|本期目录/Table of Contents|

[1]白雯 阎小萍 吕素飞 陶庆文 王建明 金玥 陈璐 赵超群 朱笑夏.中医药对骨关节炎动物模型细胞因子作用研究进展[J].环球中医药,2015,8(08):1018-1021.[doi: doi:10.3969/j.issn.1674-1749.2015.08.038]
　BAI Wen,YAN Xiao-ping,LV Su-fei,et al.Progress on the effects of cytokines in the animal model of osteoarthritis by traditional Chinese medicine treatment[J].,2015,8(08):1018-1021.[doi: doi:10.3969/j.issn.1674-1749.2015.08.038]
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中医药对骨关节炎动物模型细胞因子作用研究进展()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年08期
页码:
1018-1021
栏目:
综述
出版日期:
2015-08-06

文章信息/Info

Title:
Progress on the effects of cytokines in the animal model of osteoarthritis by traditional Chinese medicine treatment
作者:
白雯 阎小萍 吕素飞 陶庆文 王建明 金玥 陈璐 赵超群 朱笑夏
100029 北京中医药大学[白雯(硕士研究生)、吕素飞(硕士研究生)、金玥(硕士研究生)、陈璐(硕士研究生)、赵超群(硕士研究生)、朱笑夏(硕士研究生)]; 中日友好医院中医风湿病科(阎小萍、陶庆文、王建明)
Author(s):
BAI Wen;  YAN Xiao-ping; LV Su-fei; et al.
Beijing University of Chinses Medicine,Beijing 100029,China
关键词:
中医药;  骨关节炎;  动物模型;  细胞因子
Keywords:
Traditional Chinese medicine;  Osteoarthritis;  Animal model;  Cytokines
分类号:
R684
DOI:
doi:10.3969/j.issn.1674-1749.2015.08.038
文献标志码:
A
摘要:
骨关节炎以关节软骨及软骨下骨受累为主,目前发病机制尚不明确,细胞因子可能通过复杂的作用机制参与骨关节炎的形成。中医药能有效改善骨关节炎患者的症状及体征,具有独特优势。本文从细胞因子作用研究方面,通过对近年来中医药治疗骨关节炎动物模型的文献进行综述总结,认为中医药能够抑制白细胞介素(interleukin,IL)的形成,降低血清和关节液中肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)的水平,上调转化生长因子(transforming growth factor-β,TGF-β)的表达,提高TGF-β的水平,下调结缔组织生长因子(connective tissue growth factor,CTGF)的表达以降低CTGF介导的软骨细胞的增殖与表达,达到保护关节软骨,减缓骨关节炎骨赘的形成,减缓发病进程的目的。
Abstract:
Osteoarthritis is a chronic disease, which mainly results from the articular cartilage damage of intergrity and articular cartilage under plate of bone lesions. At present, the pathogenesis of osteoarthritis is still not clear. Cytokines may be involved in the pathogenesis through a complex mechanism. Traditional Chinese medicine has unique advantages in improving the symptoms and signs of patients with osteoarthritis. This paper reviewed the effects of cytokines in the animal model of osteoarthritis treated by Traditional Chinese medicine in recent years. It is reviewed that Traditional Chinese medicine can protect the articular cartilage, slow down osteoarthritis osteophyte formation and postpone the process of osteoarthritis by inhibiting the formation of IL(Iinterleukin), reducing the level of TNF-α(tumour necrosis factor-α)in serum and synovial fluid, increasing TGF- β(transforming growth factor-β)expression and raising the level of it, decreasing CTGF(connective tissue growth factor)expression to slow down the formation of osteophyte and the progression.

参考文献/References:

