|本期目录/Table of Contents|

[1]孙冬生,王珠梅,金俊杰,等.百合知母汤配伍机理的红外光谱研究[J].环球中医药,2015,8(04):423-427.[doi:10.3969/j.issn.1674-1749.2015.04.010]
　SUN Dong-sheng,WANG Zhu-mei,JIN Jun-jie,et al.Infrared spectra research on compatibility mechanism of Baihe Zhimu Decoction[J].,2015,8(04):423-427.[doi:10.3969/j.issn.1674-1749.2015.04.010]
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百合知母汤配伍机理的红外光谱研究()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年04期
页码:
423-427
栏目:
论著
出版日期:
2015-04-06

文章信息/Info

Title:
Infrared spectra research on compatibility mechanism of Baihe Zhimu Decoction
作者:
孙冬生; 王珠梅; 金俊杰; 迟宗良; 陈丹妮; 秦昆明
作者单位:225300 泰州市中医院药学部(孙冬生、王珠梅); 南京中医药大学 国家教育部中药炮制规范化及标准化工程研究中心(陈丹妮、秦昆明); 江苏海昇药业有限公司研发中心(金俊杰、迟宗良、秦昆明); 南京海源中药饮片有限公司研发中心(金俊杰、迟宗良、秦昆明)
Author(s):
SUN Dong-sheng; WANG Zhu-mei; JIN Jun-jie; et al.
Department of Pharmacy Taizhou Hospital of Traditional Chinese Medicine,Taizhou 225300,China Corresponding author:QIN Kun-ming,E-mail:qinkm123@126.com
关键词:
红外光谱;  百合知母汤;  百合;  知母
Keywords:
Infrared spectroscopy;  Baihe Zhimu Decoction;  Bulbus Lilii;  Rhizoma Anemarrhenae
分类号:
R284
DOI:
10.3969/j.issn.1674-1749.2015.04.010
文献标志码:
A
摘要:
目的 利用傅里叶变换红外光谱技术对百合知母汤及其组方药味进行了研究。方法 实验测试了单味药百合、知母及百合知母汤剂的红外光谱。结果 在百合知母汤剂中保留了百合、知母单味药汤剂中的某些吸收峰,如百合知母汤光谱2933 cm-1和1059 cm-1处等; 百合、知母单味药光谱中的某些吸收峰并未在百合知母汤光谱中出现,如百合光谱1724 cm-1和知母光谱1453 cm-1等; 在百合知母汤剂光谱中出现了新的吸收峰,如百合知母汤光谱1871 cm-1和1522 cm-1处等。同时,因吸收峰位置的改变,说明各基团在百合、知母和百合知母汤中所处的化学环境不同或汤剂中化学物质的结构发生了变化。结论 百合知母汤及其组方药味的红外谱图特征具有一定的变化规律,根据对特征峰的指认和归属,可初步揭示百合知母汤及其组方药味的红外光谱差异; 单味药的特征峰在百合知母汤中得到较好的显示,该方法可以用于百合知母汤的宏观质量控制,也为探索方剂的配伍规律提供了新思路。
Abstract:
Objective The change in the mixed decoction was discussed to study the relationship between Bulbus Lilii and Rhizoma Anemarrhenae after decoction. Methods The fourier transform infrared spectra(FTIR)of Bulbus Lilii decoction, Rhizoma Anemarrhenae decoction and Baihe Zhimu Decoction were tested. Results showed that some components of Bulbus Lilii and Rhizoma Anemarrhenae were retained in the mixed decoction of Baihe Zhimu Decoction, such as 2933 and 1059 cm-1, but some components that never appeared in the two component spectra increased, such as 1724 cm-1 in Bulbus Lilii and 1453 cm-1 in Rhizoma Anemarrhenae. New absorption peaks were generated in the mixed decoction of BZT, such as 1871 and 1522 cm-1. It can be showed that there are differences in the chemistry environment of the various chemical groups in the Baihe Zhimu Decoction, and with the variation in absorption peak position, possibly some new chemical constituents were created. Pharmaceutical effective substances in the Baihe Zhimu Decoction are not simply the addition of Bulbus Lilii and Rhizoma Anemarrhenae. Conclusion This method can be used in the quiality control of BZT and proposed a new method in the compatibility research of traditional Chinese medicinal formulas.

参考文献/References:

[1] 周俊.中药复方-天然组合化学库与多靶作用机理[J].中国中西医结合杂志,1998,18(2): 67.
[2]李燕,吴然然,于佰华,等. 红外光谱在中药定性定量分析中的应用[J].光谱学与光谱分析,2006,26(10):1846-1849.
[3]徐荣,孙素琴,刘友刚,等. 红外光谱法对肉苁蓉径向不同部位的分析与评价[J]. 分析化学,2009,37(2):221-226.
[4]刘红霞,孙素琴,杨峻山.现代红外光谱技术用于复方四逆汤的配伍研究[J].光谱学与光谱分析,2007,27(7):1316-1318.
[5]武彦文,孙素琴,肖小河,等.黄连-吴茱萸药对不同配伍方式的红外光谱研究[J].光谱学与光谱分析,2009,29(7):1797-1800.
[6]郑水庆. 百合知母汤抗抑郁作用的理论与实验研究[D]. 上海: 第二军医大学,2007.
[7]张颖,赵腾斐,高钦,等. 百合知母汤对围绝经期肾虚证大鼠体征及下丘脑单胺类神经递质的影响[J].南京中医药大学学报,2009,25(3):184-186.
[8]王华富,蔡宝昌,高钦,等. 百合知母汤对自然衰老型围绝经期综合征肾虚证大鼠中枢神经递质含量的影响[J].江西中医学院学报,2009,21(3):53-55.
[9]秦昆明,方前波,蔡皓,等. 百合知母汤高效液相色谱指纹图谱研究及其与组方药味的相关性分析[J].色谱,2009,27(6):781-786.
[10]秦昆明,方前波,蔡皓,等.百合知母汤及其组方药味的高效液相色谱-电喷雾质谱研究[J].分析化学,2009,37(12):1759-1764.
[11]方前波,秦昆明,潘扬,等.百合知母汤的化学成分研究[J].中草药,2010,41(4):517-321.
[12]秦昆明,方前波,蔡宝昌. 指纹图谱技术在方剂现代研究中的应用现状[J]. 世界科学技术-中医药现代化,2009,11(2):287-293.
[13]Shimomura H,Sashida Y,Mimaki Y,et al. New phenylpropanoid glycerol glucosides from the bulbs of Lilium species[J]. Chem Pharm Bull,1988,36(12):4841- 4848.
[14]Shimomura H,Sashida Y,Mimaki Y. New phenolic glycerol glucosides,regaloside D,E, and F from the bulbs of Lilium Species[J]. Shoyakugaku Zasshi,1989,43(1):64-70.
[15]Hong YF,Han GY,Guo XM. Isolation and structure determination of xantone glycosides of . Acta Pharmaceutica Sinica,1997,(32):473- 475.
[16]倪梁红,秦民坚. 知母资源化学及药理研究进展[J].中国野生植物资源,2005,24(4):16-20.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(90709025); 江苏省科技支撑计划(BE2012011); 江苏省自然科学基金(BK2011135) 作者简介:孙冬生(1971- ),本科,主管中药师。研究方向:中药质量控制及药物分析。E-mail:1272813260@qq.com 通讯作者:秦昆明(1985- ),2012级在读博士研究生,助理研究员。研究方向:主要从事中药质量标准研究。E-mail:qinkm123@126.com
更新日期/Last Update: 2015-04-20