[1]许树才.大黄黄连泻心汤对慢性萎缩性胃炎胃液成分及肿瘤标记物的影响[J].环球中医药,2015,8(12):1425-1428.[doi:10.3969/j.issn.1674.1749.2015.12.001]
XU Shu-cai.Effect of Dahuang Huanglian Xiexin decoction intervention in gastric juice components and tumor markers in patients with chronic atrophic gastritis with gastric precancerous lesions[J].,2015,8(12):1425-1428.[doi:10.3969/j.issn.1674.1749.2015.12.001]
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大黄黄连泻心汤对慢性萎缩性胃炎胃液成分及肿瘤标记物的影响(
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XU Shu-cai.Effect of Dahuang Huanglian Xiexin decoction intervention in gastric juice components and tumor markers in patients with chronic atrophic gastritis with gastric precancerous lesions[J].,2015,8(12):1425-1428.[doi:10.3969/j.issn.1674.1749.2015.12.001]
)《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]
- 卷:
- 第8卷
- 期数:
- 2015年12期
- 页码:
- 1425-1428
- 栏目:
- 论著
- 出版日期:
- 2015-12-06
文章信息/Info
- Title:
- Effect of Dahuang Huanglian Xiexin decoction intervention in gastric juice components and tumor markers in patients with chronic atrophic gastritis with gastric precancerous lesions
- 作者:
- 许树才
- 430015 武汉,湖北省中西医结合医院肿瘤内科
- Author(s):
- XU Shu-cai
- Hubei Province in Integrative Medicine Hospital Medical Oncology, Wuhan 430015, China
- Keywords:
- Chronic atrophic gastritis; Precancerous lesion; Dahuang Huanglian Xiexin decoction; Gastric juice; Tumor markers
- 分类号:
- R259
- 文献标志码:
- A
- 摘要:
- 目的 探讨大黄黄连泻心汤治疗慢性萎缩性胃炎胃癌前病变的疗效及对患者胃液成分及肿瘤标记物的影响。方法 慢性萎缩性胃炎胃癌前病变患者94例,随机分成对照组和观察组各47例。对照组:接受常规西医治疗。观察组:接受常规西医治疗,同时结合中药汤剂大黄黄连泻心汤治疗。结果 观察组总有效率为85.11%高于对照组总有效率61.70%,差异具有统计学意义(P<0.05)。治疗后,观察组患者的症状积分低于对照组患者的症状积分,差异具有统计学意义(P<0.01)。治疗后,观察组患者的游离酸水平(18.6±5.2)g/L、总酸水平(42.0±10.5)g/L高于对照组患者的游离酸水平(13.7±4.4)g/L、总酸水平(30.2±8.7)g/L,差异具有统计学意义(P<0.01)。治疗后,观察组患者的乳酸(49.5±7.3)mmol/L、亚硝酸盐(71.9±13.6)mg低于对照组患者的乳酸(63.2±9.1)mmol/L、亚硝酸盐(118.1±19.8)mg,差异具有统计学意义(P<0.01)。治疗后,观察组患者胃液及血液中糖链抗原19-9(CA19-9)、糖链抗原125(CA125)、糖链抗原72-4(CA72-4)与癌胚抗原(CEA)水平均低于对照组患者胃液中CA19-9、CA125、CA72-4与CEA,差异具有统计学意义(P<0.01)。结论 大黄黄连泻心汤用于治疗慢性萎缩性胃炎胃癌前病变疗效确切,可显著缓解患者的症状,并能够有效改善胃液成分、降低机体内肿瘤标记物的含量,抑制胃癌前病变的进展。
- Abstract:
- Objective To investigate the effect of Dahuang Huanglian Xiexin decoction intervention in gastric juice components and tumor markers in patients with chronic atrophic gastritis of gastric precancerous lesions.Methods 94 cases of patients with chronic atrophic gastritis of gastric precancerous lesions were randomly divided into control group and observation group, 47 cases in each. The control group were given conventional western medicine treatment. The observation group were given conventional western medicine treatment combined with Dahuang Huanglian Xiexin decoction treatment.Results The total effective rate of observation group was 85.11% which was higher than that was 61.70% in the control group, the result had statistically significant difference(P<0.05). After treatment, symptom scores of the observation group were lower than those of control group, the results had significant difference(P<0.01). After treatment, the free acid levels(18.6±5.2)g/L, the total acid level(42±10.5)g/L in the observation group were higher than the free acid levels(13.7±4.4)g/L, the total acid level(30.2±8.7)g/L in the control group, the difference was statistically significant(P<0.01). After treatment, lactic acid(49.5±7.3)mmol/L, nitrite(71.9±3.6)mg in the observation group were lower than the lactic acid(63.2±9.1)mmol/L, nitrite(118.1±19.8)mg in the control group, the difference was statistically significant(P<0.01). After the treatment, CA19-9, CA125, CA72-4 and CEA levels in gastric juice and serum of the observation group were lower than those of control group, the difference was statistically significant(P<0.01).Conclusions Dahuang Huanglian Xiexin decoction in the treatment of chronic atrophic gastritis precancerous lesions of gastric cancer has good curative effect. The decoction can significantly alleviate the symptoms of patients and can effectively improve the gastric juice composition, and it also can reduce tumor marker content inside the body and inhibit the progression of precancerous lesions of gastric cancer.
参考文献/References:
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