|本期目录/Table of Contents|

[1]朱迪娜,辛文锋,张文生.栀子苷治疗糖尿病及其并发症的分子机制研究进展[J].环球中医药,2015,8(05):624-628.[doi:10.3969/j.issn.16741749.2015.05.035]
　ZHU Di na,XIN Wen feng,ZHANG Wen sheng..Research progress on the molecular mechanism of geniposide for diabetes and its complications treatment[J].,2015,8(05):624-628.[doi:10.3969/j.issn.16741749.2015.05.035]
点击复制

栀子苷治疗糖尿病及其并发症的分子机制研究进展()
     
分享到：

《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年05期
页码:
624-628
栏目:
综述
出版日期:
2015-05-06

文章信息/Info

Title:
Research progress on the molecular mechanism of geniposide for diabetes and its complications treatment
作者:
朱迪娜; 辛文锋; 张文生
100875 北京师范大学中药资源保护与利用北京市重点实验室
Author(s):
ZHU Dina;  XIN Wenfeng;  ZHANG Wensheng.
Protection and Utilization of Chinese Medicine Resources of Beijing Key Laboratory， Beijing Normal University, Beijing 100875, China Corresponding author: ZHANG Wensheng, Email: zws@bnu.edu.cn
关键词:
糖尿病; 栀子苷; 京尼平; 分子机制
Keywords:
Diabetes mellitus; Geniposide; Genipin; Molecular mechanism
分类号:
R285
DOI:
10.3969/j.issn.16741749.2015.05.035
文献标志码:
A
摘要:
糖尿病是一种以慢性高血糖为特征的代谢性疾病，可引起多种并发症，主要表现在全身微循环的障碍，如肾、眼、心血管及神经等慢性损伤。栀子苷是栀子的主要有效成分，其水解苷元为京尼平。有研究报道，栀子苷具有降低血糖，改善糖尿病并发症病理变化的作用，有望成为糖尿病治疗的潜在药物。本文对近年来栀子苷和京尼平治疗糖尿病的相关研究进行总结，以期为深入研究其治疗糖尿病的分子机制提供思路。
Abstract:
Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia. Untreated, diabetes can cause many complications. It mainly reflects in systemic microcirculation disorder, including kidney, eyes, cardiovascular system and nerves damage. Geniposide is the main effective components of traditional Chinese medicine Gardenia jasminoides Ellis，and its hydrolysed aglycon is genipin．Pharmacological studies showed that geniposide and genipin could result in blood glucose decrease, treat diabetic complication and be expected to become the new drugs for the treatment of diabetes mellitus. This review summarizes studies of geniposide and genipin for diabetes therapy recently, in order to further research on the molecular mechanism for the treatment of diabetes.

参考文献/References:

