|本期目录/Table of Contents|

[1]陈鹏辉,杨冰,季然,等.振腹对2型糖尿病大鼠血清游离脂肪酸和甘油三酯的影响[J].环球中医药,2015,8(09):1070-1073.[doi:10.3969/j.issn.1674-1749.2015.09.009]
　CHEN Peng hui,YANG Bing,JI Ran,et al.Influences of the vibrating abdomen on serum free fatty acids and triglyceride in rats with type 2 diabetes mellitus[J].,2015,8(09):1070-1073.[doi:10.3969/j.issn.1674-1749.2015.09.009]
点击复制

振腹对2型糖尿病大鼠血清游离脂肪酸和甘油三酯的影响()
     
分享到：

《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年09期
页码:
1070-1073
栏目:
论著
出版日期:
2015-09-06

文章信息/Info

Title:
Influences of the vibrating abdomen on serum free fatty acids and triglyceride in rats with type 2 diabetes mellitus
作者:
陈鹏辉; 杨冰; 季然; 谢畅; 张月; 林彩霞; 陈幼楠
100029北京中医药大学针灸推拿学院
Author(s):
CHEN Penghui;  YANG Bing;  JI Ran;  et al.
School of AcupunctureMoxibustion and Tuina,Beijing University of Chinese Medicine, Beijing 100029, China
关键词:
振腹; 2型糖尿病; 游离脂肪酸; 甘油三酯; 肾上腺
Keywords:
Vibrating abdomen; Type 2 diabetes mellitus; Free fatty acid; Triglyceride; Adrenal
分类号:
R244.1
DOI:
10.3969/j.issn.1674-1749.2015.09.009
文献标志码:
A
摘要:
目的研究振腹对2型糖尿病大鼠血清游离脂肪酸及甘油三酯的影响。方法用高糖高脂联合小剂量链脲佐菌素建立2型糖尿病大鼠模型，最终模型组11只、低频治疗组9只、高频治疗组10只，设立12只正常大鼠为对照组，予振腹治疗6周，于治疗前后监测大鼠空腹血糖、游离脂肪酸、甘油三酯的水平。多组间差异比较采用单因素方差分析。结果治疗前，与对照组对比，其余各组大鼠空腹血糖、游离脂肪酸、甘油三酯的水平均升高(P＜005)。治疗后，与模型组对比，低频治疗组和高频治疗组大鼠空腹血糖、游离脂肪酸、甘油三酯的水平均降低(P＜005)；低频治疗组和高频治疗组相比较，大鼠空腹血糖、游离脂肪酸、甘油三酯的水平无明显差异（P＞005）。结论振腹能降低2型糖尿病大鼠空腹血糖、游离脂肪酸、甘油三酯的水平，其机制可能为：（1）振腹通过调节肾上腺的分泌功能影响脂代谢；（2）增强腹部肌肉和胃肠道平滑肌运动，增加了组织对脂肪的氧化作用；（3）减少腹部及内脏脂肪异位堆积，提高腹部及内脏组织细胞胰岛素受体的敏感性。
Abstract:
ObjectiveTo study the influences of the vibrating abdomen on serum free fatty acids and triglyceride in rats with type 2 diabetes mellitus. MethodsThe rat models were established by using high sugar fatty feed combined with injection of low dose of streptozotocin, finally the rats were divided into model group (n=11), low frequency treatment group (n=9) and the high frequency treatment group (n=10), and all the treatment were lasted for 6 weeks. Another 12 normal rats were chosen as the control group. Fasting bloodglucose (FBG), free futty acid(FFA) and triglyceride(TG) were tested in pretherapy and posttreatment, and the results were analyzed by using oneway analysis of variance. ResultsCompared with the control group, the levels of FBG, FFA and TG in the rest another groups were increased significantly (P＜ 005). Compared with the model group, the levels of FBG, FFA and TG of rats in low frequency and high frequency treatment groups were decreased significantly (P＜005). The differences in the levels of FBG, FFA and TG were not significant between low frequency treatment group and high frequency treatment group (P＞005). ConclusionsVibrating abdomen could decrease the levels of FBG, FFA and TG of rats with type 2 diabetes mellitus, and the mechanism might be related with the following aspects: (1):Vibrating abdomen could influence the lipid metabolism by adjusting the secretion function of adrenal gland. (2) Vibrating abdomen could increase the lipid oxidation by strengthening the movement of abdominal muscles and gastrointestinal smooth muscles. (3) Vibrating abdomen could increase the sensitivity of insulin receptor in cells of abdomen and visceral by reducing the ectopic fat accumulation in abdomen and visceral.

