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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:

第8卷

期数:

2015年07期

页码:

803-806

栏目:

论著

出版日期:

2015-07-06

文章信息/Info

Title:

Double-blind and placebo-controlled trial of Ziyuan Jiangya Decoction for treatment of isolated systolic hypertension

作者:

赵俊男 高洪春 鲁卫星

100029 北京中医药大学第三临床学院[赵俊男(博士研究生)]; 山东省中医院心内科(高洪春); 北京中医药大学第三附属医院心内科(鲁卫星)

Author(s):

ZHAO Jun-nan;  GAO Hong-chun;  LU Wei-xing.

The Third Clinical College, Beijing University of Chinese Medicine, Beijing 100029, China

关键词:

老年;  单纯收缩期高血压病;  气血亏虚;  临床疗效;  双盲;  安慰剂

Keywords:

Elderly;  Isolated systolic hypertension;  Qi and blood deficiency;  Clinical efficacy;  Double-blind;  Placebo

分类号:

R544.1

DOI:

doi:10.3969/j.issn.1674-1749.2015.07.011

文献标志码:

A

摘要:

目的 观察滋源降压饮对气血亏虚型老年单纯收缩期高血压病的临床疗效。方法 临床选择符合纳入标准的老年单纯收缩期高血压病患者60例,并将患者随机分为两组,每组各30例。治疗组给予滋源降压饮早晚各1次,同时晨起口服苯磺酸氨氯地平5 mg+氢氯噻嗪12.5 mg,每天1次,对照组给予安慰剂早晚各1次,同时晨起口服苯磺酸氨氯地平5 mg+氢氯噻嗪12.5 mg,每天1次,治疗前后分别观察患者的偶测血压、24小时动态血压、中医单项症状的变化情况并分别计算血压平滑指数。结果 与对照组相比,治疗组在偶测血压疗效上,无显

Abstract:

R544.1 【文献标识码】 A doi:10.3969/j.issn.1674-1749.2015.07.011 Double-blind and placebo-controlled trial of Ziyuan Jiangya Decoction for treatment of isolated systolic hypertension ZHAO Jun-nan, GAO Hong-chun, LU Wei-xing. The Third Clinical College, Beijing University of Chinese Medicine, Beijing 100029, China Corresponding author: LU Wei-Xing, E-mail: weixinglu918@sina.com 【Abstract】 Objective To observe the clinical efficacy of Ziyuan Jiangya Decoction for treatment of qi and blood deficiency type of isolated systolic hypertension.Methods 60 cases of patients met the inclusion criteria were recruited and randomly divided into two groups, with 30 cases in each group.The treatment group was treated with Ziyuan Jiangya Decoction and amlodipine 5 mg + hydrochlorothiazide 12.5 mg once daily, while the control group was treated with placebo, and amlodipine 5 mg + hydrochlorothiazide 12.5 mg once daily.Before and after treatment, blood pressure, 24h ambulatory blood pressure, changes in individual symptoms of Chinese medicine were observed and blood pressure smoothness indexes were calculated.Results Compared with the control group, changes in random blood pressure and 24h ambulatory blood pressure were not significantly different in the treatment group(P>0.05).But blood pressure smoothness index was higher in the treatment group than in the control group, and both systolic and diastolic blood pressure were significantly different(P=0.007, P=0.000).For the improvement in symptoms aspects, the treatment group was superior to the control group.Comparison of the efficacy clinical symptoms, there was significantly different(P=0.002).Conclusion Ziyuan Jiangya Decoction combined with western antihypertensive medications in elderly patients with isolated systolic hypertension, can not only reduce blood pressure levels in patients, but also improve the patient's clinical symptoms.Compared with simply taking blood pressure medicine, blood pressure is more stable when taking Ziyuan Jiangya Decoction combined with western antihypertensive medications.

参考文献/References:

[1] 郑筱萸.中药新药临床研究指导原则(试行)[M].北京: 中国医药科技出版社, 2002: 57-80. [br/] [2] 陈晓光, 崔志勇.何首乌对老年小鼠衰老指标的影响[J].中草药, 1991, 22(8): 357-359. [br/] [3] 吴发宝, 陈希元.黄芪药理作用研究综述[J].中药材, 2004, 27(3): 232-234. [br/] [4] 翟文俊.杜仲叶浸提物制剂对大鼠血压及心率的影响[J].陕西教育学院学报, 2004, 20(4): 106. [br/] [5] 后藤博三[日].钩藤对自发性高血压大鼠血管内皮功能的影响[J].国外医学(中医中药分册), 2000, 22(1): 28-29. [br/] [6] 魏毅, 张贵平.白芍总苷对血小板功能的影响[J].医学理论与实践, 2004, 17(8): 871. [br/] [7] 贾绿琴, 孙秀英.中药川芎的研究进展[J].黑龙江科技信息, 2009, 13(11):146-147. [br/] [8] 王德全, 胡俊英.黄柏胶囊抗炎疗效临床分析[J].中华实用中西医杂志, 2004, 4(17): 839.

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备注/Memo

备注/Memo:

作者简介:赵俊男(1988- ),2014级在读博士研究生。研究方向:中医药防治心血管疾病的研究。E-mail: 546965578@qq.com 通讯作者:鲁卫星(1959- ),硕士,博士生导师,主任医师。研究方向:中医药防治心血管疾病的研究。E-mail: weixinglu918@sina.com

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