[1]Boussageon R, BejanAngoulvant T, SaadatianElahi M, et al. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: metaanalysis of randomised controlled trials[J]. BMJ, 2011,343:d4169.
[2]Krein S L, Bernstein S J, Fletcher C E, et al. Improving eye care for veterans with diabetes: an example of using the QUERI steps to move from evidence to implementation: QUERI Series[J]. Implement Sci, 2008,(3):18.
[3]S R J, SaRoriz T M, Rosset I, et al. (Pre)diabetes, brain aging, and cognition[J]. Biochim Biophys Acta, 2009,1792(5):432443.
[4]Shaw J E, Sicree R A, Zimmet P Z. Global estimates of the prevalence of diabetes for 2010 and 2030[J]. Diabetes Res Clin Pract, 2010,87(1):414.
[5]中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2010年版)[J]. 中国医学前沿杂志（电子版）, 2011,3(6):54109.
[6]Shieh J P, Cheng K C, Chung H H, et al. Plasma glucose lowering mechanisms of catalpol, an active principle from roots of Rehmannia glutinosa, in streptozotocininduced diabetic rats[J]. J Agric Food Chem, 2011,59(8):37473753.
[7]Kim H L, Jeon Y D, Park J, et al. Corni Fructus Containing Formulation Attenuates Weight Gain in Mice with DietInduced Obesity and Regulates Adipogenesis through AMPK[J]. Evid Based Complement Alternat Med, 2013,2013:423741.
[8]Yamabe N, Kang K S, Matsuo Y, et al. Identification of antidiabetic effect of iridoid glycosides and low molecular weight polyphenol fractions of Corni Fructus, a constituent of Hachimijiogan, in streptozotocininduced diabetic rats[J]. Biol Pharm Bull, 2007,30(7):12891296.
[9]杨春辉, 马莉, 魏振平. 环烯醚萜类化合物在防治糖尿病方面研究进展[J]. 化学工业与工程, 2011,28(6):6873.
[10]王磊, 辛文锋, 张文生. 栀子苷治疗阿尔采末病及神经保护的分子机制研究进展[J]. 中国药理学通报, 2012,28(5):604607.
[11]颜静恩, 李晚忱, 吕秋军, 等. 栀子苷的降糖作用和对PPARγ受体的激活[J]. 四川农业大学学报, 2007,25(4):415418.
[12]Wu S Y, Wang G F, Liu Z Q, et al. Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a highfat diet and streptozotocin[J]. Acta Pharmacol Sin, 2009,30(2):202208.
[13]Liu H T, He J L, Li W M, et al. Geniposide inhibits interleukin6 and interleukin8 production in lipopolysaccharideinduced human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways[J]. Inflamm Res, 2010,59(6):451461.
[14]Deng Y, Guan M, Xie X, et al. Geniposide inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma[J]. Int Immunopharmacol, 2013,17(3):561567.
[15]Suzuki Y, Kondo K, Ikeda Y, et al. Antithrombotic effect of geniposide and genipin in the mouse thrombosis model[J]. Planta Med, 2001,67(9):807810.
[16]Kimura Y, Okuda H, Arichi S. Effects of geniposide isolated from Gardenia jasminoides on metabolic alterations in high sugar dietfed rats[J]. Chem Pharm Bull (Tokyo), 1982,30(12):44444447.
[17]Mulholland D J, Dedhar S, Coetzee G A, et al. Interaction of nuclear receptors with the Wnt/betacatenin/Tcf signaling axis: Wnt you like to know[J]. Endocr Rev, 2005,26(7):898915.
[18]Prestwich T C, Macdougald O A. Wnt/betacatenin signaling in adipogenesis and metabolism[J]. Curr Opin Cell Biol, 2007,19(6):612617.
[19]Welters H J, Kulkarni R N. Wnt signaling: relevance to betacell biology and diabetes[J]. Trends Endocrinol Metab, 2008,19(10):349355.
[20]RobsonDoucette C A, Sultan S, Allister E M, et al. Betacell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion[J]. Diabetes, 2011,60(11):27102719.
[21]Zhang C Y, Parton L E, Ye C P, et al. Genipin inhibits UCP2mediated proton leak and acutely reverses obesity and high glucoseinduced beta cell dysfunction in isolated pancreatic islets[J]. Cell Metab, 2006,3(6):417427.
[22]Liu J, Guo L, Yin F, et al. Geniposide Regulates GlucoseStimulated Insulin Secretion Possibly through Controlling Glucose Metabolism in INS1 Cells[J]. PLoS One, 2013,8(10):e78315.
[23]Liu J, Yin F, Xiao H, et al. Glucagonlike peptide 1 receptor plays an essential role in geniposide attenuating lipotoxicityinduced betacell apoptosis[J]. Toxicol In Vitro, 2012,26(7):10931097.
[24]Xu J, Zou M H. Molecular insights and therapeutic targets for diabetic endothelial dysfunction[J]. Circulation, 2009,120(13):12661286.
[25]Koo H J, Song Y S, Kim H J, et al. Antiinflammatory effects of genipin, an active principle of gardenia[J]. Eur J Pharmacol, 2004,495(23):201208.
[26]Wang G F, Wu S Y, Xu W, et al. Geniposide inhibits high glucoseinduced cell adhesion through the NFkappaB signaling pathway in human umbilical vein endothelial cells[J]. Acta Pharmacol Sin, 2010,31(8):953962.
[27]费曜, 朱丹平, 刘凡, 等. 栀子对 STZ 诱导的 2 型糖尿病大鼠血糖及血脂的影响[J]. 中药药理与临床, 2011,27(6):4952.
[28]Hotamisligil G S, Shargill N S, Spiegelman B M. Adipose expression of tumor necrosis factoralpha: direct role in obesitylinked insulin resistance[J]. Science, 1993,259(5091):8791.
[29]Pickup J C, Crook M A. Is type II diabetes mellitus a disease of the innate immune system[J]. Diabetologia, 1998,41(10):12411248.
[30]Duncan B B, Schmidt M I, Pankow J S, et al. Lowgrade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study[J]. Diabetes, 2003,52(7):17991805.
[31]方尚玲, 刘源才, 张庆华, 等. 栀子苷镇痛和抗炎作用的研究[J]. 时珍国医国药, 2008,19(6):13741376.
[32]姚全胜, 周国林. 栀子抗炎,治疗软组织损伤有效部位的筛选研究[J]. 中国中药杂志, 1991,16(8):489493.
[33]Nam K N, Choi Y S, Jung H J, et al. Genipin inhibits the inflammatory response of rat brain microglial cells[J]. Int Immunopharmacol, 2010,10(4):493499.
[34]Zhang G, He J L, Xie X Y, et al. LPSinduced iNOS expression in N9 microglial cells is suppressed by geniposide via ERK, p38 and nuclear factorkappaB signaling pathways[J]. Int J Mol Med, 2012,30(3):561568.
[35]Wang J, Hou J, Zhang P, et al. Geniposide reduces inflammatory responses of oxygenglucose deprived rat microglial cells via inhibition of the TLR4 signaling pathway[J]. Neurochem Res, 2012,37(10):22352248.
[36]Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease The common soil hypothesis revisited[J]. Arterioscler Thromb Vasc Biol, 2004,24(5):816823.
[37]丁嵩涛, 刘洪涛, 李文明, 等. 栀子苷对氧化应激损伤血管内皮细胞的保护作用[J]. 中国药理学通报, 2009,25(6):725729.
[38]苏伟, 赵利, 刘建涛, 等. 栀子总皂苷抗氧化能力的研究[J]. 食品科学, 2009，30(15):7577.
[39]Kuo W H, Chou F P, Young S C, et al. Geniposide activates GSH Stransferase by the induction of GST M1 and GST M2 subunits involving the transcription and phosphorylation of MEK1 signaling in rat hepatocytes[J]. Toxicol Appl Pharmacol, 2005,208(2):155162.
[40]Liu J, Yin F, Zheng X, et al. Geniposide, a novel agonist for GLP1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway[J]. Neurochem Int, 2007,51(67):361369.
[41]袁俊芳, 赵明. 糖尿病血管内皮祖细胞活性氧和钙离子浓度的改变及栀子苷的保护作用[J]. 医学临床研究, 2011,28(12):22452248.
[42]李青岭, 于超, 李春莉, 等. 栀子苷抗H2O2诱导人脐静脉内皮细胞凋亡的实验研究[J]. 中国药理学通报, 2010,26(10):13671371.