参考文献/References:

［1］Leahy JL.Pathogenesis of type 2 diabetes mellitus［J］.Arch Med Res，2005，36(3):197209.
［2］付国兵，戴晓晖，国生.振腹疗法的手法操作和作用原理［J］.按摩与康复医学，2010，1(1):57.
［3］Ye Ding，Zhaofeng Zhang，Xiaoqian Dai, et al.Grape seed proanthocyanidins ameliorate pancreatic betacell dysfunction and death in lowdose streptozotocin and highcarbohydrate/highfat dietinduced diabetic rats partially by regulating endoplasmic reticulum stress［J］.Nutrition&Metabolism，2013，10(51):112.
［4］姜淼.黄连人参对药改善2型糖尿病胰岛素抵抗机制研究［D］.北京:北京中医药大学，2006:135148.
［5］司晓晨，尚文斌，卞慧敏，等.链脲佐菌素加高脂膳食诱导2型糖尿病大鼠模型［J］.安徽中医临床杂志，2003，15 (5):383385.
［6］周迎生，高妍，李斌，等.高脂喂养联合链脲佐菌素注射的糖尿病大鼠模型特征［J］.中国实验动物学报，2005，13(3):154158.
［7］夏瑢.中医三焦气化理论的应用研究对糖尿病病变机制的再探索［J］.中华中医药学刊，2008，26(3):532534.
［8］王康，戴晓晖，付国兵.振腹疗法的传承创新及其学术特色［J］.环球中医药，2013，6(6):444445.
［9］中华医学会内分泌学分会.中国2型糖尿病合并血脂异常防治专家共识(2011年)［J］.中华内分泌代谢杂志，2012，28(9):700703.
［10］杨文英.从脂毒性到糖尿病再到血脂异常［J］.国外医学内分泌分册，2004，24(4):287288.
［11］龚艳琳，陆付耳，董慧.胰岛素抵抗与脂肪异位沉积［J］.中西医结合研究，2010，2(3):144147.
［12］刘长锁，申竹芳.游离脂肪酸与胰岛素抵抗［J］.中国药理学通报，2005，21(2):145149.
［13］崔丽娟，都健，王娟.胰岛素抵抗大鼠内脏脂肪量与脂代谢紊乱的相关性研究［J］.中国现代医学杂志，2008，18(5):12301236.
［14］JY Fu，J L Masferrer，K Seibert，et al.The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes［J］.J Biol Chem，1990，265(28):1673716740.
［15］臧福科.振腹疗法［C］//北京中医药大学五十周年校庆论文集，北京,2006:585.
［16］潘长玉，金文胜.2型糖尿病流行病学［J］.中华内分泌代谢杂志，2005，21(5):增录5S15.(收稿日期： 20141129)

相似文献/References:

[1]秦灵灵 王磊 李娟娥 刘铜华.仙鹤草对2型糖尿病大鼠胰岛素抵抗及炎性因子 的干预作用[J].环球中医药,2013,6(05):333.
　QIN Ling ling,WANG Lei,LI Juan e,et al.Effects of Herba Agrimoniae on insulin resisitance and inflammatory factors in T2DM rats[J].,2013,6(09):333.
[2]刘孝琴 王云枫 李雅楠.参芪地黄汤加味配合门冬胰岛素对早期2型糖尿病肾病 负氮平衡的影响[J].环球中医药,2013,6(05):366.
[3]武志黔 郝改梅 薛晓兴 何洁等.葛根芩连汤对2型糖尿病模型大鼠作用 的研究[J].环球中医药,2014,7(03):161.
　WU Zhi qian,HAO Gai mei,XUE Xiao xing,et al.Research on the effect of Gegenqinlian Decoction on type 2 diabetic model[J].,2014,7(09):161.
[4]孙冉冉,郑燕飞,李玲孺,等.从中医体质角度探讨2型糖尿病的防治[J].环球中医药,2014,7(05):375.
[5]乔海平.辨证论治结合西药治疗2型糖尿病150例[J].环球中医药,2012,5(10):778.
[6]乔海平.浅谈2型糖尿病的临床疗效评价标准[J].环球中医药,2012,5(11):825.
[7]张有涛,秦泗关,吴晓青,等.自拟黄苓泽泻汤治疗2型糖尿病合并高尿酸血症30例[J].环球中医药,2012,5(11):854.
[8]乔海平.2型糖尿病及其并发症中医临床疗效评价研究进展[J].环球中医药,2012,5(12):956.
　QIAO Hai-ping..Progress on the clinical curative effect evaluation of traditional Chinese medicine treatment on type 2 diabetes and its complications[J].,2012,5(09):956.
[9]谢莎莎.张学智治疗2型糖尿病的经验总结[J].环球中医药,2015,8(09):1105.[doi:10.3969/j.issn.1674-1749.2015.09.020]
[10]刘崇喜.金芪降糖经验汤剂联合二甲双胍对气虚内热证2型糖尿病患者糖脂代谢及血管内皮功能的影响[J].环球中医药,2016,9(06):737.[doi:10.3969/j.issn.1674-1749.2016.06.029]

备注/Memo

备注/Memo:
-
更新日期/Last Update: 1900-01-01