[1]000,北京中医药大学中药学院\[张晴（硕士研究生）、杜守颖、陆洋、白洁、李鹏跃、滕会会（硕士研究生）、杜秋（硕士研究生）\].不同血塞通胶囊的人参皂及三七皂苷溶出度对比研究[J].环球中医药,2015,8(11):1362-1366.[doi:10.3969/j.issn.1674-1749.2015.11.022]
ZHANG Qing,DU Shou ying,LU Yang,et al.Comparison of dissolution of ginsenoside and notoginsenoside form different Xuesaitong capsules〓〖WTBX〗[J].,2015,8(11):1362-1366.[doi:10.3969/j.issn.1674-1749.2015.11.022]
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不同血塞通胶囊的人参皂及三七皂苷溶出度对比研究(
)
ZHANG Qing,DU Shou ying,LU Yang,et al.Comparison of dissolution of ginsenoside and notoginsenoside form different Xuesaitong capsules〓〖WTBX〗[J].,2015,8(11):1362-1366.[doi:10.3969/j.issn.1674-1749.2015.11.022]
)《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]
- 卷:
- 第8卷
- 期数:
- 2015年11期
- 页码:
- 1362-1366
- 栏目:
- 论著
- 出版日期:
- 2015-11-06
文章信息/Info
- Title:
- Comparison of dissolution of ginsenoside and notoginsenoside form different Xuesaitong capsules〓〖WTBX〗
- 作者:
- 100102; 北京中医药大学中药学院\[张晴（硕士研究生）、杜守颖、陆洋、白洁、李鹏跃、滕会会（硕士研究生）、杜秋（硕士研究生）\]
- 100102北京中医药大学中药学院[张晴（硕士研究生）、杜守颖、陆洋、白洁、李鹏跃、滕会会（硕士研究生）、杜秋（硕士研究生）]
- Author(s):
- ZHANG Qing; DU Shouying; LU Yang; et al.
- School of Chinese Medicin, Beijing University of Chinese Medicine, Beijing 100102,China.
- 关键词:
- 〖HTSS〗血塞通胶囊; 缓释; 多成分; 质量权重系数法
- Keywords:
- Xuesaitong capsule; 〓Sustainedrelease; 〓Multicomponent; 〓Quality weight coefficient method
- 分类号:
- R286
- 文献标志码:
- A
- 摘要:
- 目的建立测定血塞通胶囊中人参皂苷Rg1、Re、Rb1、Rd及三七皂苷R1溶出度的检测方法，并比较3种不同血塞通胶囊溶出度情况，为剂型改进提供依据。 方法采用HPLC法检测5种皂苷的体外溶出度，计算并绘制累积溶出曲线，通过相似因子（f2）分别比较不同血塞通胶囊间5种皂苷溶出度的差异及每种胶囊中各皂苷间的溶出度差异，并采用质量权重系数法将血塞通胶囊中三七总皂苷组分的溶出曲线进行整合。 结果维和硬胶囊和络泰软胶囊中5种皂苷在30 分钟内累积溶出率均达到60%以上，12 小时内均达到85%以上，而理洫王软胶囊各成分成分30 分钟累积溶出率仅为3%，12 小时内达到40%，3种血塞通胶囊间溶出曲线f2均小于50，各胶囊中5种皂苷间f2均大于50。3种血塞通胶囊的溶出过程存在显著性差异，以油相为内容物基质的理洫王软胶囊相对于维和硬胶囊及络泰软胶囊显示出缓释作用， 5种皂苷间溶出行为无显著性差异，呈现出同步性，与整合结果趋势相同。 结论胶囊壳及内容物基质的不同对胶囊的溶出过程存在一定的影响，油相基质具有缓释作用，血塞通胶囊中5种皂苷的溶出具有同步性。
- Abstract:
- Objective〓〖WTBZ〗To establish the methods for determining the dissolution of ginsenoside Rg1,Re,Rb1,Rd and notoginsenoside R1 in Xuesaitong capsuls，and study the dissolution condition of the three capsules，which can provide a basis for the improvement of dosage form. 〖WTHZ〗Methods〓〖WTBZ〗HPLC and UV were used to detect the in vitro dissolution in the three capsules, respectively,cumulative dissolution curves were drawn and similar factors of the curves were compared. Furthermore, the multicomponernt drug release curves were integrated by using Weight coeffieient method.〖WTHZ〗 Results〓〖WTBZ〗The dissolution of the five saponins in Weihe hard capsule and Luotai soft capsule were all over 60% within 30 minutes，and over 85% within 12 hours.While the dissolution of the five saponins in Lixuwang soft capsule in were all over 3% within 30 minutes，and over 40% within 12 hours.The similarity factor(f2) values of the dissolution of different capsules were all less than 50 and that of the five saponins were all more than 50.The dissolution of different Xuesaitong capsules has significant differences. The Lixuwang soft capsule which had oily contents showed sustained release effect compared with the other two capsules.〖WTHZ〗Conclusion〓〖WTBZ〗Different shells and contents have a certain influence on the dissolution of Xuesaitong capsules. The oily contents shows sustained release effect . The five saponins could release from the capsule synchronously.
参考文献/References:
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