相似文献/References:

[1]李君玲,田佳星.糖尿病胃轻瘫中医病机及分型的研究进展[J].环球中医药,2013,6(03):222.
　LI Jun ling,TIAN Jia xing..Research progress of TMC pathogenesis and syndrome types for diabetic gastroparesis[J].,2013,6(05):222.
[2]赵锡艳,王松,刘阳,等.仝小林教授治疗2型糖尿病合并围绝经期综合征辨治思路[J].环球中医药,2013,6(08):622.
[3]赵天才,杨景锋,任艳芸,等.抵当芪桂汤对STZ诱导糖尿病大鼠血浆TXB_2和血小板表面CD62_P、CD63的影响[J].环球中医药,2013,6(09):658.
　ZHAO Tian cai,YANG Jing feng,REN Yan yun,et al.Effects of Didang Qigui Decoction on blood plasma TXB2 and platelet surface CD62P/ CD63 in STZinduced diabetes rats[J].,2013,6(05):658.
[4]黄宇新,林勇凯,梁桂洪,等.柴胡桂枝干姜汤治疗糖尿病体会1则[J].环球中医药,2013,6(09):675.
[5]周艳霞,刘璐,亓鲁光,等.中药内服外洗治疗2型糖尿病合并银屑病1例[J].环球中医药,2013,6(12):918.
[6]白瑞娜,郗瑞席,李立志,等.冠心病合并糖尿病的中医研究进展[J].环球中医药,2014,7(05):389.
　BAI Rui na,XI Rui xi,LI Li zhi..Researches of coronary heart disease complicated with diabetes mellitus: a review of recent progress in the domain of Chinese medicine[J].,2014,7(05):389.
[7]王军,徐阳,矫浩然,等.糖尿病大血管纤维化探析及活血化瘀中药干预机制[J].环球中医药,2012,5(11):819.
[8]巩璇 马建伟.治疗糖尿病并发症验案举隅[J].环球中医药,2014,7(06):481.
[9]杨立波 王保群 杨洪乐等.通心络胶囊对2型糖尿病勃起功能障碍性激素及血管内皮功能的影响[J].环球中医药,2014,7(08):632.
[10]顾成娟,王涵,何莉莎.仝小林教授治疗糖尿病合并泌尿系感染的经验[J].环球中医药,2015,8(09):1108.[doi:10.3969/j.issn.1674-1749.2015.09.021]

备注/Memo

备注/Memo:
基金项目： 国家自然科学基金（81274118,81230010）；国家科技重大专项重大新药创制专项（2012ZX09103201） 作者单位：100875 北京师范大学中药资源保护与利用北京市重点实验室［朱迪娜（博士研究生）、张文生］；北京师范大学教育部天然药物工程研究中心［朱迪娜（博士研究生）、张文生］；云南省三七生物技术与制药工程研究中心（辛文锋、张文生） 作者简介：朱迪娜（1985- ），女，2012级在读博士研究生。研究方向：神经退行性疾病分子机制及神经药理学。Email：zhudina1011@163.com 通讯作者：张文生（1966- ），博士，教授，博士生导师。研究方向：神经退行性疾病分子机制及神经药理学。Email: zws@bnu.edu.cn
更新日期/Last Update: 1900-01-01