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[1]何佩珊,胡凯文,李泉旺,等.中药干预对老年晚期非小细胞肺癌氩氦刀冷冻术前后证型的影响[J].环球中医药,2015,8(11):1354-1358.[doi:10.3969/j.issn.1674-1749.2015.11.020]
　HE Pei shan,HU Kai wen,LI Quan wang,et al.Effects of Chinese medicinal interventions on patterns of syndrome to the elderly patients with nonsmall cell lung cancer before and after argonhelium cryoablation[J].,2015,8(11):1354-1358.[doi:10.3969/j.issn.1674-1749.2015.11.020]
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中药干预对老年晚期非小细胞肺癌氩氦刀冷冻术前后证型的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年11期
页码:
1354-1358
栏目:
论著
出版日期:
2015-11-06

文章信息/Info

Title:
Effects of Chinese medicinal interventions on patterns of syndrome to the elderly patients with nonsmall cell lung cancer before and after argonhelium cryoablation
作者:
何佩珊; 胡凯文; 李泉旺; 姜敏; 刘传波; 冯兴中
100038北京，首都医科大学附属北京世纪坛医院中医科（何佩珊、冯兴中）;北京中医药大学东方医院肿瘤科（李泉旺、姜敏、刘传波、胡凯文）
Author(s):
HE Peishan;  HU Kaiwen;  LI Quanwang;  et al.
Traditional Chinese Medicine Department of Beijing Shijitan Hospital, Capital Medical University， Beijing 100038, China
关键词:
老年晚期非小细胞肺癌; 氩氦刀冷冻术; 证型
Keywords:
Elderly Patients with Lung Cancer;  ArgonHelium knife cryotherapy; Syndromes
分类号:
R828.3
DOI:
10.3969/j.issn.1674-1749.2015.11.020
文献标志码:
A
摘要:
目的研究老年晚期非小细胞肺癌（nonsmall cell lung cancer,NSCLC）患者氩氦刀冷冻治疗前后的证候类型变化规律，及基于辨证论治中药干预对老年晚期非小细胞肺癌患者氩氦刀冷冻治疗后证型的影响。方法收集自2011年9月至2014年9月期间老年晚期NSCLC并接受氩氦刀冷冻治疗患者共130例，分为中西医结合组65例（予辨证中药治疗+最佳对症治疗）和西医治疗组65例（仅予最佳对症支持），分别于术前1天、术后1周、术后1月、术后3月进行辨证，比较两组氩氦刀冷冻术前后证型变化情况。结果（1）老年晚期NSCLC患者氩氦刀冷冻术前后均以气虚、痰湿、阴虚、血瘀为主要证型；（2）气虚证：两组比较，术后1月和术后3月中西医结合组气虚证例数比西医治疗组少（P＜005）；西医治疗组气虚证例数于术后1周和术后3月比术前增多（P＜0.05）；（3）痰湿证：两组比较，术后1月、术后3月中西医结合组痰湿证例数比西医治疗组少（P＜0.05）；西医治疗组术后1月、术后3月痰湿证例数比术前增多（P＜0.05）；（4）血瘀证：西医治疗组术后1月、术后3月血瘀证例数比术前增多（P＜0.05）。结论气虚、痰湿、阴虚、血瘀是老年晚期NSCLC患者氩氦刀冷冻治疗前后最主要的证型。基于辨证论治使用中药能有效改善氩氦刀冷冻术后气虚证、痰湿证、血瘀证，明显优于单纯西医治疗患者，中医当以益气养阴、祛痰化瘀为主要治疗原则。
Abstract:
ObjectiveTo investigate the changing rules of TCM syndrome patterns, the possible factors contributing to changes of syndrome patterns, and the effects of the Chinese medicinal interventions based on syndrome differentiation before and after Argonhelium cryoablation on elderly patients with nonsmall cell lung cancer (NSCLC). Methods130 NSCLC Patients were divided into two groups. 65 patients from Combination Group (Group I) were given the treatments of TCM combined with best supportive care (BSC) after argonhelium cryoablation. The rest 65 patients of Western Medicine Multimodality (group II) were given the treatments of BSC alone. TCM syndrome types were observed and analyzed on the 1st day before operation, 1 week, 1 month and 3 months after the surgery respectively.ResultsThe patterns of syndrome could be mainly classified into 4 patterns: qi deficiency, yin deficiency, phlegmdamp and blood stasis.（1）Qi deficiency syndrome：the frequency of qi deficiency in group I was less than those in group II 1 month and 3 months after the surgery（P＜0.05）. The frequency of qi deficiency in group II was increased 1 week and 3 months after the surgery with statistical difference (P＜0.05).（2）Yin deficiency syndrome：there were no statistical differences of the frequency of yin deficiency between 2 groups（P＞0.05).（3）Dampnessphlegm syndrome: the frequency of dampnessphlegm in group I was less than group II 1 month and 3 months after the surgery（P＜0.05）. The frequency of dampnessphlegm in group II was increased 1 month and 3 months after the surgery, with statistical difference (P＜0.05). （4）Blood stasis: the frequency of blood stasis in group II was increased 1 month and 3 months after the surgery with statistical difference (P＜0.05).ConclusionTCM treatments based on syndrome differentiation can significantly improve effectiveness of treatments, especially for qi deficiency, phlegmdamp and blood stasis. Moreover, the following principles can be used to guide clinical treatments: reinforcing qi, nourishing yin, eliminating phlegm and resolving stasis.

参考文献/References:

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[3]]中国抗癌协会肺癌专业委员会.2010中国肺癌临床指南[M].北京：人民卫生出版社，2010:31.
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[6]]何佩珊,刘传波,张可睿,等.应用“护场”理论治疗乳腺癌溃疡1例[J].中国中西医结合外科杂志,2013,(6):712713.

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更新日期/Last Update: 1900-01-01