|本期目录/Table of Contents|

[1]杨瑾,莫国栋,宋凤兰,等.柴苓护肝颗粒的优化工艺[J].环球中医药,2015,8(12):1455-1459.[doi:10.3969/j.issn.1674.1749.2015.12.008]
　YANG Jin,MO Guo-dong,SONG Feng-lan,et al.Optimizationprocess of Chailing Hugan granule[J].,2015,8(12):1455-1459.[doi:10.3969/j.issn.1674.1749.2015.12.008]
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柴苓护肝颗粒的优化工艺()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第8卷
期数:
2015年12期
页码:
1455-1459
栏目:
论著
出版日期:
2015-12-06

文章信息/Info

Title:
Optimizationprocess of Chailing Hugan granule
作者:
杨瑾; 莫国栋; 宋凤兰; 李嘉良; 曾维国; 林丽
528400 广东省中山市第二人民医院药剂科(杨瑾、莫国栋、李嘉良、曾维国、林丽); 广东药学院医药化工学院(宋凤兰)
Author(s):
YANG Jin;  MO Guo-dong;  SONG Feng-lan;  et al.
Zhongshan Second People's Hospital, Zhongshan 528447, China
关键词:
柴苓护肝颗粒;  正交设计;  水提工艺;  柴胡皂苷
Keywords:
Chailing Hugan granule;  Orthogonal design;  Water-extraction technology;  Saikoside
分类号:
R284.2
DOI:
10.3969/j.issn.1674.1749.2015.12.008
文献标志码:
A
摘要:
目的 探讨柴苓护肝颗粒的工艺优化研究。方法 通过正交实验以干膏得率和总皂苷含量为指标,对水提工艺和醇沉工艺分别进行了优化,水提部分对药材浸泡时间、煎煮时间、煎煮次数、加水量进行了考察,醇沉部分对醇沉浓度、醇沉时间、浓缩液相对密度进行了优选,筛选出最佳提取工艺。结果 柴苓护肝颗粒的最佳水提工艺为加10倍量水,药材浸泡3小时,提取2次,每次提取2小时。最佳醇沉工艺为提取液浓缩至相对密度为1.16～1.20,加乙醇使含醇量为50%,静置36小时。结论 该工艺稳定可行,合理可靠。
Abstract:
Objective To discuss the optimization process of Chailing Hugan granule. Methods To optimize the water-extracting process and ethanol-extracting process respectively based on the indexes as dry extract yielding rate and total saponins contents by using orthogonal design. In water-extracting process, soaking time, decocting time, decocting frequencies and the additive quantity of water of herb decocting were observed. In ethanol-extracting process, alcohol concentration, soaking time and relative density of concentrated solution were optimized, in order to select the best extraction process. Results The optimization water-extracting process of Chailing Hugan granule was as follows: 10 times of water quantity was added, and herbs were soaked for 3 hours and extracted 2 times with 2 hours for each extraction. The optimization ethanol-extracting process of Chailing Hugan granule was as follows: adding ethanol to the ethanol content of 50%, placed statically for 36 hours and extracted the concentrated solution with relative density in the range of 1.16～1.20. Conclusion This process was stable, practical, reasonable and reliable.

参考文献/References:

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更新日期/Last Update: 1900-01-01