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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:

第8卷

期数:

2015年08期

页码:

912-915

栏目:

论著

出版日期:

2015-08-06

文章信息/Info

Title:

The Effect of Shegan Mahuang decoction on T cell functions of Asthmatics

作者:

杨硕 罗光伟 胡小萍 万军 夏倩 陈菁 袁文胜 孙洁民

430022 武汉市第一医院呼吸科

Author(s):

YANG Shuo;  LUO Guang-wei;  HU Xiao-ping;  et al.

Department of Respiratory,Wuhan No.1 Hospital,Wuhan 430022, China

关键词:

射干麻黄汤;  支气管哮喘;  T细胞亚群

Keywords:

Shegan Mahuang decoction;  Asthma;  T cell subsets

分类号:

R285.6

DOI:

doi:10.3969/j.issn.1674-1749.2015.08.005

文献标志码:

A

摘要:

目的 观察射干麻黄汤对寒哮患者外周血T细胞亚群及白细胞介素(interleukin,IL)-5、IL-10 mRNA水平的影响。方法 将51例轻中度寒哮患者按随机数字表法分为治疗组25例和对照组26例。对照组给沙丁胺醇气雾剂,每次吸入100 μg,每天4次; 治疗组在对照组的基础上加用射干麻黄汤中药配方颗粒冲服,每天1剂,早晚2次冲服。两组均治疗12周。分别于治疗前和治疗后12周留取血液行流式细胞术检测T细胞亚群,RT-PCR检测IL-5、IL-10 mRNA表达。结果 治疗后两组比较:CD³⁺、CD⁴⁺、CD⁸⁺无显著差异,CD4/CD8比值(t=2.593,P=0.012)、IL-5(t=2.492,P=0.016)明显下降,IL-10(t=2.659,P=0.011)明显上升。结论 射干麻黄汤调节哮喘患者T细胞CD4/CD8比例及IL-5、IL-10表达水平,改变机体细胞免疫功能,控制哮喘症状。

Abstract:

Objective To observe the effects of Shegan Mahuang decoction on peripheral blood T cell subsets and IL-5mRNA, IL-10mRNA expression in asthmatics. Methods 51 cases of mild to moderate asthmatics were randomly divided into treatment group(25 patients)and control group(26 patients). Control group was given salbutamol aerosol, each inhalation 100μg, four times daily; treatment group were given extra dosage of Chinese medicine(Shegan Mahuang decoction), twice a day on in the morning and evening. Both groups were treated for 12 weeks. Blood specimens were collected respectively before and after treatment. Then T cell subsets were detected by the line flow cytometry, and IL-5, IL-10mRNA expression tested by RT-PCR. Results Compared with control group, T cell subsets CD³⁺, CD⁴⁺, CD⁸⁺ showed no significant difference, but CD4/CD8 ratio(t= 2.593, P= 0.012), IL-5(t= 2.492, P= 0.016)and IL-10(t= 2.659, P= 0.011)were changed significantly. Conclusion Shegan Mahuang decoction can adjust CD4/CD8 ratio and the IL-5, IL-10 expression, regulate immune function, and control asthma symptoms.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介: 杨硕(1979- ),博士,主治医师。研究方向:肺部炎症。E-mail: yangshuo2003103@aliyun.com 通讯作者: 罗光伟( 1968- ),硕士,主任医师,硕士研究生导师。研究方向:支气管哮喘、慢性阻塞性肺疾病。E-mail: whyyy191@sina.com

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