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[1]张润莲,岳斌,李维,等.加味升阳益胃汤组方对荷瘤小鼠化疗后骨髓抑制及免疫功能的影响[J].环球中医药,2016,9(03):291-294.[doi:10.3969/j.issn.1674-1749.2016.03.009]
　ZHANG Run lian,YUE Bin,LI Wei,et al.Effects of Jiawei Shengyang Yiwei decoction on bone marrow and immune function after chemotherapy in tumor bearing mice[J].,2016,9(03):291-294.[doi:10.3969/j.issn.1674-1749.2016.03.009]
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加味升阳益胃汤组方对荷瘤小鼠化疗后骨髓抑制及免疫功能的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年03期
页码:
291-294
栏目:
论著
出版日期:
2016-03-06

文章信息/Info

Title:
Effects of Jiawei Shengyang Yiwei decoction on bone marrow and immune function after chemotherapy in tumor bearing mice
作者:
张润莲; 岳斌; 李维; 王宝琴; 温丽英; 刘冬彦; 连平; 何晓华; 赵冬梅
075000 张家口，河北北方学院附属第一医院中医科（张润莲、岳斌、温丽英、连平、何晓华、赵冬梅）；河北省张家口市崇礼县中医院内科（李维）；河北省张家口市崇礼县妇幼保健院妇产科（王宝琴）；河北省张家口市沽源县医院内科（刘冬彦)
Author(s):
ZHANG Run lian;  YUE Bin;  LI Wei; et al.
The First Affiliated Hospital of Hebei North University， Zhangjiakou 075000， China
关键词:
加味升阳益胃汤组方; 荷瘤小鼠; 化疗; 骨髓抑制; 免疫功能
Keywords:
Jiawei Shengyang Yiwei decoction formula; Tumor bearing mice; Chemotherapy; Bone marrow suppression; Immune function influence
分类号:
R273
DOI:
10.3969/j.issn.1674-1749.2016.03.009
文献标志码:
A
摘要:
目的 重点探究加味升阳益胃汤组方对荷瘤小鼠化疗的骨髓抑制及免疫功能的影响。 方法 建立小鼠肉瘤 S180移植性肿瘤模型，并将小鼠分成五组，荷瘤细胞对照组腹腔注射生理盐水0.2 mL，环磷酰胺组注射环磷酰胺（cyclophosvnamide，CTX）20 mg/kg，三组治疗组分别给予注射同等剂量CTX化疗，同时给予不同剂量的加味升阳益胃汤组方，其中小剂量组每只中药灌胃0.1 mL，中剂量组每只中药灌胃0.2 mL，大剂量组每只中药灌胃0.3 mL，1 mL大约含有70 g生药量。结果 环磷酰胺组小鼠的白细胞、血红蛋白及血小板均降低，荷瘤对照组和环磷酰胺组对比差异有统计学意义（P＜0.05）。大剂量组、中剂量组、小剂量组的白细胞、血红蛋白及血小板均正常，大剂量组、中剂量组升高程度相对明显。三个剂量组和环磷酰胺组对比差异存在统计学意义（P＜0.05）。结论 加味升阳益胃汤组方能拮抗荷瘤小鼠化疗后引起的骨髓抑制及免疫功能的下降。
Abstract:
Objective To explore the effect of Jiawei Shengyang Yiwei decoction on on bone marrow and immune function after chemotherapy in tumor bearing mice. Methods Transplanted tumor in mice Sarcoma S180 model was established and mice were divided into five groups. Tumor cells control group was injected with 0.2 ml saline, CTX group was injected with cyclophosphamide, and three treatment groups were injected with CTX and were gavage with different dose of Jiawei Shengyang Yiwei decoction （0.1, 0.2, 0.3 ml). Results White cells, hemoglobin and blood platelet level decreased in mice in CTX group. There was significant difference between tumor cells control group and CTX group （P＜0.05＝. The white cells, hemoglobin, and blood platelet level of the three treatment group was normal, and much more obvious improvement appeared in high and medium dose group. There was significant difference between the three treatment groups and CTX group（P＜0.05）. Conclusion Jiawei Shengyang Yiwei decoction could be antagonistic to the bone marrow suppression and immune function decline caused by chemotherapy in tumor bearing mice.

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备注/Memo

备注/Memo:
作者简介：张润莲（1974- ），女，本科，副主任医师。研究方向：中医肿瘤临床和针灸教学工作。E-mail：109798530@qq.com
更新日期/Last Update: 2016-03-06