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[1]刘晶 李峰 唐旭东 马捷 葛东宇 李根茂 刘燕 刘艳阳 韩晨霞 吴卓耘.功能性消化不良脾虚证动物模型的制作及评价[J].环球中医药,2015,8(06):701-705.[doi:A doi:10.3969/j.issn.1674-1749.2015.06.015]
　LIU Jing,LI Feng,TANG Xu-dong,et al.Reconstruction and assessment of functional dyspepsia with spleen deficiency in TCM[J].,2015,8(06):701-705.[doi:A doi:10.3969/j.issn.1674-1749.2015.06.015]
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功能性消化不良脾虚证动物模型的制作及评价()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年06期
页码:
701-705
栏目:
论著
出版日期:
2015-06-06

文章信息/Info

Title:
Reconstruction and assessment of functional dyspepsia with spleen deficiency in TCM
作者:
刘晶 李峰 唐旭东 马捷 葛东宇 李根茂 刘燕 刘艳阳 韩晨霞 吴卓耘
北京中医药大学基础医学院[刘晶(博士研究生)、李峰、马捷、葛东宇、李根茂、刘燕、刘艳阳(硕士研究生)、韩晨霞(博士研究生)、吴卓耘(硕士研究生)]; 中国中医科学院西苑医院消化内科(唐旭东)
Author(s):
LIU Jing;  LI Feng;  TANG Xu-dong;  et al.
School of Basic Medical Sciences, Beijing University of Chinese Medicine,Beijing 100029,China
关键词:
功能性消化不良;  脾虚证;  动物模型
Keywords:
Functional dyspepsia;  Spleen deficiency in TCM;  Animal model
分类号:
R-332
DOI:
A doi:10.3969/j.issn.1674-1749.2015.06.015
文献标志码:
A
摘要:
目的 复制并评价功能性消化不良脾虚证动物模型。方法 运用碘乙酰胺复合小平台劳倦因素造模法,制作功能性消化不良脾虚证动物模型,并观察动物一般状态、体重、饮食情况及胃病理改变,运用糖水偏好试验,球囊试验对功能性消化不良脾虚证进行评价。结果 碘乙酰胺及复合小平台大鼠,均出现饮食减少,糖水偏好降低,胃敏感性增高。但碘乙酰胺复合小平台组大鼠体重下降明显,并伴有倦怠等精神症状。结论 模型符合功能性消化不良脾虚证标准,但碘乙酰胺复合小平台组脾虚证表征更加明显。
Abstract:
Objective Reconstruction and assessment of animal model of function dyspepsia with spleen deficiency in TCM. Methods Animal model was reconstructed by transient neonatal gastric irritation with iodoacetamide(IA)oral gavages and modified multiple platform method. Appearance, body weight, quantity of food and water in-take, sucrose preference, and gastric hypersensitivity were observed to assess whether it is the model of functional dyspepsia with spleen deficiency. Results The IA and IA with modified multiple platform method models all had less food and water in-take, low sucrose preference, and gastric hypersensitivity. The rats of IA with modified multiple platform method got lower body weight and more fatigue. Conclusion Both models met the standards of functional dyspepsia with spleen deficiency, however, IA with modified multiple platform method model appeared more spleen deficiency-like behavioral.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:刘晶(1986- ),女,2012级在读博士研究生。研究方向:“脾主运化”的现代生物学机制研究。E-mail:lglangfang@sina.com 通讯作者:李峰(1966- ),博士,教授,博士生导师。研究方向:中医“病证结合”规律研究。E-mail:lifeng95@sina.vip.com
更新日期/Last Update: 1900-01-01