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[1]董笑克 魏竞竞 杨凯 吴迪 李彤 赵丕文 牛建昭.助仙丹对多囊卵巢模型大鼠卵巢功能及形态的影响[J].环球中医药,2015,8(07):790-793.[doi: doi:10.3969/j.issn.1674-1749.2015.07.008]
　DONG Xiao-ke,WEI Jing-jing,YANG Kai,et al.Influence of Zhuxian Dan on the ovarian function and morphology of the polycystic ovary syndrome model rats[J].,2015,8(07):790-793.[doi: doi:10.3969/j.issn.1674-1749.2015.07.008]
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助仙丹对多囊卵巢模型大鼠卵巢功能及形态的影响 ()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年07期
页码:
790-793
栏目:
论著
出版日期:
2015-07-06

文章信息/Info

Title:
Influence of Zhuxian Dan on the ovarian function and morphology of the polycystic ovary syndrome model rats
作者:
董笑克 魏竞竞 杨凯 吴迪 李彤 赵丕文 牛建昭
100029 北京中医药大学第二临床医学院[董笑克(硕士研究生)、杨凯(硕士研究生)、魏竞竞(硕士研究生)、吴迪(硕士研究生)、李彤(硕士研究生)]; 北京中医药大学基础医学院(赵丕文、牛建昭)
Author(s):
DONG Xiao-ke;  WEI Jing-jing;  YANG Kai;  et al.
Beijing University of Chinese Medicine, Beijing 100029, China
关键词:
助仙丹;  多囊卵巢综合征;  高雄激素血症
Keywords:
Zhuxian Dan;  Polycystic ovary syndrome;  Hyperandrogenism
分类号:
R285.5
DOI:
doi:10.3969/j.issn.1674-1749.2015.07.008
文献标志码:
A
摘要:
目的 观察助仙丹对多囊卵巢大鼠模型卵巢形态和性激素的影响。方法 将60只大鼠随机分为2组,空白对照8只,另52只大鼠采用避孕硅胶棒联合皮下注射人绒毛膜促性腺激素方法进行造模,连续监测两个动情周期,选出造模成功大鼠30只,随机分为三组:助仙丹组(10只)、炔雌醇环丙孕酮片组(10只)、模型组(10只),称重,记为用药前大鼠体质量,助仙丹组、炔雌醇环丙孕酮片组分别给予助仙丹配方颗粒和炔雌醇环丙孕酮片灌胃,模型组及空白对照组给予等量自来水灌胃,14天后再次称重,记为用药后体质量,后腹主动脉取血,检测血清雄激素
Abstract:
Objective To investigate the effect of traditional Chinese medicine modified Zhuxian Dan(TCM-ZXD)on ovary tissues pathology and improving sex hormone in rat models of polycystic ovary syndrome(PCOS). Methods 60 rats were randomly divided into 2 groups, 52 rats in pathological model group and 8 in normal control group. Pathological model group was subcutaneous implanted of progesterone gel rod combined with HCG for building PCOS models. According to the vaginal smear, 30 successful model rats were selected and then randomly divided into three subgroups:TCM-ZXD group(10 rats), Diane-35 group(10 rats), model group(10 rats). All the rats were weighed, recorded as body weight before treatment. TCM-ZXD group and Diane-35 group were given the right amount of formula granules of TCM-ZXD and Diane-35, while the model group and the control group were given the same amount of water. After 14 days of therapy, the rats were weighed again, recorded as body weight after treatment. Blood was collected from abdominal aorta, then T in serum was determined. The weight of the ovary was recorded and ovarian morphology was observed. The results were analyzed by one-way anova. Result Compared with the model group, the added value of body weight of Diane-35 group before and after the treatment decreased significantly(P<0.05), there was a significant change in the Diane-35 group of the rats ovarian weight(P<0.05). There was no obvious difference in androgen levels in rats between these groups. According to the Ovary paraffin, TCM-ZXD group could increase the layers of ovarian granulosa cells and the number of luteal tissue, reduce the number of locked follicles.Conclusion Zhuxian Dan can improve the ovarian morphology and promote ovulation in rats with PCOS.

参考文献/References:

[1] DiamanTik E,Kouli CR,Bergiele AT,et al. A survey of the polycystic ovary syndrome in the greek island of Lesbos: hormonal and metabolic profile[J].J Clin Endocrinol Metab,1999,84(11):4006-4011. [br/] [2] 朱亮,邢福祺,全松,等.避孕硅胶棒联合HCG诱导SD大鼠多囊卵巢综合征模型的建立[J].第四军医大学学报,2009,30(6):534-536. [br/] [3] 李晓红,李红.不孕不育的病因[J].中国全科医学,2003,6(11):887-889. [br/] [4] 曹泽毅,中华妇产科学[M].北京:人民卫生出版社,1999:2177-2196. [br/] [5] Friedman JM,Leibel RL. Tackling a weighty problem[J]. Cell,1992,69(2):217-220. (收稿日期: 2014-11-11)

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备注/Memo

备注/Memo:
作者简介: 董笑克(1992- ),女,2010级七年制硕士研究生。研究方向:中医科研。E-mail:15210977893@163.com 通讯作者: 赵丕文(1967- ),女,博士,教授。研究方向:妇科中药的作用机理。E-mail:pwzhao@sina.com
更新日期/Last Update: 1900-01-01