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人参藜芦反药组合宜忌条件的实验研究回顾与评析()

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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:: 第8卷
期数:: 2015年09期

页码:: 1064-1069

栏目:: 反药组合研究专题

出版日期:: 2015-09-06

文章信息/Info

Title:: Review on the experimental studies of suitable and contraindicant conditions of Chinese medicine antagonism compatibility ginseng and veratrum nigrum

作者:: 郭岩松; 许皖; 钟赣生; 张建美; 柳海艳; 欧丽娜; 刘佳; 赵桐; 王思睿; 100029北京中医药大学基础医学院

Author(s):: GUO Yansong; XU Wan; ZHONG Gansheng; et al.; School of Basic Medical Sciences, Beijing University of Chinese Medicine， Beijing, 100029, China

关键词:: 十八反; 人参; 藜芦; 反药组合; 宜忌条件

Keywords:: Eighteen antoganisms; Ginseng; Veratrum nigrum; Antagonism compatibility; Suitable and contraindicant conditions.

分类号:: R285.5

DOI:: 10.3969/jissn.1674-1749.2015.09.008

文献标志码:: A

摘要:: 利用中国知网、万方、维普、PubMed等数据库，系统检索1949~2014年关于中药“十八反”中人参藜芦反药组合同用的文献，从检索到的文章中剔除综述及临床研究文章，仅选取实验研究类的文章，总结归纳人参藜芦反药组合的适宜条件和禁忌条件。结合现有的实验成果，未能归纳出人参藜芦反药组合的适宜的条件，初步认为人参藜芦反药组合的禁忌条件为：人参藜芦合用，人参相当于临床最大剂量的2～10倍，藜芦相当于临床最大剂量的10～30倍；藜芦为临床最高剂量的一半，而人参为临床剂量的4～8倍；人参与藜芦配伍比例小于100∶1；红参配伍黑藜芦，生晒参配伍黑藜芦。人参藜芦入药方式、煎煮时间和复方应用因为相关研究较少或不够全面，未能归纳出禁忌条件。人参藜芦反药组合是否是绝对的配伍禁忌，不能一概而论，宜忌条件也不是固定不变的，单一条件下较难确定某一个条件是宜的条件还是忌的条件，随着多学科、多领域研究的不断深入和发展，宜忌条件也会更加丰富和充实。

Abstract:: This article summarized the suitable conditions and contraindicant conditions of antagonism compatibility ginseng and veratrum nigrum from the selected experimental research articles by searching “ginseng and veratrum nigrum compatibility of Chinese medicine Eighteen antagonism” from Wan Fang, CNKI, and VIP database since 1949. There is not enough data to summarize suitable conditions. While the contraindicant conditions are as below: the dose of ginseng is equivalent to the maximum clinical dose of 2~10 times, and the dose of veratrum nigrum is equivalent to clinical maximum dose of 10~30 times; the dose of ginseng is equivalent to the maximum clinical dose of 4~8 times, and the dose of veratrum nigrum is equivalent to half clinical maximum; the ratio of ginseng with veratrum nigrum is less than 100∶1；red ginseng with black veratrum; ginseng with black veratrum. There are contradictory to each other due to the experimental results. Whether the two herbs are absolute incompatibility or not can not be generalized and improper and proper conditions are relative, under a single condition is difficult to identify a particular condition or conditions suitable or not. With the deepening and developing studies, proper and improper conditions will be more enriched and abundent.

参考文献/References:

［1］朱大岭,韩维娜,张荣.细胞色素P450酶系在药物代谢中的作用[J].医药导报2004,23(7):440442.
［2]叶璇.基于药物代谢酶的藜芦与人参配伍禁忌研究[D].北京:军事医学科学院放射与辐射研究所，2008.
［3]王允辰,叶璇,王宇光,等.人参与藜芦合用对CYP1A酶活性的影响[J].解放军药学报，2010，26(2):104106.
［4]王宇光,高月,马增春，等.人参与藜芦合用对大鼠肝P450酶活性及mRNA表达的调控作用[C]//第十一届中国科协年会论文集,2009:308312.
［5]王宇光.基于药物代谢酶的中药相互作用研究[D].北京:军事医学科学院放射与辐射医学研究所.2006.
［6]安金娜, 徐颖, 代国靖,等. 藜芦配伍人参对未成熟小鼠雌激素样作用的影响[J]. 中国实验方剂学杂志, 2015, 21 (7): 118122
［7］关天增，潘先琼，常洪志,等.诸参辛芍叛藜芦之实验研究[J].河南中医，1993，13(5):204205.
［8]杨亮.藜芦人参配伍体内外成分变化与毒性的关联性研究[D].合肥:安徽医科大学，2013.
［9]孟浩，王宇光，肖成荣,等藜芦与人参配伍连续8周给药对大鼠心脏毒性的影响[J]. 中华中医药杂志，2013，29(3):840843.
［10]孙爱华，王于光，孟浩,等.藜芦人参配伍对大鼠肝功能及肝组织蛋白质表达的影响 [J]. 中国药理学与毒理学杂志，2013，27(6)：982986.
［11]孟莉，向绍杰，乔敏,等.均匀设计法考察藜芦对人参的耐缺氧及抗疲劳作用的影响[J].实用中医内科杂志，2010，24(2):2021.
［12]林雅, 尚尔鑫, 徐颖, 等. 基于生理病理条件考察藜芦对人参抗疲劳作用的影响[J]. 中国实验方剂学杂志, 2014, 20 (3): 9397.
［13]Lin Y, Xu Y, Shang EX,et al.Evaluating the influence of Veratrum Nigrum to Panax Ginseng based on uniform design[J]. Medicinal Plant, 2014, 5(5): 38.
［14]林雅, 徐颖, 尚尔鑫,等. 基于均匀设计法评价藜芦对人参扶正功效的影响[J]. 中国实验方剂学杂志, 2013, 19 (23): 160165.
［15]杨亮，王宇光，梁德乾,等.基于UPLC/QTOFMS不同比例人参配伍藜芦增毒的物质基础及动物毒性关联性研究[J].质谱学报,2012，33(5):257264.
［16]章斌.基于化学物质基础和代谢组学方法的中药藜芦毒性及藜芦与人参配伍禁忌机制研究[D].上海:第二军医大学，2012.
［17]梁爱葵,于艳,杨洪武,等.藜芦与人参三七西洋参配伍后藜芦定的含量变化研究 [J] .辽宁中医药杂志,2012，39(5):908909.
［18]盛伟,张语迟,王淑敏,等. 人参与藜芦配伍后人参皂苷类成分煎出量变化研究[J].中国药房, 2010，21(15):14171418.
［19]陆亚丽. 黎芦人参合用对HepG2细胞的增毒效应及肝药酶定量方法的建立[D].长沙:中南大学，2013.
［20]陆亚丽,孙爱华,高月,等.藜芦与人参合用对HepG2 细胞的增毒效应及其机制探讨[J]. 军事医学,2014，38(4):8589.
［21]张旭,宋凤瑞,王隶书,等.人参与藜芦配伍化学成分变化的HPLCESIMS 与ESIMS 研究（英文）[J].化学学报,2007，65(9):829833.
［22]杨亮,王宇光,梁德乾,等.藜芦与人参配比毒性与生物碱类成分变化的相关性研究[J].中草药,2012，43(8):15741578.
［23]王超.基于液质联用技术的乌头、藜芦配伍禁忌的化学研究[D].衡阳:南华大学,2011.
［24]王宇光,王超,梁乾德,等.十八反中藜芦与人参配伍化学成分变化的UPLC/QTOF MS 研究.（英文）[J].中国科学，2011，41(10):925932.
［25]高晓山.病理生理条件下十八反实验研究的综合报告[J].中医杂志,1991，32(1):3638.
［26]李娜,孙佳明,律广富,等.通顶散及其拆方急性毒性实验研究[J].吉林中医药,2012，32(8):825826.
［27]孙佳明,李娜,张艳平,等.HPLCMS 法对通顶散中人参藜芦相反相用物质基础研究[J]. 长春中医药大学学报,2012，28(5):909910.

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