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[1]张成,赵志付,李健.基于脑电超慢涨落信号探究心身疾病肝郁气滞证脑内神经递质特征[J].环球中医药,2015,8(12):1429-1432.[doi:10.3969/j.issn.1674.1749.2015.12.002]
　ZHANG Cheng,ZHAO Zhi-fu,LI Jian..Research on the characteristics of cerebralneurotransmitters levels of ‘Stagnation of QI due to depression of the liver' syndrome of psychosomatic diseases based on super encephalofluctuograph technology[J].,2015,8(12):1429-1432.[doi:10.3969/j.issn.1674.1749.2015.12.002]
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基于脑电超慢涨落信号探究心身疾病肝郁气滞证脑内神经递质特征()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年12期
页码:
1429-1432
栏目:
论著
出版日期:
2015-12-06

文章信息/Info

Title:
Research on the characteristics of cerebralneurotransmitters levels of ‘Stagnation of QI due to depression of the liver' syndrome of psychosomatic diseases based on super encephalofluctuograph technology
作者:
张成; 赵志付; 李健
100053 北京,中国中医科学院广安门医院心身医学科
Author(s):
ZHANG Cheng;  ZHAO Zhi-fu;  LI Jian.
Guang'Anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
关键词:
肝郁气滞证;  心身疾病;  脑电超慢涨落;  神经递质;  脑电信号
Keywords:
‘Stagnation of QI due to depression of the liver' syndrome;  Psychosomatic diseases;  Super encephalofluctuograph technology;  Neurotransmitters;  Electroencephalogram(EEG)signals
分类号:
R542.2+2
DOI:
10.3969/j.issn.1674.1749.2015.12.002
文献标志码:
A
摘要:
目的 从脑内神经递质活性改变方面探究心身疾病肝郁气滞证的生物学标记。方法 本研究以“证病结合” “以方测证”为研究方法,采用脑电信号非线性分析法——脑电超慢涨落分析法为技术手段,把经柴胡疏肝散加减治疗2～8周后疗效为显效、临床痊愈的主证为肝郁气滞证的患者治疗前的脑电超慢涨落图和健康人对照组的脑电超慢涨落图加以对照分析,比较两组脑内5-羟色胺(5-hydroxytryptamine,5-HT)、多巴胺(dopamine,DA)、去甲肾上腺素(norepinephrine,NE)的激活情况。其中,肝郁气滞证患者27例,健康人对照组23例。结果 与健康人对照组比较,肝郁气滞证患者在C4脑区的5-HT激活水平下降(P<0.05),在F4、C4脑区DA激活水平下降(P<0.05),在C3、P3脑区NE激活水平升高(P<0.05)。 结论 心身疾病肝郁气滞证在脑电超慢涨落图上有脑内神经递质活性的规律性表现。初步从脑电生理学和脑内神经递质活性改变方面,揭示出心身疾病肝郁气滞证的生物学标记。
Abstract:
Objective To explore the biological marker of ‘Stagnation of QI due to depression of the liver' syndrome of psychosomatic diseases from the aspect of brain neurotransmitters levels. Methods Syndromes are the core while diseases are the complement. The accuracy of Syndrome Differentiation has been verifyed by the curative effects of fixed traditional Chinese medicine(TCM)prescription from 2 to 8 weeks. Each case was summarized by curative effects according to efficacy standards of different diseases. Only the case of recovery and special effect could be enrolled in this study. Super Encephalofluctuograph Technology(SET, nonlinear analysis of EEG)was used for measuring brain neurotransmitters levels. Each case has been measured by SET before treatment. 27 cases of the ‘Stagnation of QI due to depression of the liver' syndrome and 23 healthy volunteers of the control group were enrolled in this study. Results The syndrome of ‘Stagnation of QI due to depression of the liver' had a descending trend of 5-HT level in C4 region(P<0.05)and DA level in F4 and C4 regions was decreased(P<0.05). The syndrome of ‘Stagnation of QI due to depression of the liver' had increase NE level in C3 and P3 regions(P<0.05).Conclusions This study has preliminarily demonstrated the regularities and specificities of the change of brain neurotransmitters levels of the ‘Stagnation of QI due to depression of the liver' syndrome in SET. This study has preliminarily indicates the biological marker of ‘Stagnation of QI due to depression of the liver' syndrome of psychosomatic diseases from the aspects of brain electrophysiology and brain neurotransmitters levels.

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更新日期/Last Update: 1900-01-01