|本期目录/Table of Contents|

[1]董国菊,刘剑刚,张庆翔,等.活血解毒中药组分配伍对急性心肌梗死后缺血心肌病理形态和心功能的影响[J].环球中医药,2015,8(11):1340-1345.[doi:10.3969/j.issn.1674-1749.2015.11.017]
　DONG Guo ju,LIU Jian gang,ZHANG Qing xiang,et al.The protective effects of component compatibility of Huoxue and detoxification on ischemic myocardium and cardiac function after acute myocardial infarction[J].,2015,8(11):1340-1345.[doi:10.3969/j.issn.1674-1749.2015.11.017]
点击复制

活血解毒中药组分配伍对急性心肌梗死后缺血心肌病理形态和心功能的影响()
     
分享到：

《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年11期
页码:
1340-1345
栏目:
论著
出版日期:
2015-11-06

文章信息/Info

Title:
The protective effects of component compatibility of Huoxue and detoxification on ischemic myocardium and cardiac function after acute myocardial infarction
作者:
董国菊; 刘剑刚; 张庆翔; 张蕾; 张大武
100091北京，中国中医科学院西苑医院心血管病中心；中国中医科学院心血管病研究所
Author(s):
DONG Guoju;  LIU Jiangang;  ZHANG Qingxiang;  et al.
Xiyuan Hospital, China Academy of Chinese Medical Sciences; Institute of Cardiovascular Disease of China Academy of Chinese Medical Sciences, Beijing 100091, China
关键词:
急性心肌梗死; 心室重构; 赤芍总苷; 黄连生物碱; 活血解毒; 组分配伍
Keywords:
Acute Myocardial Infarction; Ventricular Remodeling; Total paeony glycoside; Alkaloids of rhizome; Promoting Blood Circulation and Detoxification; Component Compatibility
分类号:
R285；R542.22
DOI:
10.3969/j.issn.1674-1749.2015.11.017
文献标志码:
A
摘要:
目的探讨活血解毒中药（赤芍总苷、黄连生物碱）组分配伍对实验性急性心肌梗死大鼠早期心室重构的缺血心肌病理形态及心功能的影响。方法实验用健康Wistar大鼠，雄性，体质量180～200 g，水合氯醛腹腔麻醉，结扎冠状动脉左前降支造成急性心肌梗死模型，手术成活大鼠随机分为模型组、中药活血组（赤芍总苷）、中药解毒组（黄连生物碱）、活血解毒组（赤芍总苷+黄连生物碱）、辛伐他汀组共5组，每组10只，术后连续给药14天。另设假手术组（结扎线穿过冠状动脉左前降支，不接扎）10只，和模型组给予等量蒸馏水。末次给药后空腹16小时，然后麻醉做心脏超声多普勒检测，结束后腹主动脉取血，放射免疫方法检测血清中的白细胞介素1β，肿瘤坏死因子α和高敏C反应蛋白的炎症水平，心肌组织分别取材处理，光镜和电镜观察心肌组织的结构变化。结果和模型组比较，赤芍总苷组、黄连生物碱组和活血解毒组分配伍对大鼠血清白细胞介素1β，肿瘤坏死因子α和高敏C反应蛋白含量均有显著抑制作用（P<0.05，P<0.01），赤芍总苷组和活血解毒组治疗的心肌细胞形态较为整齐，炎症细胞浸润明显减少，心肌线粒体结构较为完整；和模型组比较，活血解毒组大鼠的左心室面积显著缩小（P<0.05），心脏超声显示的左室舒张末内径和收缩末内径减少（P<0.05），左室射血分数显著提高（P<0.05）。结论赤芍总苷和黄连生物碱配伍具有一定的综合优势。活血解毒组配伍能够干预急性心肌梗死后早期心室重构，抑制血清炎症水平，保护缺血心肌细胞，促进心脏功能的恢复。
Abstract:
ObjectiveTo discuss the protective effects of component compatibility of total paeony glycoside (TPG) and alkaloids of rhizome (AR) on ischemic myocardium and cardiac function of ventricular remodeling (VR) rats after acute myocardial infarction (AMI). MethodsThe Wistar rats were randomLy divided into 6 groups, including shamoperated group，model group, simvastatin group, TPG group, AR group, total TPG and AR group. Continuously administrated drugs for 14 days. The shamoperated and model group were given the same dosage distilled water. 16 hours after the last administration, anesthetized and detected the cardiac doppler ultrasound, the level of interleukin 1 beta (IL1β), tumor necrosis factor alpha (TNFα) and hypersensitive Creactive protein (hsCRP).The pathological structural changes of myocardial tissue were observed by light microscope and electron microscope. ResultsCompared with the model group, the level of IL1β, TNFαand hsCRP significantly decreased than those in TPG, AR and both TPG and AR group（P<0.05，P<0.01）; The morphology of cardiac muscle cells and mitochondrion is more regular and less inflammatory cells infiltration in TPG and both TPG and AR group; compared with the model group, the left ventricular area obviously reduced in the TPG，AR， simvastain and both TPG and AR group（P<0.05）; 1eft ventricular endsystole dimension(LVEDs) and left ventricular enddiastole dimension (LVEDd） significantly decreased and left ventricular ejection fraction (LVEF) significantly increased in the TPG，AR， simvastain and both TPG and AR group（P<005）. Among them, the both TPG and AR group show greater advantages. ConclusionsThe component compatibility of TPG and AR could intervene the early VR after AMI, inhibit the inflammation factors, protect ischemic myocardium and promote the recovery of cardiac function.

