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[1]汤明杰,叶永山,张旗,等.牡丹皮对内毒素性急性肺损伤大鼠的保护作用[J].环球中医药,2015,8(10):1167-1170.[doi:10.3969/j.issn.1674.1749.2015.10.004]
　TANG Ming jie,YE Yong shan,ZHANG Qi,et al.Protective effects of Moutan cortex on lipopolysaccharideinduced acute lung injury in rats[J].,2015,8(10):1167-1170.[doi:10.3969/j.issn.1674.1749.2015.10.004]
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牡丹皮对内毒素性急性肺损伤大鼠的保护作用()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年10期
页码:
1167-1170
栏目:
论著
出版日期:
2015-10-06

文章信息/Info

Title:
Protective effects of Moutan cortex on lipopolysaccharideinduced acute lung injury in rats
作者:
汤明杰; 叶永山; 张旗; 苏浬; 赵跃东; 曹春琪; 雷海民; 李强
100102 北京中医药大学中药学院
Author(s):
TANG Mingjie; YE Yongshan; ZHANG Qi; et al.
School of Traditional Chinese Medicine，Beijing University of Chinese Medicine，Beijing 100102，China
关键词:
牡丹皮; 急性肺损伤; 内毒素
Keywords:
Moutan cortex; Acute lung injury; Lipopolysaccharide
分类号:
R2855
DOI:
10.3969/j.issn.1674.1749.2015.10.004
文献标志码:
A
摘要:
目的探讨牡丹皮对内毒素（lipopolysaccharide ,LPS）诱导的大鼠急性肺损伤（acute lung injury，ALI）的治疗作用，并探讨其可能机制。方法60只wistar大鼠随机分为生理盐水对照组、模型组、地塞米松组、治疗组及预防组，每组12只，通过向气管内滴注LPS建立大鼠ALI模型。观察造模12小时后的肺泡灌洗液中多形核白细胞（polymorphonuclear leukocytes，PMN）百分比、蛋白浓度、肿瘤坏死因子（tumor necrosis factoralpha，TNFα）及白细胞介素6（interleukin6，IL6）水平和肺组织的病理形态学变化。结果牡丹皮、地塞米松能够有效地降低PMN百分比和蛋白浓度（P＜001），下调TNFα、IL6的水平﹙P＜005或P＜001），显著减轻肺泡结构破坏、肺水肿和炎症细胞浸润等病变。结论牡丹皮能够抑制ALI时的炎症反应，减轻肺部炎症损伤，从而对肺起到保护作用。
Abstract:
ObjectiveTo investigate the effects of Moutan cortexon lipopolysaccharideinduced acute lung injury (ALI) in rats，and explore the underlying mechanism against ALI. Methods55 wistar rats were randomly divided into control group, model group,positive drug group,treatment group and prevention group,the animal model of ALI was established by intratracheal administration oflipopolysaccharide.The percentage of neutrophils﹑the concentration of protein exudation﹑cytokine(TNFα、IL6) levels in bronchoalveolar lavage fluid (BALF) and histopathological changes in lung tissue were observed 12 h after LPS administration.ResultsMoutan cortex and dexamethasone can effectively reduce the PMN percentage and protein concentration(P＜001), lower the level of TNFα﹑IL6 (P＜005 or P＜001) ,significantly improve the alveolar structure damage﹑pulmonary edema and inflammatory cells infiltration, etc. ConclusionMoutan cortex can protect lung through inhibiting the inflammation reaction of ALI and alleviating pulmonary inflammation.

参考文献/References:

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相似文献/References:

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更新日期/Last Update: 1900-01-01