[1] 陶庆文,徐愿,王建明,等,骨痹通方治疗膝骨关节炎的临床研究[J],风湿病与关节炎,2012,4(1):11-14.
[2] Heraud F, Heraud A, Harmard MF1 Apoptosis in normal andosteourthritis human articular cartilage [ J] 1 Ann Rheum Dis,2000, 59( 12):959-996.
[3] 陈飞雁,顾湘杰,钟明康,等. 威灵仙注射液对骨关节炎关节液与软骨白介素-1的影响 [J]. 中国矫形外科杂志,2004,12(7):524-526.
[4] 张爱玲,于沛林,王晓宁,等. 补肾壮骨颗粒对兔膝骨性关节炎白介素-1和肿瘤坏死因子的影响 [J].光明中医,2010,25(3):424-426.
[5] 王秀华,刘元禄,苏姿兵,等. 丹参关节内注射对兔膝骨关节炎细胞因子IL-1 及TNF 的影响[J].中医正骨,2003,15(10):1-2.
[6] 刘英杰,马利杰,王相利,等. 独活寄生汤对兔膝骨性关节炎关节液白细胞介素- 1和肿瘤坏死因子的影响 [J].河北中医,2007,29(8):748-749.
[7] 钟玉,李荣亨,周小莉. 复元胶囊对实验性兔骨关节炎白介素1 及转化生长因子β2 的调节作用 [J]. 重庆医科大学学报,2007,32(8):856-861.
[8] Westacott CI, Sharif M1 Cytokines in ostoarthritis: mediators ormarkers of joint destruction[J]. Semin Arthritis Rheum,1996, 25( 4): 254-272.
[9] Silaccip, Dayer JM, Desgeorges A, et al. IL-6 and its soluble receptor induce TIMP-1 expression in synoviocytes and chondrocytes and block IL-1-induced collagenolgtic activity[J]. J Biol Chem, 1998, 273( 22): 13625- 13629.
[10] 杨惠琴,陈礼容. 青藤碱注射液对兔膝骨性关节炎关节液及血清IL-6的水平影响[J].中医药导报,2007,13(10):62-63.
[11] 孟祥奇, 惠礽华, 姜宏,等. 化痰祛湿剂对兔膝骨性关节炎细胞因子IL-1、IL-6、TNFA的影响 [J]. 中国骨伤,2007,20(8):575-576.
[12] Yang Y, Gao SG, Zhang FJ, et al.Effeccs of osteopontin on the expression of IL-6 and IL-8 infummatory factors in humcon knee osteoarthritis chondrocytes[J].Eur Rev Med Pharmacol Sci, 2014,18(23):3580-3586.
[13] 陈元良,张寿,钟海波. 骨碎补总黄酮对骨性关节炎血清IL-1、IL-8及TNF-a表达的影响 [J]. 陕西中医,2013,34(9):1251-1253.
[14] 金晓东,张鸣. 红花注射液对兔膝骨关节炎软骨组织学及关节滑液PGE2、IL-8的影响 [J].中国中医骨伤科杂志,2009,17(3):18-19.
[15] 陈文超,周然,王永辉. 骨灵膏及其拆方制剂对OA模型大鼠NO、IL-10及COL-II的作用[J].光明中医,2014,29(8),1622-1625.
[16] Reboul P, Pelletier JP, Tardif G, et al. The new collagenase, collagenase-3 is expressed and synthesized by human chondrocyte but not by synoriocytes; a role in osteoarthritis[J]. J Clin Invest, 1996, 97(9): 2011- 2019.
[17] 方策,宋德为,刘元禄. 健骨活血丸对骨性关节炎模型兔关节液和血清中TNF-α表达的影响 [J]. 中国中医骨伤科杂志,2013,21(5):12-14.
[18] 肖晓金,包侠萍,陈文列,等. 透骨消痛胶囊对兔膝骨关节炎模型血清与关节液炎症因子的影响[J]. 风湿病与关节炎,2013,11(2):35-38.
[19] 朗继孝,陈德喜,王元善,等. 壮骨颗粒对兔膝骨性关节白介素-1和肿瘤坏死因子的影响 [J].山东中医杂志,2009,28(7):491-492.
[20] Livne E, LauferD, B lum en feld I. Osteoarthritis in the tem poro-m and ibular joint( TM J)of agedm ice and the in vitro effect of TGF-b eta 1 on cell proliferation,matrix synthesis, and alkaline phosphatase activity[J].Microsc Res Tech, 1997, 37( 4): 314-323.
[21] Jahag JS, Lee JW, Han CD, et al. Transforming growth factor-betal responsiveness of human articular chondrocytesin vitro: normal versus osteoarthritis[J]. Yonsei Med J, 1997,(38): 40-51.
[22] 宁显明,樊粤光,徐传毅,等. 补肾中药对膝骨关节炎软骨TGF-β1表达的影响 [J].中国中医骨伤科杂志,2004,12(1):36-38.
[23] 牛维,孙志涛,汪睦勋,等. 单味中药鹿茸调控骨关节炎软骨组织TGF-β1表达的研究[J].时珍国医国药,2014,25(3):528-531.
[24] 王孟琳,熊晓荣,王婧锦. 杜灵注射液对兔膝骨关节炎TGF- β1水平的影响作用[J].中国中医骨伤科杂志,2009,17(3):18-19.
[25] 欧阳冰,林绵辉,左文建,等. 结缔组织生长因子对体外培养的兔关节软骨细胞增殖和表型的影响[J]. 中国组织工程研究与临床康复,2009,20(13):3816-3820.
[28] Kawata K,Kubota S,Eguchi T,et a1. Role of low-density lipoprotein receptor related protein 1( lrp1)in ccn2 /connective tissue growth factor( ctgf)protein transport in hondrocytes[J]. Cell Sci,2012, 125( 12): 2965-2972.
[27] 孙剑,陈朝蔚,何永淮,等. 阳和汤对兔骨关节炎软骨细胞中结缔组织生长因子表达的影响[J].中国中医骨科杂志,2009,17(3):4-6.

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备注/Memo

备注/Memo:
作者简介: 白雯(1988- ),2013级在读硕士研究生。研究方向:中医风湿病。E-mail:619715626@qq.com 通讯作者: 阎小萍(1945- ),女,本科,主任医师,硕士研究生导师。研究方向:中医风湿病。E-mail: yanxiaoping1688@126.com
更新日期/Last Update: 1900-01-01