|本期目录/Table of Contents|

[1]王雪梅.参苓白术散对溃疡性结肠炎患者血浆MMP-2、MMP-9水平的影响[J].环球中医药,2016,9(04):398-401.[doi:10.3969/j.issn.1674-1749.2016.04.004]
　WANG Xue-mei.Effects of Shenling Baizhu Powder on serum MMP-2、 MMP-9 in patients with ulcerative colitis[J].,2016,9(04):398-401.[doi:10.3969/j.issn.1674-1749.2016.04.004]
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参苓白术散对溃疡性结肠炎患者血浆MMP-2、 MMP-9水平的影响()
     
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《环球中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
第9卷
期数:
2016年04期
页码:
398-401
栏目:
论著
出版日期:
2016-04-06

文章信息/Info

Title:
Effects of Shenling Baizhu Powder on serum MMP-2、 MMP-9 in patients with ulcerative colitis
作者:
王雪梅
065700 河北省廊坊市第四人民医院康复科
Author(s):
WANG Xue-mei
Department of Rehabilitation the Fourth People's Hospital of Langfang, Langfang 065700, China
关键词:
参苓白术散;  溃疡性结肠炎;  基质金属蛋白酶-2;  基质金属蛋白酶-9
Keywords:
Shenling Baizhu Powder;  Ulcerative colitis;  Matrix metalloproteinase-2;  Matrix metalloproteinase-9
分类号:
R285.6
DOI:
10.3969/j.issn.1674-1749.2016.04.004
文献标志码:
A
摘要:
目的 观察参苓白术散对溃疡性结肠炎(ulcerative colitis,UC)患者血浆基质金属蛋白酶(matrix metalloproteinase,MMP)-2、MMP-9表达水平的影响,探讨参苓白术散治疗UC的可能机制。方法 将80例UC患者随机分为对照组及试验组各40例,对照组予以口服美沙拉嗪治疗,试验组联合参苓白术散,1疗程8周。观察治疗前后症状并进行临床疗效评价,采用Mayo评分表对疾病活动度进行评价。检测外周静脉血浆MMP-2、MMP-9,计算乳果糖/甘露醇比值(LMR)。结果 试验组总有效率(92.50%)明显优于对照组总有效率(77.50%)(χ2 =6.877,P=0.032)。治疗后两组的Mayo评分均小于治疗前(t=12.584,t=14.641,P均<0.001),试验组治疗后的Mayo评分小于对照组(t=3.306,P=0.001)。血浆MMP-2、MMP-9水平较治疗前明显降低(P<0.001); 试验组低于对照组(t=3.039,P=0.003; t=4.669,P<0.001)。尿液LMR均小于治疗前(t=8.478,t=10.333,P均<0.001),试验组治疗后的尿液LMR小于对照组(t=2.834,P=0.006)。结论 参苓白术散联合美沙拉嗪治疗UC,可显著改善临床症状,降低Mayo得分; UC患者血浆MMP-2、MMP-9水平下调,肠黏膜通透性的改善,可能是参苓白术散治疗本病的机制之一。
Abstract:
Objective To explore the treatment mechanism of Shenling Baizhu Powder on patients with ulcerative colitis(UC)by observing the plasma matrix metalloproteinases(MMPs)level before and after the treatment. Methods 80 patients with UC were randomly divided into control group and experimental group, 40 patients in each group. Patients in the control group were given mesalazine and experimental group were given Shenling Baizhu Powder combined with mesalazine for 8 weeks. Before and after treatment, improvement of clinical symptoms was observed, and the disease activity was scored by Mayo. The blood samples of patients were collected and the plasma MMP-2、 MMP-9 were measured and the ratio of lactulose/mannitol was calculated. Result The total effective rate in the experimental group was 92.50%, superior to 77.50% in control group(χ2 =6.877,P=0.032). Mayo score after treatment in both groups was lower than that before treatment(t=12.584, t=14.641, P<0.001). Mayo score in the experimental group was lower than that in the control group(t=3.306,P=0.001)after treatment. The plasma levels of MMP-2、 MMP-9 were obviously decreased after treatment(P<0.001). The level was lower in the experimental group compared with the control group(t=3.039,P=0.003; t=4.669,P<0.001). The lactulose/mannitol ratio of both groups was decreased after treatment(t=8.478,t=10.333,P<0.001), and that in the experimental group was significantly lower than in the control group after treatment(t=2.834,P=0.006). Conclusion Shenling Baizhu Powder combined with mesalazine shows significant efficacy in improving the clinical symptoms and decreasing Mayo scores in patients with UC; Shenling Baizhu Powder can decrease the plasma levels of MMP-2,MMP-9, improve the permeability of intestinal mucosa, which may be one of the effective mechanisms in treating this disease.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介: 王雪梅(1977- ),女,本科,主治中医师。研究方向:中医内科。E-mail:fengxfxsof@sina.com
更新日期/Last Update: 2016-04-06