素6(interleukin- 6, IL- 6)检测对辅助缺血性中风诊断和辨证的临床意义。方法 检测189例原发性高血压病患者的血清IL- 6浓度。比较合并和未合并缺血性中风两个亚组的IL- 6浓度差异,运用受试者工作特征曲线(receiver operating characteristic curve, ROC)评价IL- 6对辅助缺血性中风诊断的临床意义。分析不同IL- 6浓度下的中医证候差异,并通过相关分析来探讨IL- 6与中医证候之间的关系。结果 高血压合并缺血性中风组的血清IL- 6浓度[中位数(25%位数,75%位数)]显著高于未合并中风组[21.47(5.52,45.44)vs 2.92(1.68,4.67)pg/mL,P<0.01]。高血压病患者血清IL- 6诊断缺血性中风的ROC曲线下面积为0.784(P<0.01),最佳临界值为10.10 pg/mL,对应的敏感度为72.1%,特异度为88.4%。与IL- 6低浓度组比较,IL- 6高浓度组的痰证出现率高,虚证出现率低(P<0.01)。相关分析显示,血清IL- 6与痰证之间存在正相关关系(r=0.404,P<0.01)。结论 高血压病患者血清IL- 6浓度对辅助缺血性中风诊断和痰证辨证具有一定参考意义。
Abstract:
Objective To observe the clinical value of detecting serum interleukin- 6(IL- 6)for the diagnosis and syndrome differentiation of ischemic stroke in patients with hypertension. Methods The concentrations of serum IL- 6 in 189 cases of patients with essential hypertension were detected. The differences in IL- 6 concentration were compared between the hypertension group complicated with ischemic stroke and the hypertension group without ischemic stroke. The clinical value of serum IL- 6 for the diagnosis of ischemic stroke was determined by using the receiver operating characteristic(ROC)curves. Then the differences in Traditional Chinese Medicine(TCM)syndromes under different levels of concentrations of IL- 6 were analyzed, and based on the analysis, the correlation between IL- 6 and TCM syndromes were further explored. Results Compared with the hypertension group without ischemic stroke, the concentration of serum IL- 6 [Median(25th percentile, 75th percentile)] was significantly higher in the hypertension group complicated with ischemic stroke [21.47(5.52, 45.44)vs 2.92(1.68, 4.67)pg/mL, P<0.01]. The area under ROC curves in the diagnosis of ischemic stroke in patients with hypertension by means of serum IL- 6 was 0.784(P<0.01). The optimal cut-off point of IL- 6 was 10.10 pg / mL, with a corresponding sensitivityof 72.1% and specificity of 88.4%. Compared with the low IL- 6 concentration group, the probability of occurrence of phlegm syndrome increased and the probability of occurrence of deficiency syndrome decreased in the high IL- 6 concentration group(P<0.01). Furthermore the correlation analysis showed that there was a positive correlation between IL- 6 and phlegm syndrome(r=0.404, P<0.01). Conclusion Serum IL- 6 has some reference value in the diagnosis of ischemic stroke and can assist TCM in the differentiation of phlegm syndrome in patients with hypertension.

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备注/Memo

备注/Memo:
基金项目:国家重点基础研究发展计划(973计划)(2006CB504805) 作者简介:吴爱明(1979- ),2014级在读博士研究生,副研究员。研究方向:中西医结合心脑血管病研究。E-mail:wam688@163.com 通讯作者:王硕仁(1947- ),本科,主任医师,研究员,博士生导师。研究方向:中西医结合临床和应用基础研究。E-mail:doctor_wang@sohu.com
更新日期/Last Update: 2015-04-20