参考文献/References:

［1]Christia P,Frangogiannis NG.Targeting inflammatory pathways in myocardial infarction[J]. Eur J Clin Invest,2013,43(9):986995.
[2]]Zhou SX,Zhou Y,Lei J,et al.Effects of oxidative stress on ventricular remodeling after myocardial infarction in rats[J]. Nan Fang Yi Ke Da Xue Xue Bao,2008,28(11):20302040.
[3]]Ishida K,Geshi T,Nakano A,et al.Beneficial effects of statin treatment on coronary microvascular dysfunction and left ventricular remodeling in patients with acute myocardial infarction[J].Int J Cardiol,2012,155(3):442447.
[4]]Sawhney JP1.Angiotensine converting enzyme inhibitors In acute myocardial infarctiona review[J]. Indian Heart J,2011,63(1):7178.
[5]]Khan HA，Alhomida AS，Sobki SH．Lipid profile of patients with acute myocardial infarction and its correlation with systemic inflammation[J]．Biomark Insights，2013，(8)：17．
[6]]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.急性ST段抬高型心肌梗死诊断和治疗指南[J].中华心血管病杂志，2010,38（8）：675690.
[7]]董国菊.中医药干预急性心肌梗死后心室重构的机理研究进展[J].环球中医药,2013,6(10):783787.
[8]]徐伟，刘剑刚，王承龙，等.益气养阴与解毒活血中药对心肌梗死后大鼠早期心室重构心肌NFKB和PPAR—Y mRNA表达的影响[J].北京中医药大学学报，2010，33（5）:333338.
[9]]Eftychia Demerouti,Evangelos Leontiadis,George Karatasakis,et al.Left ventricular geometry and systolic function improvement after percutaneous closure of aortic prosthetic paravalvular leak[J]. The Journal of heart valve disease, 2013,22(6):862866.
[10]艾文婷，姜宝周，梁磊.B型钠尿肽、高敏C 反应蛋白与急性心肌梗死患者心功能关系的临床研究［J］.中国医药导报，2012，9（25）：4243.
[11]李旭，王迪，罗世红.急性心肌梗死后心脏生物标志物的变化及其与左心功能和左心室重构的关系[J].中国实用医刊，2014,3（41）：5153.
[12]吴伟，刘勇，李荣，等.急性心肌梗死患者证侯特点的回顾性研究[J].广州中医药大学学报，2012,29（5）：502504.
[13]范景辉，赵玉梅，李志平.小檗碱的药理作用研究[J].中国药物经济学，2014,4(6)：220221.
[14]王琳琳,丁安伟.赤芍总苷对大鼠血瘀证模型的影响[J].南京中医药大学学报，2011,27（6）:552555.
[15]杨金果，李珩，李运伦.中药有效组分配伍的研究进展[J].上海中医药杂志,2012,46(3):8992.

相似文献/References:

[1]董国菊.中医药干预急性心肌梗死后心室重构的机理研究进展[J].环球中医药,2013,6(10):783.
　DONG Guo ju..Mechanism research progress on intervention of TCM on ventricular remodeling after acute myocardial infarction[J].,2013,6(11):783.

备注/Memo

备注/Memo:
-
更新日期/Last Update: 1900-01-01